INT97254

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Context Info
Confidence 0.46
First Reported 2001
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 22
Total Number 22
Disease Relevance 7.36
Pain Relevance 4.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Gap43) plasma membrane (Gap43)
Anatomy Link Frequency
brain 2
subthalamic nucleus 1
striatum 1
dorsal horn 1
hippocampus 1
Gap43 (Mus musculus)
Pain Link Frequency Relevance Heat
substance P 20 100.00 Very High Very High Very High
Hippocampus 49 99.96 Very High Very High Very High
Calcitonin gene-related peptide 5 99.90 Very High Very High Very High
Substantia nigra 4 99.56 Very High Very High Very High
Sciatic nerve 205 99.48 Very High Very High Very High
Dorsal horn 4 98.52 Very High Very High Very High
Kinase C 11 98.36 Very High Very High Very High
abdominal pain 1 97.44 Very High Very High Very High
Inflammation 79 94.60 High High
Thalamus 27 92.88 High High
Disease Link Frequency Relevance Heat
Disease 227 99.84 Very High Very High Very High
Stroke 192 99.70 Very High Very High Very High
Frontotemporal Dementia 7 98.00 Very High Very High Very High
Abdominal Pain 1 97.44 Very High Very High Very High
Sciatic Neuropathy 2 97.40 Very High Very High Very High
Injury 176 96.68 Very High Very High Very High
INFLAMMATION 74 94.60 High High
Neuroma 9 94.00 High High
Targeted Disruption 49 91.68 High High
Neuropathic Pain 18 91.36 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
There was little increase of the positive area of GAP-43 stain of the control group.
Neg (little) Positive_regulation (increase) of GAP-43
1) Confidence 0.46 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2263011 Disease Relevance 0.22 Pain Relevance 0
Finally, in sections of injured sciatic nerves, we analyzed the expression of Cdc2 and GAP-43 proteins that are both up-regulated during peripheral regenerative processes.
Positive_regulation (up-regulated) of GAP-43 in sciatic nerves associated with sciatic nerve
2) Confidence 0.45 Published 2010 Journal Neuroscience Section Abstract Doc Link 20347016 Disease Relevance 0.70 Pain Relevance 0.66
DTI tractography showed fiber trajectories connecting the CL striatum to the stroke region, where increased GAP43 and FA were observed and fiber tracts from the CL striatum terminating in the IL hippocampus.
Positive_regulation (increased) of GAP43 in striatum associated with stroke and hippocampus
3) Confidence 0.41 Published 2007 Journal The Open Neuroimaging Journal Section Abstract Doc Link PMC2577937 Disease Relevance 0.58 Pain Relevance 0.17
Similarly, in the CL DG hippocampus, GAP 43 rOD was increased in the stroke compared to the sham group (Stroke 1.50 ±0.29 vs Sham 1.15 ± 0.05, p<0.01, Fig. 7B).


Positive_regulation (increased) of GAP 43 in hippocampus associated with stroke and hippocampus
4) Confidence 0.41 Published 2007 Journal The Open Neuroimaging Journal Section Body Doc Link PMC2577937 Disease Relevance 0.59 Pain Relevance 0.27
To identify the cells with strong SgIGSF immunoreactivity observed at 7 to 11 days after olfactory nerve transection, we performed double immunostaining in 11-day specimens for SgIGSF and PCNA, the marker of proliferating cells, or Gap43, the marker of immature olfactory cells (Fig. 5).
Positive_regulation (specimens) of Gap43 in olfactory
5) Confidence 0.40 Published 2007 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1874509 Disease Relevance 0 Pain Relevance 0
GAP 43 rOD was found to be increased in IL intact striatum/peri-infarct tissue (Fig. 7A, C and Fig. 5C and 6C) of the stroke brains compared to the shams; (Stroke 1.39 ± 0.33 vs Sham 1.06 ±0.05, p<0.05, Fig. 7A).
Positive_regulation (increased) of GAP 43 in brains associated with stroke
6) Confidence 0.36 Published 2007 Journal The Open Neuroimaging Journal Section Body Doc Link PMC2577937 Disease Relevance 0.57 Pain Relevance 0.19
While intense hybridization signals for MARCKS mRNA were observed in all of the other basal ganglia regions such as the globus pallidus, substantia innominata, subthalamic nucleus, and substantia nigra, intense signals for GAP-43 mRNA were restricted to the substantia innominata and substantia nigra pars compacta.
Positive_regulation (restricted) of GAP-43 mRNA in subthalamic nucleus associated with substantia nigra
7) Confidence 0.28 Published 2006 Journal J. Comp. Neurol. Section Abstract Doc Link 17029258 Disease Relevance 0 Pain Relevance 0.47
Furthermore, it has been shown that CSF GAP-43 and t-tau were increased in AD and correlated positively [123], suggesting both biomarkers are reflecting axonal and synaptic degeneration.

5.6.

Positive_regulation (increased) of GAP-43 associated with disease
8) Confidence 0.26 Published 2010 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC2915796 Disease Relevance 1.45 Pain Relevance 0
Calcitonin gene-related peptide and GAP43 immunoreactivity significantly increased and co-localized in cervicothoracic dorsal horn laminae I-III following C17.2 and C17.2/GDNF transplantation.
Positive_regulation (increased) of GAP43 in dorsal horn associated with dorsal horn and calcitonin gene-related peptide
9) Confidence 0.20 Published 2006 Journal Exp. Neurol. Section Abstract Doc Link 16839548 Disease Relevance 0.98 Pain Relevance 0.95
The stabilization of NF-L and increased GAP-43 did not correlate with the formation of the truncated fragments of Vimentin (Fig. 2C, graph).
Positive_regulation (increased) of GAP-43
10) Confidence 0.18 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2291557 Disease Relevance 0.22 Pain Relevance 0.06
The formation of the complex was corroborated with increased levels of GAP-43 specifically in the proximal fragment of the injured nerve still connected to nerve cell bodies (Fig. 3B).
Positive_regulation (increased) of GAP-43 in proximal
11) Confidence 0.18 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2291557 Disease Relevance 0 Pain Relevance 0.12
The stabilization of NF-L and increased GAP-43 did not correlate with the formation of the truncated fragments of Vimentin (Fig. 2C, graph).
Positive_regulation (stabilization) of GAP-43
12) Confidence 0.18 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2291557 Disease Relevance 0.22 Pain Relevance 0.06
BACKGROUND/PURPOSE: Increased neuroproliferation in the appendix associated with an increase in substance P (SP), vasoactive intestinal polypeptide (VIP), and growth-associated protein-43 (GAP-43) has been documented in appendices of adults with acute right lower quadrant (RLQ) abdominal pain and absence of gross or histologic signs of appendiceal inflammation.
Positive_regulation (increase) of GAP-43 in appendices associated with abdominal pain, inflammation and substance p
13) Confidence 0.15 Published 2001 Journal J. Pediatr. Surg. Section Abstract Doc Link 11479861 Disease Relevance 0.19 Pain Relevance 0.31
This was demonstrated by a reduction in levels of Vimentin and GAP-43, a marker for axonal regeneration, as well as NF-H, a late marker for axonal maturation in Ndel1 siRNA treated nerves (Fig. 6).
Positive_regulation (levels) of GAP-43 in nerves
14) Confidence 0.13 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2291557 Disease Relevance 0.09 Pain Relevance 0
The degree of augmentation in Ndel1 levels also correlated with higher levels of GAP-43, a neuronal marker for axonal regeneration, and with stabilization of NF-L, a marker for advanced regeneration and maturation (Fig. 2C).
Positive_regulation (levels) of GAP-43 in neuronal
15) Confidence 0.13 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2291557 Disease Relevance 0.22 Pain Relevance 0.07
Each gene (Ndel1, Vimentin, GAP-43, and GAPDH) was amplified for 33cycles. 10 µl aliquots of PCR products were electrophoresed on a 1.5 % agarose gel in Tri-acetate-EDTA (TAE) buffer and visualized by staining with etidium bromide (EtBr).
Positive_regulation (amplified) of GAP-43
16) Confidence 0.12 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2291557 Disease Relevance 0 Pain Relevance 0.04
Beside its function as an energy store in the form of triacylglycerides, oleate is part of biological cell membranes and is believed to be involved in protein kinase C (PKC) dependent second messenger cascades, thereby influencing, for example, the activation of regeneration-associated genes such as GAP-43 [50,51].
Positive_regulation (activation) of GAP-43 associated with kinase c
17) Confidence 0.12 Published 2003 Journal BMC Neurosci Section Body Doc Link PMC161801 Disease Relevance 0 Pain Relevance 0.05
S increased expression levels of the growth-associated protein 43 (GAP-43) as a marker for axonal growth in wild-type but not in P2Y2 ?
Positive_regulation (increased) of growth-associated protein 43
18) Confidence 0.11 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072925 Disease Relevance 0.40 Pain Relevance 0.14
While intense hybridization signals for MARCKS mRNA were observed in all of the other basal ganglia regions such as the globus pallidus, substantia innominata, subthalamic nucleus, and substantia nigra, intense signals for GAP-43 mRNA were restricted to the substantia innominata and substantia nigra pars compacta.
Positive_regulation (restricted) of GAP-43 mRNA in substantia nigra associated with substantia nigra
19) Confidence 0.09 Published 2006 Journal J. Comp. Neurol. Section Abstract Doc Link 17029258 Disease Relevance 0 Pain Relevance 0.47
GAP43 mRNA levels, which decrease with age in wild type mice, at the opposite increased in MPSIIIB mice, switching from abnormally low levels in young mice to abnormally high levels in aged mice, as previously described [30].
Positive_regulation (increased) of GAP43 mRNA
20) Confidence 0.08 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2396504 Disease Relevance 0.57 Pain Relevance 0.14

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