INT97272

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Context Info
Confidence 0.34
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.30
Pain Relevance 0.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Chrm1) plasma membrane (Chrm1) signal transducer activity (Chrm1)
Chrm1 (Mus musculus)
Pain Link Frequency Relevance Heat
analgesia 1 99.40 Very High Very High Very High
antinociception 3 95.80 Very High Very High Very High
antagonist 15 92.72 High High
depression 6 85.80 High High
Hippocampus 20 82.96 Quite High
long-term potentiation 126 74.16 Quite High
Pyramidal cell 30 66.44 Quite High
potassium channel 12 62.88 Quite High
Action potential 10 52.56 Quite High
agonist 44 51.56 Quite High
Disease Link Frequency Relevance Heat
Depression 6 85.80 High High
Ganglion Cysts 2 56.16 Quite High
Cognitive Disorder 14 5.00 Very Low Very Low Very Low
Disease 6 5.00 Very Low Very Low Very Low
Camurati-engelmann Disease 2 5.00 Very Low Very Low Very Low
Targeted Disruption 2 5.00 Very Low Very Low Very Low
Schizophrenia 2 5.00 Very Low Very Low Very Low
Spontaneous Rupture 2 5.00 Very Low Very Low Very Low
Disseminated Intravascular Coagulation 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This indicates that the depolarizing action of acetylcholine is due to M1 receptor activation, but the effects on synaptic transmission are due to activation of nicotinic receptors or mAChRs other than M1.
Positive_regulation (due) of Positive_regulation (activation) of M1 receptor
1) Confidence 0.34 Published 2010 Journal Neuron Section Body Doc Link PMC3003154 Disease Relevance 0.24 Pain Relevance 0.34
While this may indeed be the case, our data indicate that KCNQ channels do not mediate the facilitation of NMDAR function induced by M1 receptor activation since blockade of KCNQ channels with XE-991 did not prevent the actions of M1 receptor activation on NMDAR function (FigureĀ 6).
Positive_regulation (induced) of Positive_regulation (activation) of M1 receptor
2) Confidence 0.34 Published 2010 Journal Neuron Section Body Doc Link PMC3003154 Disease Relevance 0.06 Pain Relevance 0.10
M1 receptor activation is a requirement for arecoline analgesia.
Positive_regulation (requirement) of Positive_regulation (activation) of M1 receptor associated with analgesia
3) Confidence 0.23 Published 2001 Journal Farmaco Section Title Doc Link 11482763 Disease Relevance 0 Pain Relevance 0.41

General Comments

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