INT97318

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Context Info
Confidence 0.67
First Reported 2001
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 11
Total Number 11
Disease Relevance 5.07
Pain Relevance 1.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (SPARC) extracellular space (SPARC) extracellular region (SPARC)
proteinaceous extracellular matrix (SPARC) nucleus (SPARC) intracellular (SPARC)
Anatomy Link Frequency
lung 2
osteoblast 1
stem cells 1
SPARC (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 12 99.62 Very High Very High Very High
metalloproteinase 10 96.48 Very High Very High Very High
Etanercept 7 86.48 High High
COX2 1 82.52 Quite High
dexamethasone 7 79.32 Quite High
cytokine 13 78.12 Quite High
pulpitis 1 76.04 Quite High
Inflammation 38 73.72 Quite High
Infliximab 5 66.76 Quite High
antiepileptic Drug 1 50.00 Quite Low
Disease Link Frequency Relevance Heat
Osteoporosis 107 100.00 Very High Very High Very High
Dermatomyositis 16 99.80 Very High Very High Very High
INFLAMMATION 44 99.52 Very High Very High Very High
Lung Cancer 5 99.24 Very High Very High Very High
Colon Cancer 15 98.64 Very High Very High Very High
Natriuresis 1 97.40 Very High Very High Very High
Hypercalcemia 20 94.20 High High
Cancer 115 92.80 High High
Stress 18 89.28 High High
Calcification 49 89.04 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, we demonstrated that upregulation of SPARC expression by NS398 in human lung cancer cells is mediated by promoter demethylation and associated with a decrease in DNA methyltransferase (DNMT) expression.
Gene_expression (expression) of SPARC in lung associated with lung cancer
1) Confidence 0.67 Published 2008 Journal Exp. Biol. Med. (Maywood) Section Abstract Doc Link 18367635 Disease Relevance 0.49 Pain Relevance 0.50
The nonsteroidal anti-inflammatory drug NS398 reactivates SPARC expression via promoter demethylation to attenuate invasiveness of lung cancer cells.
Gene_expression (expression) of SPARC in lung associated with lung cancer, inflammation and cinod
2) Confidence 0.67 Published 2008 Journal Exp. Biol. Med. (Maywood) Section Title Doc Link 18367635 Disease Relevance 0.53 Pain Relevance 0.55
Strong immunostaining of osteopontin appeared in the peripheral area of the stones, whereas osteonectin and osteocalcin were not detected.
Neg (not) Gene_expression (detected) of osteonectin
3) Confidence 0.61 Published 2001 Journal J Endod Section Abstract Doc Link 11485265 Disease Relevance 0.42 Pain Relevance 0.08
The same authors also reported that calcifications from JDM patients contained more osteonectin than is usually found in human bone.
Gene_expression (contained) of osteonectin associated with dermatomyositis
4) Confidence 0.29 Published 2010 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC2831027 Disease Relevance 0.58 Pain Relevance 0.39
Six proteins (ANXA3, BMP4, LCN2, SPARC, MMP7, and MMP11) were found to be over-expressed in colorectal tumoral tissues by using immunoblotting and tissue microarray analysis.
Gene_expression (expressed) of SPARC
5) Confidence 0.26 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1852117 Disease Relevance 0.95 Pain Relevance 0
Transcription of marker genes changed from chondrogenic to also include osteogenic, as mRNA of osteocalcin, runx2, osteonectin and col1a were detected.
Gene_expression (detected) of osteonectin
6) Confidence 0.16 Published 2010 Journal BMC Physiol Section Body Doc Link PMC2909226 Disease Relevance 0.17 Pain Relevance 0
Some of the key transcription factors in bone metabolism include runx2 and osterix [18], involved in the differentiation of mesenchymal stem cells (MSC) into osteoblasts that express bone matrix (col1a) and matrix mineralizing (osteocalcin and osteonectin) genes.
Gene_expression (express) of osteonectin in stem cells
7) Confidence 0.16 Published 2010 Journal BMC Physiol Section Body Doc Link PMC2909226 Disease Relevance 0.24 Pain Relevance 0.03
The average percent of cells expressing the preosteoblast integrins osteopontin (OP) and osteonectin (ON) were measured by FACScan analysis by flow cytometry.


Gene_expression (expressing) of osteonectin
8) Confidence 0.13 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2958849 Disease Relevance 0.08 Pain Relevance 0.04
We performed Real-time RT-PCR assays to detect the expression levels of osteoblast specific marker genes MSX2 (homeobox gene MSX2), VDR (vitamin D receptor), COL1A1 (collagen 1A1), ALPL (alkaline phosphatase), SPARC (osteonectin), SPP1 (osteopontin) and BGLAP (osteocalcin) to prove the osteoblast phenotype.
Gene_expression (expression) of osteonectin in osteoblast associated with osteoporosis
9) Confidence 0.13 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1829400 Disease Relevance 0.55 Pain Relevance 0
Levels of peroxisome proliferator-activated receptor gamma co-activator 1alpha mRNA were increased, while the expression of the genes encoding leptin, osteonectin, phosphodiesterase 3B, hormone-sensitive lipase, receptor A for natriuretic peptide, fatty acid translocase, lipoprotein lipase, uncoupling protein 2 and peroxisome proliferator-activated receptor gamma was decreased [39].
Gene_expression (expression) of osteonectin associated with natriuresis
10) Confidence 0.11 Published 2005 Journal J Int Soc Sports Nutr Section Body Doc Link PMC2129146 Disease Relevance 0.56 Pain Relevance 0
The organic matrix is comprised predominantly of type I collagen (90–95%) with contributions from various other proteins including osteocalcin, osteonectin, osteopontin and thrombospondin [10].
Gene_expression (comprised) of osteonectin
11) Confidence 0.08 Published 2006 Journal Nutr Metab (Lond) Section Body Doc Link PMC1586194 Disease Relevance 0.51 Pain Relevance 0

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