INT97381

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Context Info
Confidence 0.59
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 34
Total Number 34
Disease Relevance 16.66
Pain Relevance 11.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Nos2) signal transduction (Nos2) extracellular space (Nos2)
oxidoreductase activity (Nos2) peroxisome (Nos2) nucleus (Nos2)
Anatomy Link Frequency
macrophages 8
artery 4
paw 4
endothelial cells 2
RAW 264 2
Nos2 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 198 100.00 Very High Very High Very High
Paracetamol 19 100.00 Very High Very High Very High
Inflammatory response 17 100.00 Very High Very High Very High
Thermal hyperalgesia 5 99.82 Very High Very High Very High
Morphine 42 99.80 Very High Very High Very High
lidocaine 10 99.70 Very High Very High Very High
agonist 72 99.24 Very High Very High Very High
tolerance 10 99.12 Very High Very High Very High
Inflammation 193 98.88 Very High Very High Very High
Pain 24 98.88 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 226 100.00 Very High Very High Very High
Apoptosis 54 100.00 Very High Very High Very High
Targeted Disruption 38 100.00 Very High Very High Very High
Cancer 27 100.00 Very High Very High Very High
Necrosis 25 100.00 Very High Very High Very High
Repression 2 100.00 Very High Very High Very High
Hyperalgesia 5 99.82 Very High Very High Very High
Injury 23 99.80 Very High Very High Very High
Shock 6 99.40 Very High Very High Very High
Cold Sores 428 98.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Additionally, it suppressed induction of inducible nitric oxide synthase (iNOS) in the activated macrophages.
Negative_regulation (suppressed) of Positive_regulation (induction) of iNOS in macrophages
1) Confidence 0.59 Published 2008 Journal J Ethnopharmacol Section Abstract Doc Link 18164565 Disease Relevance 0.46 Pain Relevance 0.12
Treatment of macrophages with SBT leaf extract also caused a significant inhibition of iNOS activation.
Negative_regulation (inhibition) of Positive_regulation (activation) of iNOS in leaf
2) Confidence 0.59 Published 2006 Journal Int. Immunopharmacol. Section Abstract Doc Link 16332512 Disease Relevance 0.42 Pain Relevance 0.29
Additionally, it suppressed induction of inducible nitric oxide synthase (iNOS) in the activated macrophages.
Negative_regulation (suppressed) of Positive_regulation (induction) of inducible nitric oxide synthase in macrophages
3) Confidence 0.43 Published 2008 Journal J Ethnopharmacol Section Abstract Doc Link 18164565 Disease Relevance 0.46 Pain Relevance 0.12
Intact carrageenan-induced thermal hyperalgesia in mice lacking inducible nitric oxide synthase.
Negative_regulation (lacking) of Positive_regulation (inducible) of inducible nitric oxide synthase associated with inflammation and thermal hyperalgesia
4) Confidence 0.43 Published 2003 Journal Neuroscience Section Title Doc Link 12895524 Disease Relevance 0.63 Pain Relevance 0.82
The effect of aminoguanidine, an inducible nitric oxide synthase (iNOS) inhibitor, on morphine-induced tolerance and dependence in mice was investigated in this study.
Negative_regulation (inhibitor) of Positive_regulation (inducible) of inducible nitric oxide synthase associated with addiction, tolerance and morphine
5) Confidence 0.42 Published 2006 Journal Eur. J. Pharmacol. Section Abstract Doc Link 16730698 Disease Relevance 0.07 Pain Relevance 0.91
The effect of aminoguanidine, an inducible nitric oxide synthase (iNOS) inhibitor, on morphine-induced tolerance and dependence in mice was investigated in this study.
Negative_regulation (inhibitor) of Positive_regulation (inducible) of iNOS associated with addiction, tolerance and morphine
6) Confidence 0.42 Published 2006 Journal Eur. J. Pharmacol. Section Abstract Doc Link 16730698 Disease Relevance 0.07 Pain Relevance 0.91
Aminoguanidine (50, 100 mg/kg), the specific inducible nitric oxide synthase (iNOS) inhibitor, whether alone or in combination with cyclosporin A failed to show this inhibitory effect on morphine-induced place preference.
Negative_regulation (inhibitor) of Positive_regulation (inducible) of iNOS associated with morphine
7) Confidence 0.42 Published 2005 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15659300 Disease Relevance 0 Pain Relevance 0.79
In a rat splanchnic artery occlusion shock model, treatment with rHuEPO inhibited iNOS (inducible nitric-oxide synthase) activation with restoration of responsiveness to phenylephrine [30,31].
Negative_regulation (inhibited) of Positive_regulation (activation) of inducible nitric-oxide synthase in artery associated with shock
8) Confidence 0.41 Published 2007 Journal Crit Care Section Body Doc Link PMC2206412 Disease Relevance 0.75 Pain Relevance 0.04
As anticipated from previously described qPCR results, iNOS mRNA levels, which were induced by cytokine stimulation, were reduced 4.7-fold by coincubation with compound 1 (but unaffected by compound 2 treatment).
Negative_regulation (reduced) of Positive_regulation (induced) of iNOS associated with cytokine
9) Confidence 0.41 Published 2008 Journal Current Chemical Genomics Section Body Doc Link PMC2803434 Disease Relevance 0.17 Pain Relevance 0.48
In a dose-dependent manner, lidocaine significantly attenuated the LPS-induced upregulation of iNOS and CAT-2.
Negative_regulation (attenuated) of Positive_regulation (upregulation) of iNOS associated with lidocaine
10) Confidence 0.41 Published 2006 Journal Anesth. Analg. Section Abstract Doc Link 16717319 Disease Relevance 0 Pain Relevance 1.15
In inducible nitric oxide synthase (iNOS) knockout mice, nitration is prevented, but unscavenged superoxide production then causes toxic lipid peroxidation to occur instead.
Negative_regulation (prevented) of Positive_regulation (inducible) of inducible nitric oxide synthase associated with targeted disruption
11) Confidence 0.41 Published 2002 Journal Toxicol. Sci. Section Abstract Doc Link 11812920 Disease Relevance 1.47 Pain Relevance 0.21
Glutathione depletion by DEM or APAP was associated with inhibition of TNF-induced NF-kappaB transactivation of anti-apoptotic genes, including inducible nitric oxide synthase (i-NOS).
Negative_regulation (inhibition) of Positive_regulation (transactivation) of inducible nitric oxide synthase associated with paracetamol and apoptosis
12) Confidence 0.38 Published 2003 Journal Hepatology Section Abstract Doc Link 12774022 Disease Relevance 0.88 Pain Relevance 0.34
These results suggested a therapeutic value of Neurotropin in the treatment of endotoxin shock that was linked, at least in part, to suppression of iNOS induction and reduced cell damage in vascular endothelial cells.
Negative_regulation (suppression) of Positive_regulation (induction) of iNOS in endothelial cells associated with shock
13) Confidence 0.38 Published 2001 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 11488434 Disease Relevance 0.40 Pain Relevance 0.06
Simultaneous treatment of the cells with Neurotropin resulted in complete suppression of iNOS induction and significant reduction of cell death.
Negative_regulation (suppression) of Positive_regulation (induction) of iNOS associated with death
14) Confidence 0.38 Published 2001 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 11488434 Disease Relevance 0.32 Pain Relevance 0.07
Sigma 1 receptor agonists act as neuroprotective drugs through inhibition of inducible nitric oxide synthase.
Negative_regulation (inhibition) of Positive_regulation (inducible) of inducible nitric oxide synthase associated with fortral and agonist
15) Confidence 0.37 Published 2006 Journal Anesth. Analg. Section Title Doc Link 16861428 Disease Relevance 0.39 Pain Relevance 0.34
Aminoguanidine (50, 100 mg/kg), the specific inducible nitric oxide synthase (iNOS) inhibitor, whether alone or in combination with cyclosporin A failed to show this inhibitory effect on morphine-induced place preference.
Negative_regulation (inhibitor) of Positive_regulation (inducible) of inducible nitric oxide synthase associated with morphine
16) Confidence 0.37 Published 2005 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15659300 Disease Relevance 0 Pain Relevance 0.79
Western blotting revealed that ST1 (10 mg/kg) decreased Carr-induced inducible nitric oxide synthase (iNOS), and cycloxyclase (COX-2) expressions at 5 h in the edema paw.
Negative_regulation (decreased) of Positive_regulation (induced) of inducible nitric oxide synthase in paw associated with pressure and volume under development
17) Confidence 0.36 Published 2010 Journal J. Agric. Food Chem. Section Abstract Doc Link 20507140 Disease Relevance 0.99 Pain Relevance 0.39
Western blotting revealed that ST1 (10 mg/kg) decreased Carr-induced inducible nitric oxide synthase (iNOS), and cycloxyclase (COX-2) expressions at 5 h in the edema paw.
Negative_regulation (decreased) of Positive_regulation (induced) of iNOS in paw associated with pressure and volume under development
18) Confidence 0.36 Published 2010 Journal J. Agric. Food Chem. Section Abstract Doc Link 20507140 Disease Relevance 0.99 Pain Relevance 0.39
Carprofen and flunixin meglumine, but not phenylbutazone, inhibited LPS-induction of iNOS.
Negative_regulation (inhibited) of Positive_regulation (induction) of iNOS
19) Confidence 0.36 Published 2003 Journal Am. J. Vet. Res. Section Body Doc Link 12602591 Disease Relevance 0 Pain Relevance 0
In inducible nitric oxide synthase (iNOS) knockout mice, nitration is prevented, but unscavenged superoxide production then causes toxic lipid peroxidation to occur instead.
Negative_regulation (prevented) of Positive_regulation (inducible) of iNOS associated with targeted disruption
20) Confidence 0.35 Published 2002 Journal Toxicol. Sci. Section Abstract Doc Link 11812920 Disease Relevance 1.47 Pain Relevance 0.21

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