INT97375

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Context Info
Confidence 0.67
First Reported 2001
Last Reported 2008
Negated 0
Speculated 1
Reported most in Abstract
Documents 5
Total Number 6
Disease Relevance 2.92
Pain Relevance 3.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Scn10a) transmembrane transport (Scn10a)
Anatomy Link Frequency
joint 2
trigeminal ganglion 2
ND7/23 2
dorsal root ganglia 2
Scn10a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammatory mediators 2 98.64 Very High Very High Very High
Nav1.9 3 97.60 Very High Very High Very High
Inflammation 4 97.28 Very High Very High Very High
sodium channel 20 97.00 Very High Very High Very High
nav1.8 3 96.64 Very High Very High Very High
Pain 9 96.52 Very High Very High Very High
dorsal root ganglion 1 94.88 High High
fifth nerve 2 94.72 High High
tetrodotoxin 8 94.48 High High
IPN 4 94.28 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 6 98.44 Very High Very High Very High
Arthralgia 4 96.76 Very High Very High Very High
Injury 7 95.84 Very High Very High Very High
Inflammatory Pain 4 94.28 High High
Ganglion Cysts 4 93.92 High High
Neuropathic Pain 6 93.08 High High
Pain 3 91.00 High High
Nociception 3 85.84 High High
Nervous System Injury 1 78.72 Quite High
Hypersensitivity 5 68.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This suggests that other regulatory proteins are required for normal levels of Na(V)1.8 expression.
Positive_regulation (required) of Gene_expression (expression) of Na(V)1.8
1) Confidence 0.67 Published 2003 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 12591166 Disease Relevance 0.18 Pain Relevance 0.48
Using Northern blot analysis and membrane potential measurement, several siRNAs were identified that were capable of a highly-selective attenuation of Na(V)1.8 message as well as functional expression in clonal ND7/23 cells which were stably transfected with the rat Na(V)1.8 gene.
Positive_regulation (transfected) of Gene_expression (expression) of Na(V)1.8 in ND7/23
2) Confidence 0.67 Published 2007 Journal Neuroscience Section Abstract Doc Link 17367951 Disease Relevance 0.64 Pain Relevance 0.66
Expression of both Na(v)1.8 and Na(v)1.9 increases with age, beginning at embryonic day (E) 15 and E17, respectively, and reaching adult levels by postnatal day 7.
Positive_regulation (increases) of Gene_expression (Expression) of Na(v)1.8
3) Confidence 0.49 Published 2001 Journal J. Neurosci. Section Abstract Doc Link 11487631 Disease Relevance 0 Pain Relevance 0.84
In the present study, the expression of Na(V)1.7, Na(V)1.8 and Na(V)1.9 was examined over a 28 day timecourse during a rat model of FCA-induced chronic inflammatory joint pain.
Spec (examined) Positive_regulation (examined) of Spec (examined) Gene_expression (expression) of Na(V)1.8 in joint associated with pain, arthralgia and inflammation
4) Confidence 0.49 Published 2008 Journal Eur J Pain Section Abstract Doc Link 17950013 Disease Relevance 0.60 Pain Relevance 0.68
Previous work has revealed acute administration of inflammatory mediators, such as Freund's complete adjuvant (FCA) or carrageenan caused an upregulation in the levels of Na(V)1.7 and Na(V)1.8 protein in DRG (dorsal root ganglia) tissue up to 4 days post-insult.
Positive_regulation (upregulation) of Gene_expression (levels) of Na(V)1.8 in dorsal root ganglia associated with inflammatory mediators
5) Confidence 0.49 Published 2008 Journal Eur J Pain Section Abstract Doc Link 17950013 Disease Relevance 0.59 Pain Relevance 0.67
Investigations of gene expression changes in injured trigeminal ganglion neurons of animals with behavioral signs of neuropathic pain demonstrated that the sodium channel alpha-subunit Na(v)1.3-absent in sham-operated animals-was expressed to a limited extent. mRNAs for Na(v)1.8 and Na(v)1.9 were reduced both with respect to proportions of expressing neurons and to intensities, whereas the beta 3 subunit was markedly upregulated. mRNA levels of p11, a regulatory factor that facilitates the surface expression of Na(v)1.8, were unchanged.
Positive_regulation (facilitates) of Gene_expression (expression) of Na(v)1.8 in trigeminal ganglion associated with ganglion cysts, sodium channel, neuropathic pain and trigeminal ganglion neurons
6) Confidence 0.45 Published 2005 Journal Pain Section Abstract Doc Link 16297558 Disease Relevance 0.89 Pain Relevance 0.66

General Comments

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