INT97383

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Context Info
Confidence 0.08
First Reported 2001
Last Reported 2005
Negated 0
Speculated 0
Reported most in Title
Documents 2
Total Number 2
Disease Relevance 1.53
Pain Relevance 1.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (NOSTRIN) cytoplasmic membrane-bounded vesicle (NOSTRIN) plasma membrane (NOSTRIN)
cytoskeleton (NOSTRIN) cytoplasm (NOSTRIN)
Anatomy Link Frequency
bowel 2
NOSTRIN (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 6 97.62 Very High Very High Very High
spastic colon 8 96.30 Very High Very High Very High
Analgesic 1 94.72 High High
corticosteroid 3 93.28 High High
COX2 3 90.32 High High
substance P 1 87.96 High High
COX-2 inhibitor 1 79.04 Quite High
biopsychosocial 1 76.00 Quite High
Bioavailability 1 36.32 Quite Low
cytokine 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Pressure Volume 2 Under Development 1 99.20 Very High Very High Very High
INFLAMMATION 6 97.62 Very High Very High Very High
Pox Virus Infection 1 96.72 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

6 96.30 Very High Very High Very High
Shock 2 90.08 High High
Parasitic Infection 1 86.08 High High
Functional Bowel Disorder 2 75.00 Quite High
Diarrhoea 2 75.00 Quite High
Gastrointestinal Disease 1 72.08 Quite High
Infection 1 71.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In IBS patients, increased cellularity and proximity of the inflammatory or immune cells to the nerve trunks of the bowel, elevated interleukin-1beta mRNA expression in mucosal biopsies, and increased inducible nitric oxide synthase and nitrotyrosine elaboration (indicative of lymphocyte activation) were observed.
Positive_regulation (increased) of Positive_regulation (inducible) of nitric oxide synthase in bowel associated with inflammation and spastic colon
1) Confidence 0.08 Published 2005 Journal Med. Hypotheses Section Abstract Doc Link 15893125 Disease Relevance 0.82 Pain Relevance 0.95
Protective effect of neurotropin against lipopolysaccharide-induced hypotension and lethality linked to suppression of inducible nitric oxide synthase induction.
Positive_regulation (inducible) of Positive_regulation (induction) of nitric oxide synthase associated with pressure volume 2 under development
2) Confidence 0.04 Published 2001 Journal Jpn. J. Pharmacol. Section Title Doc Link 11488434 Disease Relevance 0.35 Pain Relevance 0.09

General Comments

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