INT97331

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Context Info
Confidence 0.45
First Reported 2001
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 20
Total Number 22
Disease Relevance 13.32
Pain Relevance 8.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Timp1) extracellular region (Timp1) proteinaceous extracellular matrix (Timp1)
Anatomy Link Frequency
lung 2
cerebrospinal fluid 1
dental pulp 1
Timp1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
metalloproteinase 528 100.00 Very High Very High Very High
headache 6 99.82 Very High Very High Very High
cytokine 129 99.60 Very High Very High Very High
fibrosis 128 99.44 Very High Very High Very High
dexamethasone 10 98.80 Very High Very High Very High
agonist 191 98.08 Very High Very High Very High
Inflammation 196 97.92 Very High Very High Very High
Central nervous system 2 94.72 High High
Potency 48 94.48 High High
carpal tunnel syndrome 2 93.92 High High
Disease Link Frequency Relevance Heat
Pulmonary Fibrosis 56 99.84 Very High Very High Very High
Epiretinal Membrane 2 99.68 Very High Very High Very High
Contracture 8 99.64 Very High Very High Very High
Fibrosis 88 99.48 Very High Very High Very High
Hypoxia 79 99.36 Very High Very High Very High
Dupuytren's Disease 16 99.36 Very High Very High Very High
Disease 30 98.16 Very High Very High Very High
Diabetes Mellitus 125 98.00 Very High Very High Very High
Stress 12 97.96 Very High Very High Very High
INFLAMMATION 221 97.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
TAA treatment increased transcription of both MMPs and TIMPs, but only TIMPs showed increased translation.
Positive_regulation (increased) of TIMP associated with metalloproteinase
1) Confidence 0.45 Published 2010 Journal Journal of Korean Medical Science Section Abstract Doc Link PMC2844613 Disease Relevance 0.66 Pain Relevance 0.37
Of the 15 inflammatory genes tested, 12 genes (C1-INH, CCR5, CD44, CHI3L1, HSPB1, JAK3, LGALS3, LGALS3BP, LAMA5, PEDF, STAT3, TIMP1) were reproducibly upregulated at 3 months (Figures 4 &5).
Positive_regulation (upregulated) of TIMP1 associated with inflammation
2) Confidence 0.40 Published 2008 Journal BMC Med Genomics Section Body Doc Link PMC2442612 Disease Relevance 0.33 Pain Relevance 0.12
TIMP-1 (tissue inhibitor of metallopeptidase1) expression is regulated through STAT3 [38] and TIMP-1 is induced in the epiretinal membranes of Type 1 and Type 2 diabetic patients [39].
Positive_regulation (induced) of TIMP-1 associated with epiretinal membrane and diabetes mellitus
3) Confidence 0.40 Published 2008 Journal BMC Med Genomics Section Body Doc Link PMC2442612 Disease Relevance 1.14 Pain Relevance 0.23
There was an increase in TIMP-1, TIMP-2 and TGF-?
Positive_regulation (increase) of TIMP-1
4) Confidence 0.29 Published 2009 Journal Mol Biol Rep Section Body Doc Link PMC2831180 Disease Relevance 0.26 Pain Relevance 0
The activities of TIMP-1 or TIMP-23,44-46 were reported to increase in pulmonary fibrosis, especially in the acute phase of pulmonary fibrosis or acute lung injury model.
Positive_regulation (increase) of TIMP in lung associated with fibrosis, metalloproteinase, adult respiratory distress syndrome and pulmonary fibrosis
5) Confidence 0.28 Published 2009 Journal Yonsei Medical Journal Section Body Doc Link PMC2649867 Disease Relevance 0.72 Pain Relevance 0.93
Concomitantly to the increase of TIMP-1, TGF-?
Positive_regulation (increase) of TIMP-1
6) Confidence 0.22 Published 2010 Journal PPAR Research Section Body Doc Link PMC2957135 Disease Relevance 0.21 Pain Relevance 0.33
Consistently, the levels of mRNA for MMP-3 and -13 were reduced by 50% and by 10%, respectively, whereas those for TIMP-1 were upregulated by 65% (Table 2).
Positive_regulation (upregulated) of TIMP-1 associated with metalloproteinase
7) Confidence 0.22 Published 2010 Journal PPAR Research Section Body Doc Link PMC2957135 Disease Relevance 0 Pain Relevance 0.69
The activities of TIMP-1 or TIMP-23,44-46 were reported to increase in pulmonary fibrosis, especially in the acute phase of pulmonary fibrosis or acute lung injury model.
Positive_regulation (increase) of TIMP in lung associated with fibrosis, metalloproteinase, adult respiratory distress syndrome and pulmonary fibrosis
8) Confidence 0.20 Published 2009 Journal Yonsei Medical Journal Section Body Doc Link PMC2649867 Disease Relevance 0.72 Pain Relevance 0.93
It was postulated that this was because of destruction or neutralization of the cytokines by tissue and bacterial matrix metalloproteinases (MMPs).32 One reason that ACCS may have been effective in this model in physiological doses of cytokines is because of high levels of TIMP-1 and TIMP-2, known natural inhibitors to MMPs.8 These high levels of TIMPs improve the MMP/TIMP ratio, which has been reported to improve healing in chronic wounds.33 Tissue bacterial bioburden remained high (>105 CFUs/g of tissue) in both treated and control wounds.
Positive_regulation (levels) of TIMP-1 associated with injury, metalloproteinase and cytokine
9) Confidence 0.17 Published 2008 Journal Eplasty Section Body Doc Link PMC2323202 Disease Relevance 0.72 Pain Relevance 0.28
Patients with Dupuytren's contracture presented with a TIMP-1 concentration of 437 +/- 160 ng/ml, a significantly higher TIMP-1 concentration than that seen in the control patients, who had a concentration of 321 +/- 70 ng/ml (p < 0.05).
Positive_regulation (concentration) of TIMP-1 associated with dupuytren's disease and contracture
10) Confidence 0.15 Published 2003 Journal Plast. Reconstr. Surg. Section Abstract Doc Link 14504511 Disease Relevance 1.20 Pain Relevance 0.27
Patients with Dupuytren's contracture presented with a TIMP-1 concentration of 437 +/- 160 ng/ml, a significantly higher TIMP-1 concentration than that seen in the control patients, who had a concentration of 321 +/- 70 ng/ml (p < 0.05).
Positive_regulation (concentration) of TIMP-1 associated with dupuytren's disease and contracture
11) Confidence 0.15 Published 2003 Journal Plast. Reconstr. Surg. Section Abstract Doc Link 14504511 Disease Relevance 1.19 Pain Relevance 0.28
There were no major effects on MMP-13 mRNA levels by the GLP-2 agonists, under either ambient oxygen status; however, there were interesting statistically significant increases in mRNA levels for TIMP 1, 2, and 3 in hypoxic animals treated with GLP-2-MMB, but not native GLP-2 (data not shown).


Positive_regulation (increases) of TIMP associated with hypoxia and agonist
12) Confidence 0.15 Published 2010 Journal Gastroenterology Research and Practice Section Body Doc Link PMC2952794 Disease Relevance 0.74 Pain Relevance 0.24
In aggregate, these findings would suggest a slight increase in collagen I synthesis with either GLP-2 ligand and, interestingly, a distinct increase in TIMP activity with the long-acting GLP-2 MMB under the stress of hypoxia.
Positive_regulation (increase) of TIMP associated with stress and hypoxia
13) Confidence 0.15 Published 2010 Journal Gastroenterology Research and Practice Section Body Doc Link PMC2952794 Disease Relevance 0.82 Pain Relevance 0.04
1 decreased global MMP and MMP-13 activities by 66% and by 19%, respectively, (Figures 4(a) and 4(b)), while increasing TIMP-1 levels by 75% (Figure 4(c)).
Positive_regulation (increasing) of TIMP-1 associated with metalloproteinase
14) Confidence 0.15 Published 2010 Journal PPAR Research Section Body Doc Link PMC2957135 Disease Relevance 0 Pain Relevance 0.64
Moreover, the mRNAs of MMP-9, a matrix metalloproteinase, and TIMP-1, tissue inhibitor 1 of matrix metalloproteinase, are upregulated 6 h after the insult [7].
Positive_regulation (upregulated) of TIMP-1 associated with metalloproteinase
15) Confidence 0.14 Published 2008 Journal BMC Mol Biol Section Body Doc Link PMC2430208 Disease Relevance 0.68 Pain Relevance 0.13
Dexa(5)-Man(10)-HSA, however, also accelerated fibrogenesis, which was paralleled by TIMP-1 mRNA induction.
Positive_regulation (induction) of TIMP-1 associated with fibrosis
16) Confidence 0.13 Published 2001 Journal Hepatology Section Abstract Doc Link 11584368 Disease Relevance 0.43 Pain Relevance 0.30
The concomitant elevation of MMP-2 and TIMP-1 may partially justify why invasiveness was not increased, but other enzymes should also be considered.


Positive_regulation (elevation) of TIMP-1
17) Confidence 0.10 Published 2009 Journal Fertil. Steril. Section Body Doc Link 18692810 Disease Relevance 0.06 Pain Relevance 0
In vivo, however, this was associated with increased collagen I and III depositions and enhanced tissue inhibitor of metalloproteinase-1 (TIMP-1) mRNA expression.
Positive_regulation (enhanced) of TIMP-1 associated with metalloproteinase
18) Confidence 0.08 Published 2001 Journal Hepatology Section Abstract Doc Link 11584368 Disease Relevance 0.83 Pain Relevance 0.52
The MMP-9/TIMP-1 ratio was significantly increased in neuro-BD group (mean +/- SD: 0.145+/-0.045) compared to (HaBD) (0.065+/-0.029; p=0.0001) and NIND patients (0.070+/-0.031; p=0.0001).
Positive_regulation (ncreased ) of TIMP-1 associated with neurological disease and metalloproteinase
19) Confidence 0.07 Published 2009 Journal Clin. Exp. Rheumatol. Section Abstract Doc Link 19796534 Disease Relevance 0.90 Pain Relevance 0.71
Elevated levels of MMP-9 and TIMP-1 in the cerebrospinal fluid of neuro-Beh├žet's disease.
Positive_regulation (levels) of TIMP-1 in cerebrospinal fluid associated with headache and disease
20) Confidence 0.07 Published 2009 Journal Clin. Exp. Rheumatol. Section Title Doc Link 19796534 Disease Relevance 0.83 Pain Relevance 0.87

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