INT97315

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Context Info
Confidence 0.58
First Reported 2001
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 1.60
Pain Relevance 0.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (LGALS3) extracellular region (LGALS3) mRNA processing (LGALS3)
proteinaceous extracellular matrix (LGALS3) plasma membrane (LGALS3) nucleus (LGALS3)
Anatomy Link Frequency
smooth muscle 1
LGALS3 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 45 99.64 Very High Very High Very High
Osteoarthritis 90 91.08 High High
Dysuria 1 69.00 Quite High
Inflammation 33 48.68 Quite Low
cytokine 6 5.00 Very Low Very Low Very Low
isoflurane 3 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoarthritis 99 91.08 High High
Osteoporosis 18 90.28 High High
Malignant Fibrous Histiocytoma 1 86.56 High High
Targeted Disruption 3 85.92 High High
Sarcoma 1 84.80 Quite High
Squamous Cell Carcinoma 1 84.24 Quite High
Carcinosarcoma 3 82.52 Quite High
Diverticulum 4 75.96 Quite High
Hematuria 1 68.52 Quite High
Pressure And Volume Under Development 33 66.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Alkaline phosphatase, which is upregulated by vitamin D3, tended to be increased with gal-3 at 1 ?
Positive_regulation (increased) of gal-3
1) Confidence 0.58 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860078 Disease Relevance 0.27 Pain Relevance 0.16
We show that ADAMTS-5 was more sensitive than MMP-3 to gal-3, since its expression was stimulated with very low concentrations of gal-3, unlike MMP-3, which required higher concentrations for stimulation.
Positive_regulation (concentrations) of gal-3 associated with metalloproteinase
2) Confidence 0.48 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860078 Disease Relevance 0.26 Pain Relevance 0.19
Alkaline phosphatase expression was increased with gal-3 at 1 ?
Positive_regulation (increased) of gal-3
3) Confidence 0.42 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860078 Disease Relevance 0.37 Pain Relevance 0.24
Both components were reactive for galectin-3, whereas S100, desmin and smooth muscle actin were negative.
Positive_regulation (reactive) of galectin-3 in smooth muscle
4) Confidence 0.22 Published 2001 Journal J. Exp. Clin. Cancer Res. Section Abstract Doc Link 11484992 Disease Relevance 0.71 Pain Relevance 0.07

General Comments

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