INT9732

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Context Info
Confidence 0.58
First Reported 1992
Last Reported 2010
Negated 3
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 6.93
Pain Relevance 0.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (COL2A1) extracellular region (COL2A1) cytoplasm (COL2A1)
Anatomy Link Frequency
chondrocyte 1
COL2A1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 2 93.44 High High
aspirin 3 90.08 High High
Osteoarthritis 29 78.24 Quite High
Chronic pancreatitis 9 76.16 Quite High
Inflammation 37 53.52 Quite High
cytokine 3 48.72 Quite Low
alcohol 1 46.32 Quite Low
fibrosis 5 42.40 Quite Low
Pain 7 5.00 Very Low Very Low Very Low
Earache 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Otitis Media 405 100.00 Very High Very High Very High
Recurrence 42 99.28 Very High Very High Very High
Viral Infection 18 98.60 Very High Very High Very High
Congenital Anomalies 2 96.72 Very High Very High Very High
Deafness 12 94.52 High High
Targeted Disruption 2 92.20 High High
Lower Respiratory Tract Infection 6 91.84 High High
Stress 7 91.68 High High
Mrsa Infection 15 90.12 High High
Asthma 3 89.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, NFAT5 seems to be crucially involved in this differential regulation upon hypertonic challenge: it positively regulates collagen type II, while suppressing collagen type I (Figure 5b).
Regulation (regulates) of collagen type II
1) Confidence 0.58 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911888 Disease Relevance 0.31 Pain Relevance 0.07
ET dysfunction is a major problem in the young child: the small calibre of the ET as well as its horizontal direction [5] (Figs. 3 and 4) are responsible for both the high incidence of AOM and the frequent relapses by each viral infection.
Regulation (responsible) of AOM associated with otitis media, viral infection and recurrence
2) Confidence 0.31 Published 2007 Journal Eur J Pediatr Section Body Doc Link PMC1876255 Disease Relevance 0.88 Pain Relevance 0
The amount of proteoglycans in culture medium was decreased by ASA, whereas type II collagen was not modified.
Neg (not) Regulation (modified) of type II collagen
3) Confidence 0.22 Published 1992 Journal J. Rheumatol. Section Abstract Doc Link 1433013 Disease Relevance 0.09 Pain Relevance 0.27
Pneumococcal vaccination has little beneficial effects on recurrent AOM and its use in infants needs further studies.
Neg (little) Regulation (effects) of AOM associated with otitis media
4) Confidence 0.19 Published 2007 Journal Eur J Pediatr Section Abstract Doc Link PMC1876255 Disease Relevance 1.20 Pain Relevance 0.03
Indeed, a meta-analysis of 5,400 children, aged 6 months to 18 years, and collected from 33 randomized trials concluded that there was a significant but modest impact of antibiotics on the primary control of AOM [45].
Regulation (control) of AOM associated with otitis media
5) Confidence 0.19 Published 2007 Journal Eur J Pediatr Section Body Doc Link PMC1876255 Disease Relevance 1.06 Pain Relevance 0
These data show that Col11a1 is essential for skeletal morphogenesis because it controls type II collagen fibrillogenesis, chondrocyte maturation and bone mineralization [46,47].
Regulation (controls) of type II collagen in chondrocyte
6) Confidence 0.07 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2876060 Disease Relevance 1.46 Pain Relevance 0.08
The FFQ and NRS Caregiver are newly composed questionnaires to assess the influence of recurrent AOM on the caregiver and family.
Regulation (influence) of AOM associated with otitis media
7) Confidence 0.01 Published 2007 Journal Qual Life Res Section Body Doc Link PMC2039822 Disease Relevance 0.43 Pain Relevance 0
However, estimating responsiveness for the interval of 7–14 months, in which AOM frequency was not affected by recall bias since al episodes were physician diagnosed, yielded similar results.
Neg (not) Regulation (affected) of AOM associated with otitis media
8) Confidence 0.01 Published 2007 Journal Qual Life Res Section Body Doc Link PMC2039822 Disease Relevance 0.46 Pain Relevance 0
Comparing small change with moderate to large change shows that, overall, the larger the change in AOM severity or frequency, the larger the magnitude of the change score on the questionnaires.
Regulation (change) of AOM associated with otitis media
9) Confidence 0.01 Published 2007 Journal Qual Life Res Section Body Doc Link PMC2039822 Disease Relevance 1.05 Pain Relevance 0

General Comments

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