INT97368

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Context Info
Confidence 0.59
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 62
Total Number 63
Disease Relevance 41.56
Pain Relevance 60.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
neurons 7
dorsal root ganglia 4
heart 4
sensory neurons 3
spinal cord 3
Nav1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
nav1.8 1259 100.00 Very High Very High Very High
dorsal root ganglion 1108 100.00 Very High Very High Very High
sodium channel 379 100.00 Very High Very High Very High
Neuropathic pain 207 100.00 Very High Very High Very High
Nav1.2 121 100.00 Very High Very High Very High
Nav1.7 81 100.00 Very High Very High Very High
Nav1.9 77 100.00 Very High Very High Very High
nav1.3 67 100.00 Very High Very High Very High
Nav1.6 41 100.00 Very High Very High Very High
Nav1.1 33 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 1136 100.00 Very High Very High Very High
Neuropathic Pain 353 100.00 Very High Very High Very High
Injury 1052 99.96 Very High Very High Very High
Pain 473 99.92 Very High Very High Very High
Targeted Disruption 75 99.88 Very High Very High Very High
Nerve Compression Syndromes 248 99.82 Very High Very High Very High
Cancer Pain 266 99.76 Very High Very High Very High
INFLAMMATION 101 99.76 Very High Very High Very High
Hypersensitivity 62 99.56 Very High Very High Very High
Nociception 124 99.08 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
After 3 days of continuous incubation with gabapentin (10-1000 microM), Nav1.2 current density was decreased dose-dependently relative to untreated cells.
Negative_regulation (decreased) of Nav1 associated with nav1.2 and gabapentin
1) Confidence 0.59 Published 2006 Journal Epilepsy Res. Section Abstract Doc Link 16621448 Disease Relevance 0 Pain Relevance 1.12
Downregulation of neuronal sodium channel subunits Nav1.1 and Nav1.6 in the sinoatrial node from volume-overloaded heart failure rat.
Negative_regulation (Downregulation) of Nav1 in sinoatrial node associated with nav1.1, sodium channel, nav1.6 and myocardial infarction
2) Confidence 0.59 Published 2007 Journal Pflugers Arch. Section Title Doc Link 17273863 Disease Relevance 0.47 Pain Relevance 1.34
Downregulation of neuronal sodium channel subunits Nav1.1 and Nav1.6 in the sinoatrial node from volume-overloaded heart failure rat.
Negative_regulation (Downregulation) of Nav1 in sinoatrial node associated with nav1.1, sodium channel, nav1.6 and myocardial infarction
3) Confidence 0.59 Published 2007 Journal Pflugers Arch. Section Title Doc Link 17273863 Disease Relevance 0.47 Pain Relevance 1.33
Bilateral downregulation of Nav1.8 in dorsal root ganglia of rats with bone cancer pain induced by inoculation with Walker 256 breast tumor cells.
Negative_regulation (downregulation) of Nav1 in dorsal root ganglia associated with pain, cancer pain, breast cancer and nav1.8
4) Confidence 0.59 Published 2010 Journal BMC Cancer Section Title Doc Link 20482896 Disease Relevance 0.56 Pain Relevance 1.16
Western blotting (Fig. 2B) revealed a significant decrease in relative Nav1.8 protein levels (percentage of normal) in bilateral DRG of tumor-bearing rats (65.6 ± 4.9 and 78.2 ± 5.4 for ipsilateral and contralateral respectively) compared to the sham group (P < 0.01).
Negative_regulation (decrease) of Nav1 associated with dorsal root ganglion, cancer and nav1.8
5) Confidence 0.59 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2894792 Disease Relevance 1.23 Pain Relevance 1.26
In addition, downregulation of Nav1.8 in ipsilateral DRG neurons in rats with cancer pain is similar to that in rats with peripheral neuropathic pain, suggesting the importance of a neuropathic element in bone cancer pain.
Negative_regulation (downregulation) of Nav1 in neurons associated with dorsal root ganglion, cancer pain, neuropathic pain, nav1.8 and bone cancer
6) Confidence 0.59 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2894792 Disease Relevance 2.09 Pain Relevance 2.10
However, we also observed downregulation of Nav1.8 in contralateral DRG neurons in tumor rats.
Negative_regulation (downregulation) of Nav1 in neurons associated with dorsal root ganglion, cancer and nav1.8
7) Confidence 0.59 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2894792 Disease Relevance 0.74 Pain Relevance 1.25
Nimodipine treatment caused a moderate reduction (approximately 30%) of the mRNA for Nav1.2 and a marked reduction (approximately 70%) of the mRNA for Nav1.3, whereas treatment with Bay K 8644 produced 90-130% increases in these same mRNAs.
Negative_regulation (reduction) of Nav1 associated with nav1.3 and nav1.2
8) Confidence 0.58 Published 2003 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 12941467 Disease Relevance 0 Pain Relevance 1.09
Nimodipine treatment caused a moderate reduction (approximately 30%) of the mRNA for Nav1.2 and a marked reduction (approximately 70%) of the mRNA for Nav1.3, whereas treatment with Bay K 8644 produced 90-130% increases in these same mRNAs.
Negative_regulation (reduction) of Nav1 associated with nav1.3 and nav1.2
9) Confidence 0.58 Published 2003 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 12941467 Disease Relevance 0 Pain Relevance 1.12
Using such a combination strategy to produce analgesia may potentially provide an improved therapeutic separation from unwanted in vivo side effects associated with blockade of either Nav1.8 or TRPV1 alone.
Negative_regulation (blockade) of Nav1 associated with nav1.8 and analgesia
10) Confidence 0.58 Published 2009 Journal J Pain Section Abstract Doc Link 19070548 Disease Relevance 0.59 Pain Relevance 1.24
State-dependent compound inhibition of Nav1.2 sodium channels using the FLIPR Vm dye: on-target and off-target effects of diverse pharmacological agents.
Negative_regulation (inhibition) of Nav1 associated with sodium channel and nav1.2
11) Confidence 0.57 Published 2006 Journal J Biomol Screen Section Title Doc Link 16234337 Disease Relevance 0.19 Pain Relevance 0.41
Our findings indicate that Nav1.8 downregulation may be one of the pathophysiological mechanisms involved in limb lengthening-induced neuropathy.
Negative_regulation (downregulation) of Nav1 in limb associated with induced neuropathy, neuropathic pain and nav1.8
12) Confidence 0.55 Published 2010 Journal J. Orthop. Res. Section Abstract Doc Link 19877286 Disease Relevance 0.52 Pain Relevance 1.16
Nav1.8 downregulation might also be a negative feedback effect of the CNS in a persistent severe chronic pain state.
Negative_regulation (downregulation) of Nav1 associated with lasting pain, central nervous system and nav1.8
13) Confidence 0.51 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2894792 Disease Relevance 0.77 Pain Relevance 1.35
For instance, inhibition or specific knock-down of tetrodotoxin-resistant (TTX-R) current Nav1.8 channel can effectively suppress neuropathic pain [3-5], while the Nav1.8 mRNA, protein and current are substantially decreased in DRG neurons in axotomized DRG neurons [6-9] or sciatic nerve injury [10].
Negative_regulation (decreased) of Nav1 in DRG associated with targeted disruption, dorsal root ganglion, tetrodotoxin, nervous system injury, neuropathic pain, sciatic nerve and nav1.8
14) Confidence 0.46 Published 2008 Journal Mol Pain Section Body Doc Link PMC2427019 Disease Relevance 1.84 Pain Relevance 1.97
Blockade of Nav1.5 (e.g.
Negative_regulation (Blockade) of Nav1.5
15) Confidence 0.44 Published 2010 Journal Journal of Molecular and Cellular Cardiology Section Body Doc Link PMC2845824 Disease Relevance 0.34 Pain Relevance 0.05
To test these possibilities, the effect of blockade of Nav1.5 and HCN4 on the spontaneous activity of right atrial preparations was investigated—if the age-dependent decrease in the intrinsic heart rate is the result of a decline in either INa or If, blockade of the corresponding ion channel should have a smaller effect on the heart rate in the older animal.
Negative_regulation (blockade) of Nav1.5 in heart
16) Confidence 0.44 Published 2010 Journal Journal of Molecular and Cellular Cardiology Section Body Doc Link PMC2845824 Disease Relevance 0.17 Pain Relevance 0.07
However, the increase in SAN tissue lacking expression of Nav1.5 cannot explain the age-dependent decrease in the intrinsic heart rate, because blockade of Nav1.5 by 2 ?
Negative_regulation (blockade) of Nav1.5 in heart
17) Confidence 0.44 Published 2010 Journal Journal of Molecular and Cellular Cardiology Section Body Doc Link PMC2845824 Disease Relevance 0.33 Pain Relevance 0.04
In whole-cell patch clamp recording, carisbamate resulted in a concentration-, voltage- and use-dependent inhibition of rat Nav1.2, with an IC(50) value of 68 microM at -67 mV.
Negative_regulation (inhibition) of Nav1 associated with nav1.2
18) Confidence 0.43 Published 2009 Journal Epilepsy Res. Section Abstract Doc Link 19013768 Disease Relevance 0.17 Pain Relevance 0.50
Nav1.8 mRNA and protein levels decreased in ipsilateral DRG neurons, especially in small neurons, concomitantly with the occurrence of stable ambulatory-evoked pain and mechanical hyperalgesia.
Negative_regulation (decreased) of Nav1 in neurons associated with pain, dorsal root ganglion, hyperalgesia and nav1.8
19) Confidence 0.43 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2894792 Disease Relevance 1.42 Pain Relevance 1.79
Bilateral downregulation of Nav1.8 in dorsal root ganglia of rats with bone cancer pain induced by inoculation with Walker 256 breast tumor cells

Background

Negative_regulation (downregulation) of Nav1 in dorsal root ganglia associated with cancer pain, breast cancer, nav1.8 and bone cancer
20) Confidence 0.43 Published 2010 Journal BMC Cancer Section Title Doc Link PMC2894792 Disease Relevance 1.10 Pain Relevance 1.27

General Comments

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