INT97376

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Context Info
Confidence 0.33
First Reported 2001
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 11
Total Number 12
Disease Relevance 6.79
Pain Relevance 8.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
IB4 6
sciatic nerve 1
spinal cord 1
neurons 1
DRG 1
RT1-M4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Pain 33 100.00 Very High Very High Very High
Calcitonin gene-related peptide 31 100.00 Very High Very High Very High
nMDA receptor 5 100.00 Very High Very High Very High
Adelta 2 100.00 Very High Very High Very High
Spinal cord 20 99.90 Very High Very High Very High
Sciatic nerve 26 99.52 Very High Very High Very High
c fibre 8 99.04 Very High Very High Very High
electroacupuncture 7 99.02 Very High Very High Very High
dorsal root ganglion 13 98.76 Very High Very High Very High
nociceptor 14 98.72 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nociception 33 100.00 Very High Very High Very High
Pain 31 100.00 Very High Very High Very High
Hypersensitivity 5 99.16 Very High Very High Very High
Injury 25 98.96 Very High Very High Very High
Ganglion Cysts 16 98.76 Very High Very High Very High
Nervous System Injury 36 97.88 Very High Very High Very High
Hyperalgesia 28 97.20 Very High Very High Very High
Inflammatory Pain 7 97.14 Very High Very High Very High
Neuropathic Pain 27 96.20 Very High Very High Very High
Gliosis 2 95.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Immunocytochemical detection of calcitonin gene-related peptide (CGRP) and isolectin B4 (IB4) binding was used to visualize the dorsal horn distribution of the boutons from the peptidergic and non-peptidergic fibers respectively.
Gene_expression (detection) of IB4 in dorsal horn associated with dorsal horn and calcitonin gene-related peptide
1) Confidence 0.33 Published 2006 Journal Neuroscience Section Abstract Doc Link 16413131 Disease Relevance 0.91 Pain Relevance 0.81
First, we injected isolectin B4 (IB4), into the sciatic nerves in three groups of rats, each of which had two of the three L4, L5, or L6 components ligated and cut, and the one remaining, uninjured.
Gene_expression (injected) of IB4 in IB4 associated with sciatic nerve
2) Confidence 0.11 Published 2009 Journal J. Comp. Neurol. Section Abstract Doc Link 19790268 Disease Relevance 0.38 Pain Relevance 0.44
In the present study, using a rat model of inflammatory pain induced by complete Freund's adjuvant (CFA), we observed the effect of electroacupuncture (EA) on animal behavior with regard to pain and the expression of a subunit of NMDA receptor (NR1) and isolectin B4 (IB4) in the neurons of the lumbar DRG.
Gene_expression (expression) of IB4 in IB4 associated with dorsal root ganglion, pain, nmda receptor, ipn and electroacupuncture
3) Confidence 0.08 Published 2006 Journal Brain Res. Section Abstract Doc Link 17005164 Disease Relevance 0.95 Pain Relevance 1.41
We evaluated on lumbar spinal cord the expression of microglial (ED-1), astrocytic (GFAP and S-100beta), and C- and Adelta-fibers (SubP, IB-4 and Cb) markers.
Gene_expression (expression) of IB-4 in spinal cord associated with adelta and spinal cord
4) Confidence 0.05 Published 2010 Journal Cell. Mol. Neurobiol. Section Abstract Doc Link 19585233 Disease Relevance 0.87 Pain Relevance 1.00
At E17, almost all Na(v)1.8-expressing neurons also express the high-affinity NGF receptor TrkA, and only a small proportion bind to IB4, a marker for c-ret-expressing (glial-derived neurotrophic factor-responsive) neurons.
Gene_expression (expressing) of IB4 in neurons
5) Confidence 0.05 Published 2001 Journal J. Neurosci. Section Abstract Doc Link 11487631 Disease Relevance 0 Pain Relevance 0.75
In our experiments over 50% of the cells that upregulated MCP-1 also expressed IB-4, which is a marker for C-fiber nociceptors that are responsible for transmitting pain information.
Gene_expression (expressed) of IB-4 in nociceptors associated with pain, c fibre and nociceptor
6) Confidence 0.03 Published 2007 Journal Mol Pain Section Body Doc Link PMC2228278 Disease Relevance 0.79 Pain Relevance 1.14
A proportion of the CB1 receptor-like immunopositive neurones was immunostained for CGRP (31.7+/-5%) and IB4 (48.2%+/-7.5), with a minimal (1%) co-expression of CGRP and IB4 binding.
Gene_expression (expression) of IB4 in IB4 associated with calcitonin gene-related peptide
7) Confidence 0.02 Published 2002 Journal Neuroscience Section Abstract Doc Link 11934481 Disease Relevance 0.36 Pain Relevance 0.48
Furthermore, we investigated the expression of various pain-related molecules such as calcitonin gene-related peptide (CGRP), isolectin B4 (IB4), P2X(3) receptor and vanniloid receptor 1 (VR1) in DRG neurons innervating the disc using a combination of immunostaining with the retrograde tracing method.
Spec (investigated) Gene_expression (expression) of IB4 in DRG associated with dorsal root ganglion, pain and calcitonin gene-related peptide
8) Confidence 0.02 Published 2004 Journal Life Sci. Section Abstract Doc Link 15041445 Disease Relevance 0.78 Pain Relevance 0.63
Following sciatic nerve injury in adult rats and treatment with BRX-220, the following features of the sensory system were studied: (a) expression of calcitonin gene-related peptide (CGRP); (b) binding of isolectin B4 (IB4) in dorsal root ganglia (DRG) and spinal cord; (c) stimulation-evoked release of substance P (SP) in an in vitro spinal cord preparation and (d) nociceptive responses of partially denervated rats.
Gene_expression (expression) of IB4 in sciatic nerve associated with nociception, nervous system injury, sciatic nerve, substance p, spinal cord and calcitonin gene-related peptide
9) Confidence 0.02 Published 2003 Journal Exp. Neurol. Section Abstract Doc Link 14769355 Disease Relevance 0.62 Pain Relevance 0.49
A proportion of the CB1 receptor-like immunopositive neurones was immunostained for CGRP (31.7+/-5%) and IB4 (48.2%+/-7.5), with a minimal (1%) co-expression of CGRP and IB4 binding.
Gene_expression (expression) of IB4 in IB4 associated with calcitonin gene-related peptide
10) Confidence 0.02 Published 2002 Journal Neuroscience Section Abstract Doc Link 11934481 Disease Relevance 0.37 Pain Relevance 0.48
In vehicle-treated rats there is a decrease in IB4 binding and CGRP expression in injured neurones, while in BRX-220-treated rats these markers were better preserved.
Gene_expression (expression) of IB4 in IB4 associated with calcitonin gene-related peptide
11) Confidence 0.01 Published 2003 Journal Exp. Neurol. Section Abstract Doc Link 14769355 Disease Relevance 0.55 Pain Relevance 0.54
On the other hand, the proportions of the co-expression of TRPM8 and nociceptive markers such as calcitonin gene-related peptide (CGRP), transient receptor potential vanilloid-1 (TRPV1), and isolectin B4 (IB4) in the bladder afferent neurons (81.5+/-5.2% for CGRP, 36.1+/-4.0% for TRPV1, and 15.8+/-5.5% for IB4) were higher in comparison to those in the total population of the TRPM8-immunoreactive afferent neurons (21.9+/-2.4% for CGRP, 16.6+/-1.7% for TRPV1, and 5.4+/-0.5% for IB4), although no significant difference existed for IB4.
Gene_expression (co-expression) of IB4 in IB4 associated with nociception and calcitonin gene-related peptide
12) Confidence 0.01 Published 2009 Journal Neurosci. Res. Section Abstract Doc Link 19622375 Disease Relevance 0.17 Pain Relevance 0.33

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