INT97280

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Context Info
Confidence 0.77
First Reported 2001
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 11
Total Number 19
Disease Relevance 16.17
Pain Relevance 1.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

kinase activity (Tk1) cytoplasm (Tk1)
Anatomy Link Frequency
TK-1 2
B16-F10 1
glands 1
Tk1 (Mus musculus)
Pain Link Frequency Relevance Heat
imagery 293 99.92 Very High Very High Very High
positron emission tomography 400 99.00 Very High Very High Very High
Pain 6 68.08 Quite High
Versed 9 47.32 Quite Low
anesthesia 15 43.84 Quite Low
Inflammatory response 9 38.36 Quite Low
isoflurane 13 5.00 Very Low Very Low Very Low
Inflammation 12 5.00 Very Low Very Low Very Low
alcohol 5 5.00 Very Low Very Low Very Low
ketamine 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cold Sores 184 100.00 Very High Very High Very High
Herpes Simplex Virus 22 100.00 Very High Very High Very High
Cancer 1271 99.88 Very High Very High Very High
Skin Cancer 177 99.84 Very High Very High Very High
Toxicity 7 99.44 Very High Very High Very High
Adenoma 4 97.52 Very High Very High Very High
Viral Infection 5 96.68 Very High Very High Very High
Infection 65 96.00 Very High Very High Very High
Necrosis 9 93.84 High High
Pituitary Cancer 27 92.04 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We found a significant decrease in 18F-FLT uptake as early as 2 and 6 hours after treatment initiation; however, despite a significantly lower 18F-FLT uptake at 6 hours, a decrease in TK1 gene expression was first evident on Day 1 after treatment initiation.
Gene_expression (expression) of TK1 gene
1) Confidence 0.77 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2945761 Disease Relevance 0 Pain Relevance 0.03
Gene expression levels of Ki67 and TK1 are shown in figure 6.
Gene_expression (expression) of TK1
2) Confidence 0.77 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2945761 Disease Relevance 0 Pain Relevance 0
Expression of Ki67 and TK1 was analyzed in vitro in a parallel group of mice, which were treated with either Top216 or vehicle and biopsied before and at 6, 30 (Day 1) and 126 (Day 5) hours after initiation of treatment.
Spec (analyzed) Gene_expression (Expression) of TK1
3) Confidence 0.77 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2945761 Disease Relevance 0.52 Pain Relevance 0
Uptake of 18F-FLT was compared with uptake of 18F-FDG and Ki67 and TK1 gene expression.


Gene_expression (expression) of TK1 gene
4) Confidence 0.77 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2945761 Disease Relevance 0.71 Pain Relevance 0.09
Expression of Ki67 and TK1
Gene_expression (Expression) of TK1
5) Confidence 0.77 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2945761 Disease Relevance 0 Pain Relevance 0
In the treatment group expression of TK1 was significantly decreased at Day 1 (?
Gene_expression (expression) of TK1
6) Confidence 0.67 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2945761 Disease Relevance 0.05 Pain Relevance 0.04
Moreover, by RT-PCR and ChIPs on tissues, expression of E2F-target genes, such as CDC1 and TK1, was shown to be enhanced, and E2F1 to be more acetylated in adenomas compared to normal glands (unpublished data).
Gene_expression (expression) of TK1 in glands associated with adenoma
7) Confidence 0.64 Published 2006 Journal Cell Div Section Body Doc Link PMC1563461 Disease Relevance 0.90 Pain Relevance 0
At Day 5 expression of TK1 was increased (30%, P?
Gene_expression (expression) of TK1
8) Confidence 0.60 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2945761 Disease Relevance 0.06 Pain Relevance 0.04
Gene expression levels of Ki67 and TK1 are shown in figure 6.
Gene_expression (levels) of TK1
9) Confidence 0.60 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2945761 Disease Relevance 0 Pain Relevance 0
TK1 activity is tightly cell cycle regulated and is mainly expressed during the S-phase of the cell cycle; consequently, it is assumed to reflect the amount of proliferating cells [4], [5]. 18F-FLT uptake is positively correlated with cell growth and TK1 activity [5]–[7].
Gene_expression (expressed) of TK1
10) Confidence 0.60 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2945761 Disease Relevance 0.61 Pain Relevance 0.17
The expression of HSV1-tk can be imaged and monitored using specific radiolabeled substrates that are selectively phosphorylated by HSV1-tk and trapped within transfected cells.
Gene_expression (expression) of HSV1-tk associated with cold sores
11) Confidence 0.59 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2651472 Disease Relevance 1.72 Pain Relevance 0.14
-galactosidase was correlated with HSV1-tk expression in melanoma cells (Figure 2C).
Gene_expression (expression) of HSV1-tk associated with cold sores and skin cancer
12) Confidence 0.59 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2651472 Disease Relevance 1.58 Pain Relevance 0.05
Three radiotracers that are widely used by many investigators for imaging of HSV1-tk gene expression are [18F]FEAU, [124I]-2?
Gene_expression (expression) of HSV1-tk associated with cold sores and imagery
13) Confidence 0.59 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2651472 Disease Relevance 1.78 Pain Relevance 0.09
HSV1-tk–expressing bacteria have recently been shown to localize in various tumors, including B16-F10 murine melanoma cells, and primary tumors were successfully imaged with [124I]FIAU or [18F]FEAU [41], [42].
Gene_expression (expressing) of HSV1-tk in B16-F10 associated with cold sores, cancer and skin cancer
14) Confidence 0.51 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2651472 Disease Relevance 1.65 Pain Relevance 0.09
Phosphorylated [18F]FEAU, is trapped inside HSV1-tk expressing cancer cells; it accumulates in proportion to the level of HSV1-tk expression and can be imaged using PET (Figure 1A).
Gene_expression (expression) of HSV1-tk associated with cold sores, cancer and positron emission tomography
15) Confidence 0.46 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2651472 Disease Relevance 1.05 Pain Relevance 0.29
All tumors demonstrated expression of glucose transporter-1, thymidine kinase-1, and hexokinase II.
Gene_expression (expression) of thymidine kinase-1 associated with cancer
16) Confidence 0.38 Published 2007 Journal Mol Imaging Biol Section Abstract Doc Link PMC2040178 Disease Relevance 0.83 Pain Relevance 0.16
Expression of VEGF, HK I, HK III, and TK-1 expression was similar for control tumors and irradiated tumors.
Gene_expression (expression) of TK-1 in TK-1 associated with cancer
17) Confidence 0.38 Published 2007 Journal Mol Imaging Biol Section Body Doc Link PMC2040178 Disease Relevance 1.67 Pain Relevance 0.04
Expression of VEGF, HK I, HK III, and TK-1 expression was similar for control tumors and irradiated tumors.
Gene_expression (Expression) of TK-1 in TK-1 associated with cancer
18) Confidence 0.38 Published 2007 Journal Mol Imaging Biol Section Body Doc Link PMC2040178 Disease Relevance 1.63 Pain Relevance 0.04
Toxicity assessment of intratumoral injection of the herpes simplex type I thymidine kinase gene delivered by retrovirus in patients with refractory cancer.
Gene_expression (injection) of herpes simplex type I thymidine kinase gene associated with toxicity, cancer and herpes simplex virus
19) Confidence 0.10 Published 2001 Journal Mol. Ther. Section Title Doc Link 11482988 Disease Relevance 1.40 Pain Relevance 0.07

General Comments

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