INT97367

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Context Info
Confidence 0.78
First Reported 2001
Last Reported 2010
Negated 11
Speculated 3
Reported most in Abstract
Documents 243
Total Number 270
Disease Relevance 132.97
Pain Relevance 286.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
neurons 40
SAN 14
microglia 14
nociceptors 10
ganglia 10
Nav1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
nav1.8 2788 100.00 Very High Very High Very High
sodium channel 2756 100.00 Very High Very High Very High
nav1.3 2346 100.00 Very High Very High Very High
dorsal root ganglion 2079 100.00 Very High Very High Very High
Nav1.2 1847 100.00 Very High Very High Very High
Nav1.6 1646 100.00 Very High Very High Very High
tetrodotoxin 1140 100.00 Very High Very High Very High
Nav1.1 686 100.00 Very High Very High Very High
Action potential 681 100.00 Very High Very High Very High
Nav1.9 302 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 2195 100.00 Very High Very High Very High
Frailty 21 99.92 Very High Very High Very High
Targeted Disruption 238 99.88 Very High Very High Very High
Nociception 1003 99.84 Very High Very High Very High
Myocardial Infarction 98 99.84 Very High Very High Very High
Neuropathic Pain 1036 99.80 Very High Very High Very High
Inflammatory Pain 87 99.78 Very High Very High Very High
Pain 1765 99.76 Very High Very High Very High
Demyelinating Disease 132 99.76 Very High Very High Very High
Injury 4402 99.64 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Expression of Nav1.1 in rat retinal AII amacrine cells.
Gene_expression (Expression) of Nav1 in amacrine cells associated with nav1.1
1) Confidence 0.78 Published 2007 Journal Neurosci. Lett. Section Title Doc Link 17709186 Disease Relevance 0.17 Pain Relevance 1.74
Like RGCs, certain subsets of retinal amacrine cells, including AII amacrine cells, generate tetrodotoxin (TTX)-sensitive action potentials in response to light; however, the Nav subtypes expressed in these cells have not been identified.
Gene_expression (expressed) of Nav in RGCs associated with action potential, tetrodotoxin and sodium channel
2) Confidence 0.78 Published 2007 Journal Neurosci. Lett. Section Abstract Doc Link 17709186 Disease Relevance 0.16 Pain Relevance 1.82
In retinal ganglion cells (RGCs), the expression of various types of voltage-gated sodium channel (Nav) alpha-subunits (Nav1.1, Nav1.2, Nav1.3, and Nav1.6) has been reported.
Gene_expression (expression) of Nav1 in retinal ganglion cells associated with ganglion cysts, nav1.3, nav1.1, nav1.2, sodium channel and nav1.6
3) Confidence 0.78 Published 2007 Journal Neurosci. Lett. Section Abstract Doc Link 17709186 Disease Relevance 0.15 Pain Relevance 1.54
We examined the Nav subtypes expressed in rat retinal amacrine cells by in situ hybridization (ISH) using RNA probes specific for TTX-sensitive Na(v)s (Nav1.1, Nav1.2, Nav1.3, Nav1.6, and Nav1.7).
Gene_expression (expressed) of Nav in amacrine cells associated with nav1.3, tetrodotoxin, nav1.1, nav1.2, sodium channel, nav1.7 and nav1.6
4) Confidence 0.78 Published 2007 Journal Neurosci. Lett. Section Abstract Doc Link 17709186 Disease Relevance 0.16 Pain Relevance 1.90
Therefore, we combined ISH with immunohistochemistry and discovered that most of the PV-immunoreactive cells located at the INL/IPL border express Nav1.1.
Gene_expression (express) of Nav1 in IPL associated with nav1.1
5) Confidence 0.78 Published 2007 Journal Neurosci. Lett. Section Abstract Doc Link 17709186 Disease Relevance 0.13 Pain Relevance 1.69
In retinal ganglion cells (RGCs), the expression of various types of voltage-gated sodium channel (Nav) alpha-subunits (Nav1.1, Nav1.2, Nav1.3, and Nav1.6) has been reported.
Gene_expression (expression) of Nav1 in retinal ganglion cells associated with ganglion cysts, nav1.3, nav1.1, nav1.2, sodium channel and nav1.6
6) Confidence 0.78 Published 2007 Journal Neurosci. Lett. Section Abstract Doc Link 17709186 Disease Relevance 0.15 Pain Relevance 1.55
In retinal ganglion cells (RGCs), the expression of various types of voltage-gated sodium channel (Nav) alpha-subunits (Nav1.1, Nav1.2, Nav1.3, and Nav1.6) has been reported.
Gene_expression (expression) of Nav1 in retinal ganglion cells associated with ganglion cysts, nav1.3, nav1.1, nav1.2, sodium channel and nav1.6
7) Confidence 0.78 Published 2007 Journal Neurosci. Lett. Section Abstract Doc Link 17709186 Disease Relevance 0.16 Pain Relevance 1.56
Interestingly, Nav1.1 was expressed not only in the GCL, but also in the inner nuclear layer (INL).
Gene_expression (expressed) of Nav1 in inner nuclear layer associated with nav1.1
8) Confidence 0.78 Published 2007 Journal Neurosci. Lett. Section Abstract Doc Link 17709186 Disease Relevance 0.17 Pain Relevance 2.01
Our results show that AII amacrine cells express Nav1.1.
Gene_expression (express) of Nav1 in amacrine cells associated with nav1.1
9) Confidence 0.78 Published 2007 Journal Neurosci. Lett. Section Abstract Doc Link 17709186 Disease Relevance 0.08 Pain Relevance 1.65
In retinal ganglion cells (RGCs), the expression of various types of voltage-gated sodium channel (Nav) alpha-subunits (Nav1.1, Nav1.2, Nav1.3, and Nav1.6) has been reported.
Gene_expression (expression) of Nav1 in retinal ganglion cells associated with ganglion cysts, nav1.3, nav1.1, nav1.2, sodium channel and nav1.6
10) Confidence 0.78 Published 2007 Journal Neurosci. Lett. Section Abstract Doc Link 17709186 Disease Relevance 0.16 Pain Relevance 1.57
In rat SAN, Nav1.1 and Nav1.6 were the primary subunits, Nav1.5 and Nav1.7 were weakly expressed, and Nav1.2 and Nav1.3 were not found to be present.
Gene_expression (present) of Nav1 in SAN associated with nav1.3, nav1.1, nav1.2, nav1.7 and nav1.6
11) Confidence 0.78 Published 2007 Journal Pflugers Arch. Section Abstract Doc Link 17273863 Disease Relevance 0.58 Pain Relevance 1.75
In rat SAN, Nav1.1 and Nav1.6 were the primary subunits, Nav1.5 and Nav1.7 were weakly expressed, and Nav1.2 and Nav1.3 were not found to be present.
Gene_expression (expressed) of Nav1 in SAN associated with nav1.3, nav1.1, nav1.2, nav1.7 and nav1.6
12) Confidence 0.78 Published 2007 Journal Pflugers Arch. Section Abstract Doc Link 17273863 Disease Relevance 0.58 Pain Relevance 1.74
We assessed SAN function and expression of Nav1.1, Nav1.2, Nav1.3, Nav1.5, Nav1.6, and Nav1.7 in sham-operated rats and rats subjected to abdominal arteriovenous shunt (volume overload)-induced HF.
Gene_expression (expression) of Nav1 in SAN associated with nav1.3, nav1.1, nav1.2, nav1.7, nav1.6 and myocardial infarction
13) Confidence 0.78 Published 2007 Journal Pflugers Arch. Section Abstract Doc Link 17273863 Disease Relevance 0.49 Pain Relevance 1.15
In rat SAN, Nav1.1 and Nav1.6 were the primary subunits, Nav1.5 and Nav1.7 were weakly expressed, and Nav1.2 and Nav1.3 were not found to be present.
Gene_expression (present) of Nav1 in SAN associated with nav1.3, nav1.1, nav1.2, nav1.7 and nav1.6
14) Confidence 0.78 Published 2007 Journal Pflugers Arch. Section Abstract Doc Link 17273863 Disease Relevance 0.58 Pain Relevance 1.75
We assessed SAN function and expression of Nav1.1, Nav1.2, Nav1.3, Nav1.5, Nav1.6, and Nav1.7 in sham-operated rats and rats subjected to abdominal arteriovenous shunt (volume overload)-induced HF.
Gene_expression (expression) of Nav1 in SAN associated with nav1.3, nav1.1, nav1.2, nav1.7, nav1.6 and myocardial infarction
15) Confidence 0.78 Published 2007 Journal Pflugers Arch. Section Abstract Doc Link 17273863 Disease Relevance 0.49 Pain Relevance 1.11
In rat SAN, Nav1.1 and Nav1.6 were the primary subunits, Nav1.5 and Nav1.7 were weakly expressed, and Nav1.2 and Nav1.3 were not found to be present.
Gene_expression (expressed) of Nav1 in SAN associated with nav1.3, nav1.1, nav1.2, nav1.7 and nav1.6
16) Confidence 0.78 Published 2007 Journal Pflugers Arch. Section Abstract Doc Link 17273863 Disease Relevance 0.58 Pain Relevance 1.74
We assessed SAN function and expression of Nav1.1, Nav1.2, Nav1.3, Nav1.5, Nav1.6, and Nav1.7 in sham-operated rats and rats subjected to abdominal arteriovenous shunt (volume overload)-induced HF.
Gene_expression (expression) of Nav1 in SAN associated with nav1.3, nav1.1, nav1.2, nav1.7, nav1.6 and myocardial infarction
17) Confidence 0.78 Published 2007 Journal Pflugers Arch. Section Abstract Doc Link 17273863 Disease Relevance 0.49 Pain Relevance 1.12
In conclusion, Nav1.1 and Nav1.6 are the dominant subunits in rat SAN, and downregulation of Nav1.1 and Nav1.6 expression contributes to HF-induced SAN dysfunction.
Gene_expression (expression) of Nav1 in SAN associated with nav1.1, nav1.6 and myocardial infarction
18) Confidence 0.78 Published 2007 Journal Pflugers Arch. Section Abstract Doc Link 17273863 Disease Relevance 0.54 Pain Relevance 1.69
We assessed SAN function and expression of Nav1.1, Nav1.2, Nav1.3, Nav1.5, Nav1.6, and Nav1.7 in sham-operated rats and rats subjected to abdominal arteriovenous shunt (volume overload)-induced HF.
Gene_expression (expression) of Nav1 in SAN associated with nav1.3, nav1.1, nav1.2, nav1.7, nav1.6 and myocardial infarction
19) Confidence 0.78 Published 2007 Journal Pflugers Arch. Section Abstract Doc Link 17273863 Disease Relevance 0.48 Pain Relevance 1.11
We assessed SAN function and expression of Nav1.1, Nav1.2, Nav1.3, Nav1.5, Nav1.6, and Nav1.7 in sham-operated rats and rats subjected to abdominal arteriovenous shunt (volume overload)-induced HF.
Gene_expression (expression) of Nav1 in SAN associated with nav1.3, nav1.1, nav1.2, nav1.7, nav1.6 and myocardial infarction
20) Confidence 0.78 Published 2007 Journal Pflugers Arch. Section Abstract Doc Link 17273863 Disease Relevance 0.49 Pain Relevance 1.15

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