INT97333

Context Info Confidence 0.54 First Reported 2001 Last Reported 2010 Negated 1 Speculated 1 Reported most in Body Documents 6 Total Number 7 Disease Relevance 4.80 Pain Relevance 1.71

aging (Timp1) extracellular region (Timp1) proteinaceous extracellular matrix (Timp1)

Anatomy Link Frequency fibroblast 2 PGE2 2 Timp1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat cytokine 28 100.00 ischemia 40 99.68 fibrosis 6 96.16 Inflammation 30 95.88 pulpitis 3 92.84 metalloproteinase 22 92.36 Inflammatory marker 1 88.08 chemokine 3 68.36 Inflammatory response 7 65.04 ketamine 5 5.00

Disease Link Frequency Relevance Heat Necrosis 5 100.00 Cancer 5 100.00 Infarction 62 99.68 Cv Unclassified Under Development 39 99.68 Ganglion Cysts 3 99.48 Epiretinal Membrane 1 98.04 Diabetes Mellitus 58 96.36 Disease 5 96.24 Fibrosis 8 96.16 INFLAMMATION 38 95.88

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

However, just like the Casp4 gene, since the difference in two groups is not considerable, it is difficult to conclude that propofol plays an important role for the Timp1 gene expression in the ischemia-reperfusion model.

Regulation (role) of Gene_expression (expression) of Timp1 gene associated with ischemia

1) Confidence 0.54 Published 2010 Journal Korean Journal of Anesthesiology Section Body Doc Link PMC2872860 Disease Relevance 1.13 Pain Relevance 0.24

TIMP-1 (tissue inhibitor of metallopeptidase1) expression is regulated through STAT3 [38] and TIMP-1 is induced in the epiretinal membranes of Type 1 and Type 2 diabetic patients [39].

Regulation (regulated) of Gene_expression (expression) of TIMP-1 associated with epiretinal membrane and diabetes mellitus

2) Confidence 0.36 Published 2008 Journal BMC Med Genomics Section Body Doc Link PMC2442612 Disease Relevance 1.14 Pain Relevance 0.23

1 down-regulation caused by SDF-1 was associated with decreased collagen accumulation and down-regulated TIMP-1 expression in the infarction area.

Regulation (regulation) of Gene_expression (expression) of TIMP-1 associated with infarction

3) Confidence 0.26 Published 2009 Journal Mol Biol Rep Section Body Doc Link PMC2831180 Disease Relevance 0.65 Pain Relevance 0.08

1 down-regulation caused by SDF-1 was associated with decreased collagen accumulation and down-regulated TIMP-1 expression in the infarction area.

Regulation (regulated) of Gene_expression (expression) of TIMP-1 associated with infarction

4) Confidence 0.26 Published 2009 Journal Mol Biol Rep Section Body Doc Link PMC2831180 Disease Relevance 0.64 Pain Relevance 0.08

The effects of proinflammatory cytokines (interleukin (IL)-1alpha and tumor necrosis factor-alpha (TNF-alpha)) and prostaglandin E2 (PGE2) on pulp fibroblast MMP-1 and TIMP-1 gene expression were investigated.

Spec (investigated) Regulation (effects) of Gene_expression (expression) of TIMP-1 in fibroblast associated with necrosis, cancer and cytokine

5) Confidence 0.05 Published 2001 Journal J Endod Section Abstract Doc Link 11487149 Disease Relevance 0.54 Pain Relevance 0.29

The differential regulation of IL-1alpha or TNF-alpha-induced MMP-1 and TIMP-1 mRNA synthesis, as well as the direct upregulation of TIMP-1 gene expression by PGE2, also implied that prostaglandin may serve as a protective mechanism from excessive tissue breakdown during pulpitis.

Regulation (regulation) of Gene_expression (synthesis) of TIMP-1 in PGE2 associated with pulpitis

6) Confidence 0.05 Published 2001 Journal J Endod Section Abstract Doc Link 11487149 Disease Relevance 0.47 Pain Relevance 0.34

These cytokines did not affect the expression of TIMP-1 or TIMP-2.

Neg (not) Regulation (affect) of Gene_expression (expression) of TIMP-1 associated with cytokine

7) Confidence 0.03 Published 2006 Journal J Endod Section Abstract Doc Link 16934628 Disease Relevance 0.22 Pain Relevance 0.45

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