INT97333

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Context Info
Confidence 0.54
First Reported 2001
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 4.80
Pain Relevance 1.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Timp1) extracellular region (Timp1) proteinaceous extracellular matrix (Timp1)
Anatomy Link Frequency
fibroblast 2
PGE2 2
Timp1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 28 100.00 Very High Very High Very High
ischemia 40 99.68 Very High Very High Very High
fibrosis 6 96.16 Very High Very High Very High
Inflammation 30 95.88 Very High Very High Very High
pulpitis 3 92.84 High High
metalloproteinase 22 92.36 High High
Inflammatory marker 1 88.08 High High
chemokine 3 68.36 Quite High
Inflammatory response 7 65.04 Quite High
ketamine 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Necrosis 5 100.00 Very High Very High Very High
Cancer 5 100.00 Very High Very High Very High
Infarction 62 99.68 Very High Very High Very High
Cv Unclassified Under Development 39 99.68 Very High Very High Very High
Ganglion Cysts 3 99.48 Very High Very High Very High
Epiretinal Membrane 1 98.04 Very High Very High Very High
Diabetes Mellitus 58 96.36 Very High Very High Very High
Disease 5 96.24 Very High Very High Very High
Fibrosis 8 96.16 Very High Very High Very High
INFLAMMATION 38 95.88 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, just like the Casp4 gene, since the difference in two groups is not considerable, it is difficult to conclude that propofol plays an important role for the Timp1 gene expression in the ischemia-reperfusion model.
Regulation (role) of Gene_expression (expression) of Timp1 gene associated with ischemia
1) Confidence 0.54 Published 2010 Journal Korean Journal of Anesthesiology Section Body Doc Link PMC2872860 Disease Relevance 1.13 Pain Relevance 0.24
TIMP-1 (tissue inhibitor of metallopeptidase1) expression is regulated through STAT3 [38] and TIMP-1 is induced in the epiretinal membranes of Type 1 and Type 2 diabetic patients [39].
Regulation (regulated) of Gene_expression (expression) of TIMP-1 associated with epiretinal membrane and diabetes mellitus
2) Confidence 0.36 Published 2008 Journal BMC Med Genomics Section Body Doc Link PMC2442612 Disease Relevance 1.14 Pain Relevance 0.23
1 down-regulation caused by SDF-1 was associated with decreased collagen accumulation and down-regulated TIMP-1 expression in the infarction area.
Regulation (regulation) of Gene_expression (expression) of TIMP-1 associated with infarction
3) Confidence 0.26 Published 2009 Journal Mol Biol Rep Section Body Doc Link PMC2831180 Disease Relevance 0.65 Pain Relevance 0.08
1 down-regulation caused by SDF-1 was associated with decreased collagen accumulation and down-regulated TIMP-1 expression in the infarction area.
Regulation (regulated) of Gene_expression (expression) of TIMP-1 associated with infarction
4) Confidence 0.26 Published 2009 Journal Mol Biol Rep Section Body Doc Link PMC2831180 Disease Relevance 0.64 Pain Relevance 0.08
The effects of proinflammatory cytokines (interleukin (IL)-1alpha and tumor necrosis factor-alpha (TNF-alpha)) and prostaglandin E2 (PGE2) on pulp fibroblast MMP-1 and TIMP-1 gene expression were investigated.
Spec (investigated) Regulation (effects) of Gene_expression (expression) of TIMP-1 in fibroblast associated with necrosis, cancer and cytokine
5) Confidence 0.05 Published 2001 Journal J Endod Section Abstract Doc Link 11487149 Disease Relevance 0.54 Pain Relevance 0.29
The differential regulation of IL-1alpha or TNF-alpha-induced MMP-1 and TIMP-1 mRNA synthesis, as well as the direct upregulation of TIMP-1 gene expression by PGE2, also implied that prostaglandin may serve as a protective mechanism from excessive tissue breakdown during pulpitis.
Regulation (regulation) of Gene_expression (synthesis) of TIMP-1 in PGE2 associated with pulpitis
6) Confidence 0.05 Published 2001 Journal J Endod Section Abstract Doc Link 11487149 Disease Relevance 0.47 Pain Relevance 0.34
These cytokines did not affect the expression of TIMP-1 or TIMP-2.
Neg (not) Regulation (affect) of Gene_expression (expression) of TIMP-1 associated with cytokine
7) Confidence 0.03 Published 2006 Journal J Endod Section Abstract Doc Link 16934628 Disease Relevance 0.22 Pain Relevance 0.45

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