INT97334

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Context Info
Confidence 0.49
First Reported 2001
Last Reported 2010
Negated 2
Speculated 0
Reported most in Abstract
Documents 11
Total Number 12
Disease Relevance 7.44
Pain Relevance 4.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Timp1) extracellular region (Timp1) proteinaceous extracellular matrix (Timp1)
Anatomy Link Frequency
PGE2 8
dental pulp 4
liver 2
Timp1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 29 100.00 Very High Very High Very High
metalloproteinase 140 99.08 Very High Very High Very High
fibrosis 68 95.92 Very High Very High Very High
pulpitis 6 95.32 Very High Very High Very High
COX-2 inhibitor 2 94.96 High High
Inflammation 22 80.96 Quite High
cva 7 77.92 Quite High
carpal tunnel syndrome 1 58.64 Quite High
anesthesia 2 5.00 Very Low Very Low Very Low
alcohol 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Dupuytren's Disease 8 100.00 Very High Very High Very High
Contracture 4 100.00 Very High Very High Very High
Pancreatic Cancer 1 99.84 Very High Very High Very High
Fibrosis 50 98.28 Very High Very High Very High
Cirrhosis 96 98.08 Very High Very High Very High
Apoptosis 10 95.68 Very High Very High Very High
Fibroma 3 95.40 Very High Very High Very High
Pulpitis 6 95.32 Very High Very High Very High
Hepatocellular Cancer 2 94.64 High High
Disease 14 93.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To this respect, our results demonstrate that increased TIMP expression is more critical than MMPs in TAA-induced fibrogenesis.
Positive_regulation (increased) of Gene_expression (expression) of TIMP associated with fibrosis and metalloproteinase
1) Confidence 0.49 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2844613 Disease Relevance 0.90 Pain Relevance 0.59
Thus, overexpression of TIMPs inhibits the ECM-degrading functions of MMPs may explain the establishment and maintenance of liver fibrosis.
Positive_regulation (overexpression) of Gene_expression (overexpression) of TIMP in liver associated with fibrosis, cirrhosis and metalloproteinase
2) Confidence 0.49 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2844613 Disease Relevance 0.90 Pain Relevance 0.63
Interestingly, TIMP-1 overexpression in pancreatic cancer cells reduced angiogenesis and cell implantation, this anti-angiogenic activity of TIMP-1 involved in part MMP-inhibition [33].
Positive_regulation (overexpression) of Gene_expression (overexpression) of TIMP-1 associated with pancreatic cancer
3) Confidence 0.27 Published 2009 Journal Mol Biol Rep Section Body Doc Link PMC2831180 Disease Relevance 0.15 Pain Relevance 0.07
TIMP-1 and TIMP-2 could be detected in tissue of patients with Dupuytren's contracture, with an accumulation in proliferative areas.
Positive_regulation (accumulation) of Gene_expression (detected) of TIMP-1 associated with dupuytren's disease and contracture
4) Confidence 0.15 Published 2003 Journal Plast. Reconstr. Surg. Section Abstract Doc Link 14504511 Disease Relevance 1.29 Pain Relevance 0.26
Another target of MMP inhibition has been demonstrated in animal models of adenovirus-mediated TIMP gene transfer [46].
Positive_regulation (transfer) of Gene_expression (transfer) of TIMP
5) Confidence 0.13 Published 2004 Journal Curr Control Trials Cardiovasc Med Section Body Doc Link PMC526392 Disease Relevance 0.80 Pain Relevance 0.41
NIM811, as well as cyclosporine, suppressed the transcription and synthesis of collagen and stimulated the production of MMP-1 with a concomitant enhancement of collagenase activity, although it did not change the expression of TIMP-1.
Neg (not) Positive_regulation (change) of Gene_expression (expression) of TIMP-1
6) Confidence 0.11 Published 2007 Journal Liver International Section Abstract Doc Link PMC2156109 Disease Relevance 0.78 Pain Relevance 0.11
These results suggested that cytokine-stimulated MMP-1 and TIMP-1 gene expression in dental pulp fibroblasts was mediated, at least in part, by a prostaglandin-dependent pathway.
Positive_regulation (mediated) of Gene_expression (expression) of TIMP-1 in dental pulp associated with cytokine
7) Confidence 0.08 Published 2001 Journal J Endod Section Abstract Doc Link 11487149 Disease Relevance 0.40 Pain Relevance 0.36
The differential regulation of IL-1alpha or TNF-alpha-induced MMP-1 and TIMP-1 mRNA synthesis, as well as the direct upregulation of TIMP-1 gene expression by PGE2, also implied that prostaglandin may serve as a protective mechanism from excessive tissue breakdown during pulpitis.
Positive_regulation (upregulation) of Gene_expression (expression) of TIMP-1 in PGE2 associated with pulpitis
8) Confidence 0.06 Published 2001 Journal J Endod Section Abstract Doc Link 11487149 Disease Relevance 0.46 Pain Relevance 0.31
These results suggested that cytokine-stimulated MMP-1 and TIMP-1 gene expression in dental pulp fibroblasts was mediated, at least in part, by a prostaglandin-dependent pathway.
Positive_regulation (cytokine-stimulated) of Gene_expression (expression) of TIMP-1 in dental pulp associated with cytokine
9) Confidence 0.06 Published 2001 Journal J Endod Section Abstract Doc Link 11487149 Disease Relevance 0.41 Pain Relevance 0.36
Exogenous PGE2, however, upregulated TIMP-1 mRNA synthesis but not MMP-1.
Neg (not) Positive_regulation (upregulated) of Gene_expression (synthesis) of TIMP-1 in PGE2
10) Confidence 0.06 Published 2001 Journal J Endod Section Abstract Doc Link 11487149 Disease Relevance 0.49 Pain Relevance 0.30
Furthermore, cytokine stimulation of MMP-1 and TIMP-1 gene expressions can be enhanced or blocked by indomethacin, respectively, and reversed by exogenous PGE2.
Positive_regulation (stimulation) of Gene_expression (expressions) of TIMP-1 in PGE2 associated with cytokine
11) Confidence 0.06 Published 2001 Journal J Endod Section Abstract Doc Link 11487149 Disease Relevance 0.44 Pain Relevance 0.36
Furthermore, cytokine stimulation of MMP-1 and TIMP-1 gene expressions can be enhanced or blocked by indomethacin, respectively, and reversed by exogenous PGE2.
Positive_regulation (enhanced) of Gene_expression (expressions) of TIMP-1 in PGE2 associated with cytokine
12) Confidence 0.06 Published 2001 Journal J Endod Section Abstract Doc Link 11487149 Disease Relevance 0.43 Pain Relevance 0.36

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