INT97332

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Context Info
Confidence 0.44
First Reported 2001
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 3.60
Pain Relevance 1.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Timp1) extracellular region (Timp1) proteinaceous extracellular matrix (Timp1)
Anatomy Link Frequency
fibroblast 1
central vein 1
PGE2 1
Timp1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
metalloproteinase 61 100.00 Very High Very High Very High
cytokine 9 100.00 Very High Very High Very High
Inflammation 16 95.88 Very High Very High Very High
pulpitis 2 92.24 High High
fibrosis 35 74.56 Quite High
tolerance 12 69.36 Quite High
Angina 3 56.08 Quite High
Inflammatory marker 23 13.60 Low Low
aspirin 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 7 100.00 Very High Very High Very High
Necrosis 6 100.00 Very High Very High Very High
Cirrhosis 66 99.48 Very High Very High Very High
Increased Venous Pressure Under Development 1 96.56 Very High Very High Very High
Disease 4 96.24 Very High Very High Very High
INFLAMMATION 41 95.88 Very High Very High Very High
Diabetes Mellitus 24 95.48 Very High Very High Very High
Pulpitis 2 92.24 High High
Apoptosis 9 85.92 High High
Acute Coronary Syndrome 1 83.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Cells positive for MMPs and TIMPs in the portal areas and around the central vein also showed ?
Regulation (positive) of TIMP in central vein associated with metalloproteinase
1) Confidence 0.44 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2844613 Disease Relevance 1.11 Pain Relevance 0.50
In contrast, 0.5 mM NIM811 increased the expression of MMP-1 nearly two-fold (Fig. 3B) but did not affect that of TIMP-1 (Fig. 3C).
Neg (not) Regulation (affect) of TIMP-1
2) Confidence 0.11 Published 2007 Journal Liver International Section Body Doc Link PMC2156109 Disease Relevance 0.20 Pain Relevance 0.09
We found, however, no associations between abnormal glucose regulation and the levels of IL-18, MMP-9, TIMP-1, and adiponectin.
Regulation (regulation) of TIMP-1
3) Confidence 0.06 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2940874 Disease Relevance 1.27 Pain Relevance 0.17
The effects of proinflammatory cytokines (interleukin (IL)-1alpha and tumor necrosis factor-alpha (TNF-alpha)) and prostaglandin E2 (PGE2) on pulp fibroblast MMP-1 and TIMP-1 gene expression were investigated.
Spec (investigated) Regulation (effects) of TIMP-1 in fibroblast associated with necrosis, cancer and cytokine
4) Confidence 0.02 Published 2001 Journal J Endod Section Abstract Doc Link 11487149 Disease Relevance 0.54 Pain Relevance 0.29
The differential regulation of IL-1alpha or TNF-alpha-induced MMP-1 and TIMP-1 mRNA synthesis, as well as the direct upregulation of TIMP-1 gene expression by PGE2, also implied that prostaglandin may serve as a protective mechanism from excessive tissue breakdown during pulpitis.
Regulation (regulation) of TIMP-1 in PGE2 associated with pulpitis
5) Confidence 0.02 Published 2001 Journal J Endod Section Abstract Doc Link 11487149 Disease Relevance 0.47 Pain Relevance 0.34

General Comments

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