INT97264

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Context Info
Confidence 0.36
First Reported 2001
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 9
Total Number 10
Disease Relevance 4.27
Pain Relevance 4.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cellular_component (Mc1r)
Anatomy Link Frequency
hair 3
skin 2
Mc1r (Rattus norvegicus)
Pain Link Frequency Relevance Heat
melanocortin 1 receptor 71 100.00 Very High Very High Very High
agonist 1 99.24 Very High Very High Very High
antagonist 1 97.52 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hypopigmentation 7 100.00 Very High Very High Very High
Skin Cancer 59 99.92 Very High Very High Very High
Wrinkles 7 98.04 Very High Very High Very High
Cutaneous Melanoma 1 91.36 High High
Cancer 2 82.72 Quite High
Erythema 9 80.72 Quite High
Syndrome 1 75.00 Quite High
Stress 1 70.00 Quite High
Sunburn 1 67.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The most important regulators are the melanocortin 1 receptor and its ligands, the melanocortin agonists and the agouti-signalling protein antagonist.
melanocortin 1 receptor Binding (ligands) of associated with melanocortin 1 receptor, antagonist and agonist
1) Confidence 0.36 Published 2008 Journal Trends Ecol. Evol. (Amst.) Section Abstract Doc Link 18644658 Disease Relevance 0.14 Pain Relevance 0.20
Melanocortin 1 receptor gene variants are also associated with other risk factors for melanoma such as fair skin and red hair.
Melanocortin 1 receptor Binding (associated) of in hair associated with melanocortin 1 receptor and skin cancer
2) Confidence 0.33 Published 2001 Journal J. Invest. Dermatol. Section Abstract Doc Link 11511307 Disease Relevance 0.56 Pain Relevance 0.50
To analyze the association between melanocortin 1 receptor gene variants and skin type or hair color we also made use of 453 patients with nonmelanoma skin cancer.
melanocortin 1 receptor Spec (analyze) Binding (association) of in hair associated with melanocortin 1 receptor and skin cancer
3) Confidence 0.25 Published 2001 Journal J. Invest. Dermatol. Section Abstract Doc Link 11511307 Disease Relevance 0.68 Pain Relevance 0.73
Phototesting was performed in 20 redheads and 20 nonredheaded subjects, the majority of whom were also screened for the presence of melanocortin 1 receptor variants.
melanocortin 1 receptor Binding (presence) of associated with melanocortin 1 receptor
4) Confidence 0.25 Published 2001 Journal J. Invest. Dermatol. Section Abstract Doc Link 11710950 Disease Relevance 0.36 Pain Relevance 0.45
Melanocortin 1 receptor (MC1R) gene variants are associated with an increased risk for cutaneous melanoma which is largely independent of skin type and hair color.
Melanocortin 1 receptor Binding (associated) of in hair associated with melanocortin 1 receptor and skin cancer
5) Confidence 0.24 Published 2001 Journal J. Invest. Dermatol. Section Title Doc Link 11511307 Disease Relevance 0.63 Pain Relevance 0.69
Melanocortin 1 receptor (MC1R) gene variants are associated with red hair and fair skin color.
Melanocortin 1 receptor Binding (associated) of in skin associated with melanocortin 1 receptor
6) Confidence 0.15 Published 2006 Journal Int. J. Cancer Section Abstract Doc Link 16721784 Disease Relevance 0.62 Pain Relevance 0.43
Variation at the melanocortin 1 receptor (MC1R) is very common in most non-African world populations.
melanocortin 1 receptor Binding (Variation) of associated with melanocortin 1 receptor
7) Confidence 0.13 Published 2006 Journal J. Invest. Dermatol. Section Abstract Doc Link 16845407 Disease Relevance 0.27 Pain Relevance 0.28
We have examined the frequency of SNP polymorphisms within the melanocortin-1 receptor (MC1R) and agouti signaling protein (ASIP) genes in 114 Korean vitiligo patients and 111 normal controls to assess the association of these loci with vitiligo risk.
melanocortin-1 receptor Binding (association) of associated with melanocortin 1 receptor and hypopigmentation
8) Confidence 0.08 Published 2003 Journal Pigment Cell Res. Section Abstract Doc Link 12859622 Disease Relevance 0.34 Pain Relevance 0.44
The objective of this study was to assess the association between melanocortin-1 receptor (MC1R) variants and the severity of facial skin photoaging.
melanocortin-1 receptor Binding (association) of in skin associated with melanocortin 1 receptor and wrinkles
9) Confidence 0.08 Published 2010 Journal J. Invest. Dermatol. Section Abstract Doc Link 19924138 Disease Relevance 0.40 Pain Relevance 0.34
Characterization of melanocortin-1 receptor gene variants in uveal melanoma patients.
melanocortin-1 receptor Binding (Characterization) of associated with melanocortin 1 receptor and skin cancer
10) Confidence 0.03 Published 2001 Journal Invest. Ophthalmol. Vis. Sci. Section Title Doc Link 11481256 Disease Relevance 0.28 Pain Relevance 0.47

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