INT97374

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Context Info
Confidence 0.75
First Reported 2001
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 7
Disease Relevance 10.27
Pain Relevance 0.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Egln3) cytoplasm (Egln3)
Anatomy Link Frequency
neurons 1
Egln3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
c fibre 1 87.24 High High
unmyelinated 1 86.88 High High
Nav1.9 3 75.00 Quite High
nav1.8 3 75.00 Quite High
sodium channel 2 75.00 Quite High
tetrodotoxin 1 68.80 Quite High
Neuronal excitability 1 62.48 Quite High
Neuropeptide 3 25.00 Low Low
isoflurane 24 5.00 Very Low Very Low Very Low
anesthesia 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypoxia 264 99.32 Very High Very High Very High
Hyperoxia 660 97.06 Very High Very High Very High
Sprains And Strains 444 96.56 Very High Very High Very High
Ocular Toxicity (including Many Sub-types) 324 96.24 Very High Very High Very High
Disease Progression 24 92.48 High High
Cancer 12 90.72 High High
Retinal Neovascularization 12 70.88 Quite High
Disease 36 26.16 Quite Low
Retinopathy 108 23.28 Low Low
Rheumatoid Arthritis 96 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These increases in Egln3 expression may be a result of the response to relative hypoxia, particularly at the later time point of OIR, rather than in response to hyperoxic exposure.
Gene_expression (expression) of Egln3 associated with hypoxia and ocular toxicity (including many sub-types)
1) Confidence 0.75 Published 2009 Journal J Ocul Biol Dis Infor Section Body Doc Link PMC2821581 Disease Relevance 1.63 Pain Relevance 0
At the later time points of P20 (rat) and P18 (mouse), Egln3 expression increased by 3.0- and 5.3-fold, respectively.
Gene_expression (expression) of Egln3
2) Confidence 0.75 Published 2009 Journal J Ocul Biol Dis Infor Section Body Doc Link PMC2821581 Disease Relevance 1.62 Pain Relevance 0
Differential expression of four genes: Egln3, Bnip3, Slc16a3, and Hk2 were selected for confirmation by qRT-PCR on RNA pools identical to those used in the Affymetrix microarray.
Gene_expression (expression) of Egln3
3) Confidence 0.75 Published 2009 Journal J Ocul Biol Dis Infor Section Body Doc Link PMC2821581 Disease Relevance 1.67 Pain Relevance 0
There are three prolyl hydroxylases: PHD1, PHD2, and PHD3, all of which have been shown to have different functions in regulating HIF-1?
Gene_expression (three) of PHD3
4) Confidence 0.65 Published 2009 Journal J Ocul Biol Dis Infor Section Body Doc Link PMC2821581 Disease Relevance 1.46 Pain Relevance 0
Those in the SD list were more strongly regulated by cyclic hyperoxia and represented 18 of the top 20 downregulated genes, compared with seven of the top 20 downregulated genes in the F344 list. qRT-PCR analysis of expression levels for Egln3, Bnip3, Slc16a3, and Hk2 (Fig. 2) using RNA pools identical to those used in the microarray analysis confirmed the strain-dependent difference in regulation of these genes by hyperoxia.
Gene_expression (expression) of Egln3 associated with hyperoxia and sprains and strains
5) Confidence 0.65 Published 2009 Journal J Ocul Biol Dis Infor Section Body Doc Link PMC2821581 Disease Relevance 2.13 Pain Relevance 0
Differential expression of four genes: Egln3, Bnip3, Slc16a3, and Hk2 were selected for confirmation by qRT-PCR on RNA pools identical to those used in the Affymetrix microarray.
Gene_expression (selected) of Egln3
6) Confidence 0.58 Published 2009 Journal J Ocul Biol Dis Infor Section Body Doc Link PMC2821581 Disease Relevance 1.76 Pain Relevance 0
At E17, almost all Na(v)1.8-expressing neurons also express the high-affinity NGF receptor TrkA, and only a small proportion bind to IB4, a marker for c-ret-expressing (glial-derived neurotrophic factor-responsive) neurons.
Gene_expression (expressing) of factor-responsive in neurons
7) Confidence 0.02 Published 2001 Journal J. Neurosci. Section Abstract Doc Link 11487631 Disease Relevance 0 Pain Relevance 0.75

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