INT97237

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.72
First Reported 2001
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 33
Total Number 35
Disease Relevance 10.56
Pain Relevance 12.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (TRPV1) transport (TRPV1) plasma membrane (TRPV1)
lipid metabolic process (TRPV1)
Anatomy Link Frequency
keratinocytes 3
duct 2
trigeminal ganglion 2
blood 2
neurons 2
TRPV1 (Homo sapiens)
Pain Link Frequency Relevance Heat
TRP channel 17 100.00 Very High Very High Very High
vanilloid receptor subtype 1 8 100.00 Very High Very High Very High
ASIC 2 100.00 Very High Very High Very High
Eae 10 99.98 Very High Very High Very High
Pain 78 99.76 Very High Very High Very High
qutenza 431 99.68 Very High Very High Very High
nociceptor 34 99.66 Very High Very High Very High
Adelta 1 99.42 Very High Very High Very High
trigeminal ganglion 34 99.40 Very High Very High Very High
rheumatoid arthritis 5 99.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Injury 39 99.98 Very High Very High Very High
Acidosis 2 99.86 Very High Very High Very High
Ganglion Cysts 101 99.40 Very High Very High Very High
Glioma 8 99.08 Very High Very High Very High
Rheumatoid Arthritis 9 99.00 Very High Very High Very High
Neuroma 4 99.00 Very High Very High Very High
Liver Cancer 2 98.88 Very High Very High Very High
Osteoarthritis 6 97.96 Very High Very High Very High
Hyperalgesia 24 97.52 Very High Very High Very High
Renal Disease 9 97.04 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, the photoaged skin of elderly showed increased expression of TRPV1 mRNA and protein compared with that of the sun-protected skin of the same individuals.
Transcription (expression) of TRPV1 in skin
1) Confidence 0.72 Published 2009 Journal Exp. Dermatol. Section Abstract Doc Link 19161409 Disease Relevance 0.14 Pain Relevance 0.06
By RT-PCR analysis, the mRNA expression of TRPV1 was confirmed in human nasal mucosa.
Transcription (expression) of TRPV1 in nasal mucosa
2) Confidence 0.72 Published 2006 Journal Rhinology Section Abstract Doc Link 16792172 Disease Relevance 0.19 Pain Relevance 0.27
Expression of TRPV1 receptor mRNA was determined by quantitative RT-PCR.
Transcription (Expression) of TRPV1 receptor
3) Confidence 0.72 Published 2010 Journal Neuroimmunomodulation Section Body Doc Link 19923855 Disease Relevance 0.09 Pain Relevance 0
Using reverse-transcription polymerase chain reaction (RT-PCR) and quantitative real-time RT-PCR (qRT-PCR), TRPV1 and TRPV2 mRNA was detected in mRNA isolated from human whole peripheral blood.
Transcription (detected) of TRPV1 in blood
4) Confidence 0.71 Published 2007 Journal Mol. Immunol. Section Abstract Doc Link 16777226 Disease Relevance 0 Pain Relevance 0.09
In addition, the mRNA expression of TRPV1 was shown in PBMCs from healthy controls and from OA patients.
Transcription (expression) of TRPV1 associated with osteoarthritis
5) Confidence 0.70 Published 2007 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 17560936 Disease Relevance 0.90 Pain Relevance 0.60
VR1 mRNA and protein were expressed in human SMGs and a human salivary intercalated duct cell line.
Transcription (expressed) of VR1 in duct
6) Confidence 0.69 Published 2010 Journal J. Dent. Res. Section Abstract Doc Link 20371865 Disease Relevance 0 Pain Relevance 0.22
We show that RA highly up-regulated the total and cell surface TRPV1 protein expression but the TRPV1 mRNA level was unaffected.
Transcription (level) of TRPV1 associated with rheumatoid arthritis
7) Confidence 0.69 Published 2009 Journal Neurochem. Int. Section Abstract Doc Link 19651168 Disease Relevance 0.70 Pain Relevance 0.17
Unlike its mRNA, TRPV1 protein was detectable only in samples extracted from human trigeminal ganglion (TG).
Transcription (detectable) of TRPV1 protein in trigeminal ganglion associated with ganglion cysts and trigeminal ganglion
8) Confidence 0.69 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2566593 Disease Relevance 0.38 Pain Relevance 0.33
The level of the TRPV1 transcript in keratinocytes was orders of magnitudes lower than that in trigeminal ganglion.
Transcription (transcript) of TRPV1 in keratinocytes associated with ganglion cysts and trigeminal ganglion
9) Confidence 0.69 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2566593 Disease Relevance 0.36 Pain Relevance 0.18
While only slight changes were detected in the transcript level of TRPV1 after HaCaT cells exited the quiescent state and serum induced cell division occurred (Fig 3B), the level of TRPV1b transcript increased significantly and remained elevated throughout the experiment.
Transcription (transcript) of TRPV1b
10) Confidence 0.69 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2566593 Disease Relevance 0.06 Pain Relevance 0.21
Levels of TRPV1 transcript in keratinocytes, however, were orders of magnitudes lower than in human trigeminal ganglion neurons.
Transcription (transcript) of TRPV1 in neurons associated with ganglion cysts and trigeminal ganglion neurons
11) Confidence 0.69 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2566593 Disease Relevance 0.10 Pain Relevance 0.31
The expression levels of TRPV1 protein and mRNA in the cells of the person's buccal mucosa were less than half of those in a normal subject.
Transcription (levels) of TRPV1 protein
12) Confidence 0.69 Published 2007 Journal Neurosci. Lett. Section Abstract Doc Link 17110039 Disease Relevance 0.15 Pain Relevance 0.33
Using qRT-PCR, TRPV2 mRNA was highly expressed in human whole blood isolates (9.33+/-1.19 x 10(4)copies per 10(6)copies of the housekeeping gene GAPDH), whereas TRPV1 message was detected at approximately 150-fold lower levels (638+/-121 copies per 10(6)copies GAPDH).
Transcription (detected) of TRPV1 in blood
13) Confidence 0.69 Published 2007 Journal Mol. Immunol. Section Abstract Doc Link 16777226 Disease Relevance 0 Pain Relevance 0.08
These cells express the mRNA of TRPV1, TRPV2, TRPV3 and TRPV4 channels, but not those of TRPV5 and TRPV6.
Transcription (express) of TRPV1
14) Confidence 0.66 Published 2004 Journal Cell Calcium Section Abstract Doc Link 15126053 Disease Relevance 0.26 Pain Relevance 0.20
TRPV1 receptors are present in epithelial cells
Transcription (receptors) of TRPV1 in epithelial cells
15) Confidence 0.66 Published 2010 Journal Journal of Neurogastroenterology and Motility Section Body Doc Link PMC2978390 Disease Relevance 0 Pain Relevance 0.15
TRPV1 mRNA was detected in all human genitourinary tract tissues.
Transcription (detected) of TRPV1 mRNA
16) Confidence 0.65 Published 2004 Journal J. Urol. Section Body Doc Link 15311065 Disease Relevance 0 Pain Relevance 0
We defined the sites of mRNA and protein expression of TRPM8 and TRPV1 in the rat and human genitourinary tract.
Transcription (expression) of TRPV1
17) Confidence 0.65 Published 2004 Journal J. Urol. Section Abstract Doc Link 15311065 Disease Relevance 0.08 Pain Relevance 0.09
The dose of CAP concentrations causing non TRPV1 mediated cytotoxicity was ?
Transcription (causing) of TRPV1 associated with qutenza
18) Confidence 0.60 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2566593 Disease Relevance 0.06 Pain Relevance 0.29
We conclude that heat sensitization in deep and superficial capsaicin and capsaicin-insensitive C and Adelta nociceptors varies with the distribution of TRPV1 and TRPV2 proteins.
Transcription (distribution) of TRPV1 in nociceptors associated with qutenza, nociceptor and adelta
19) Confidence 0.58 Published 2007 Journal J. Neurophysiol. Section Abstract Doc Link 17287441 Disease Relevance 0 Pain Relevance 0.77
TRPV1 and TRPV2 mRNA expression in peripheral blood mononuclear cells (PBMC) was similar in controls and ESKD patients by quantitative real-time RT-PCR.
Transcription (expression) of TRPV1 in PBMC associated with renal disease
20) Confidence 0.58 Published 2009 Journal Biochim. Biophys. Acta Section Abstract Doc Link 19619644 Disease Relevance 0.83 Pain Relevance 0.70

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox