INT97307

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.06
First Reported 2001
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 12
Total Number 13
Disease Relevance 5.67
Pain Relevance 2.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (NXT1) intracellular (NXT1) cytoplasm (NXT1)
Anatomy Link Frequency
joint 1
cortical bone 1
face 1
parathyroid 1
Knee 1
NXT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
imagery 90 100.00 Very High Very High Very High
Pain score 1 99.68 Very High Very High Very High
Osteoarthritis 367 98.68 Very High Very High Very High
Analgesic 3 98.32 Very High Very High Very High
backache 8 97.92 Very High Very High Very High
Restless leg syndrome 4 90.88 High High
Pain 20 87.84 High High
dexamethasone 7 55.40 Quite High
Opioid 9 50.00 Quite Low
Arthritis 22 26.92 Quite Low
Disease Link Frequency Relevance Heat
Pain 16 99.68 Very High Very High Very High
Obesity 72 99.16 Very High Very High Very High
Knee Osteoarthritis 240 98.68 Very High Very High Very High
Osteoarthritis 127 98.52 Very High Very High Very High
Low Back Pain 8 97.92 Very High Very High Very High
Multiple Myeloma 29 95.80 Very High Very High Very High
Anaemia 1 95.48 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 3 95.04 Very High Very High Very High
Pathologic Constriction 2 92.44 High High
Cancer 7 91.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Effect of complexation of NTX with TA?
NTX Binding (complexation) of
1) Confidence 0.06 Published 2010 Journal Drug Des Devel Ther Section Body Doc Link PMC2948935 Disease Relevance 0 Pain Relevance 0
CD forms noncovalent and poorly water soluble complexes with NTX and reduced drug solubility in aqueous medium and total concentration of diffusible species, resulting in a retarded release.
NTX Binding (complexes) of
2) Confidence 0.06 Published 2010 Journal Drug Des Devel Ther Section Body Doc Link PMC2948935 Disease Relevance 0 Pain Relevance 0
BMD: bone mineral density; BMI: body mass index; BML: bone marrow lesion; BOKS: Boston Osteoarthritis Knee Study; BSAP: bone-specific alkaline phosphatase; Cr: creatinine; MRI: magnetic resonance imaging; NTx: type I collagen N-telopeptide; OA: osteoarthritis.


NTx Binding (imaging) of in Knee associated with obesity, imagery and osteoarthritis
3) Confidence 0.05 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575616 Disease Relevance 0.86 Pain Relevance 0.43
CONCLUSIONS: This preliminary study shows that the association of NTX further amplifies the lymphocytosis obtained by IL-2 plus MLT.
NTX Binding (association) of
4) Confidence 0.05 Published 2002 Journal Neuro Endocrinol. Lett. Section Body Doc Link 12195238 Disease Relevance 0.06 Pain Relevance 0
Serum NTx was weakly associated with BMLs presence in both study samples.
NTx Binding (associated) of
5) Confidence 0.05 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575616 Disease Relevance 0.82 Pain Relevance 0.39
Serum NTx was weakly associated with the presence of BMLs in both study samples.
NTx Binding (associated) of
6) Confidence 0.05 Published 2008 Journal Arthritis Res Ther Section Abstract Doc Link PMC2575616 Disease Relevance 0.32 Pain Relevance 0.04
Serum NTx appears to be consistently weakly associated with the presence of BMLs.
NTx Binding (associated) of
7) Confidence 0.05 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575616 Disease Relevance 0.25 Pain Relevance 0.04
Ln-NTx exhibited a significant association with BMLs, with the odds of a BML being present increasing by 1.4-fold (95% confidence interval = 1.0-fold to 2.0-fold) per 1 standard deviation increase in the LnNTx, and with a small partial R2 of 3.05.
NTx Binding (association) of
8) Confidence 0.05 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575616 Disease Relevance 0.23 Pain Relevance 0.09
The level of urinary cross-linked N-terminal telopeptides of type I collagen (NTx) measured by an enzyme-linked immunosorbent assay, back pain evaluated with the face scale score, and the ADL score (disability) determined with a questionnaire were assessed before and 3 and 6 months after the start of treatment.
NTx Spec (determined) Binding (cross-linked) of in face associated with backache
9) Confidence 0.04 Published 2003 Journal Keio J Med Section Abstract Doc Link 14748475 Disease Relevance 0.51 Pain Relevance 0.35
The bone turnover markers bALP, PINP, Dickkopf 1 (DKK-1) and N-terminal crosslinked telopeptide of type I collagen (NTX-I) were measured together with parathyroid hormone (PTH), calcium and albumin during the study period.
NTX-I Binding (crosslinked) of in parathyroid
10) Confidence 0.02 Published 2010 Journal European Journal of Haematology Section Body Doc Link PMC2970902 Disease Relevance 0.17 Pain Relevance 0.03
A RCT (n = 231, study period 1 year) by Spector, et al.8 showed that risedronate (15 mg/day) reduced urinary levels of C-terminal crosslinking telopeptide of type II collagen (CTX-II) (Fig. 1) and N-terminal crosslinking telopeptide of type I collagen (NTX-I) in a dose-dependent manner, improved PGA scores but not WOMAC scores, reduced the proportion of patients who used walking aids, but did not attenuate joint space narrowing.
NTX-I Binding (crosslinking) of in joint associated with acquired immune deficiency syndrome or hiv infection
11) Confidence 0.01 Published 2010 Journal Yonsei Medical Journal Section Body Doc Link PMC2824859 Disease Relevance 0.81 Pain Relevance 0.37
Clinical symptoms, levels of urinary cross-linked N-telopeptides of type I collagen (NTx), and metacarpal cortical bone mineral density (BMD) were assessed before and just after the 6 months of treatment.
NTx Binding (cross-linked) of in cortical bone
12) Confidence 0.01 Published 2001 Journal J Orthop Sci Section Abstract Doc Link 11484118 Disease Relevance 0.70 Pain Relevance 0.40
Reduced Cox multivariate models identified five significant prognostic factors for first SRE (weight, race, high N-terminal cross-linked telopeptide of type I collagen (NTX), high pain score, and need for narcotic analgesics) and seven for survival (age, SRE history, myeloma subtype, anemia, high lactate dehydrogenase, high NTX, and low albumin levels).
NTX Binding (cross-linked) of associated with anaemia, pain score and analgesic
13) Confidence 0.01 Published 2010 Journal Leukemia Section Abstract Doc Link 20376081 Disease Relevance 0.97 Pain Relevance 0.20

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox