INT97391

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Context Info
Confidence 0.48
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 18
Total Number 18
Disease Relevance 8.97
Pain Relevance 4.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Lep) extracellular region (Lep) intracellular (Lep)
lipid metabolic process (Lep)
Anatomy Link Frequency
body 3
brain 1
autonomic 1
hypothalamus 1
fat 1
Lep (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Cholecystokinin 19 100.00 Very High Very High Very High
Central nervous system 7 100.00 Very High Very High Very High
Opioid 10 99.16 Very High Very High Very High
mu opioid receptor 5 98.88 Very High Very High Very High
antagonist 10 97.48 Very High Very High Very High
Neuropeptide 4 97.12 Very High Very High Very High
antidepressant 47 96.36 Very High Very High Very High
rheumatoid arthritis 64 96.16 Very High Very High Very High
qutenza 8 95.96 Very High Very High Very High
fluoxetine 21 94.84 High High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 5 99.94 Very High Very High Very High
Stress 13 99.76 Very High Very High Very High
Obesity 216 99.44 Very High Very High Very High
Body Weight 60 99.12 Very High Very High Very High
Wound Healing 4 99.04 Very High Very High Very High
Pancreatitis 14 97.60 Very High Very High Very High
Appetite Loss 28 97.56 Very High Very High Very High
Rheumatoid Arthritis 69 96.16 Very High Very High Very High
Disease 43 94.64 High High
INFLAMMATION 83 93.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Leptin may interact with stress hormones and with the brain serotonergic system, possibly affecting the feeding behavior of stressed rats.
Leptin Binding (interact) of in brain associated with stress
1) Confidence 0.48 Published 2008 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 18423829 Disease Relevance 0.56 Pain Relevance 0.53
However, interactions between leptin and the activity of peripheral opioids on body weight and fat accumulation have not been investigated.
leptin Binding (interactions) of in fat associated with body weight and opioid
2) Confidence 0.48 Published 2009 Journal J Opioid Manag Section Abstract Doc Link 20073411 Disease Relevance 0.46 Pain Relevance 0.64
Vagal afferent neurons also express receptors for both CCK and leptin, which are believed to interact in controlling food intake.
leptin Binding (interact) of in afferent neurons
3) Confidence 0.48 Published 2007 Journal Physiol Res Section Abstract Doc Link 16792473 Disease Relevance 0.15 Pain Relevance 0.09
Receptors for leptin are expressed throughout the body and leptin binding to these receptors has been shown to stimulate adaptive as well as innate immune response as reviewed elsewhere [9, 13, 14].
leptin Binding (binding) of in body
4) Confidence 0.45 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2817554 Disease Relevance 0.76 Pain Relevance 0
These studies suggest that HF feeding is associated with increased body fat, plasma leptin, insulin, and hypothalamic mu opioid receptors.
plasma leptin Binding (associated) of in body associated with mu opioid receptor
5) Confidence 0.41 Published 2003 Journal Brain Res. Bull. Section Abstract Doc Link 13679250 Disease Relevance 0.21 Pain Relevance 0.39
These results indicate the existence of a functional interaction between leptin and CCK receptors leading to inhibition of gastric emptying and short-term suppression of food intake, providing an additional feedback control in producing satiety.
leptin Binding (interaction) of
6) Confidence 0.37 Published 2007 Journal Physiol Res Section Abstract Doc Link 16792473 Disease Relevance 0.13 Pain Relevance 0.04
Leptin and cholecystokinin (CCK) have a synergistic interaction in the suppression of food intake, and afford similar gastroprotective activity.
Leptin Binding (interaction) of associated with cholecystokinin
7) Confidence 0.37 Published 2003 Journal Regul. Pept. Section Abstract Doc Link 14599722 Disease Relevance 0.31 Pain Relevance 0.60
Leptin acts in the central nervous system through binding to leptin receptors located in the hypothalamus, particularly in the arcuate nucleus and by coordinating metabolism, feeding behavior, energy balance and neuroendocrine responses [7-9].
Leptin Binding (binding) of in hypothalamus associated with central nervous system
8) Confidence 0.36 Published 2008 Journal BMC Complement Altern Med Section Body Doc Link PMC2263016 Disease Relevance 0.82 Pain Relevance 0.16
In all these areas (except the MPA), binding was significantly correlated with plasma leptin and insulin.
leptin Binding (binding) of in MPA associated with urological neuroanatomy
9) Confidence 0.35 Published 2002 Journal Brain Res. Section Abstract Doc Link 12384255 Disease Relevance 0.68 Pain Relevance 0.35
Because the peak effect of leptin was observed at a concentration of 62?
leptin Binding (concentration) of
10) Confidence 0.35 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2817554 Disease Relevance 0.44 Pain Relevance 0.11
mg/kg) intravenous leptin administration on leukocyte-endothelial cell interactions in the rat mesenteric microvasculature.
leptin Binding (interactions) of in leukocyte
11) Confidence 0.35 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2817554 Disease Relevance 0.92 Pain Relevance 0.12
Recent studies have shown a synergistic interaction between leptin and cholecystokinin (CCK) leading to suppression of food intake, which involves CCK-1 receptors and capsaicin-sensitive vagal fibres.
leptin Binding (interaction) of associated with qutenza and cholecystokinin
12) Confidence 0.34 Published 2001 Journal Eur. J. Neurosci. Section Abstract Doc Link 11488950 Disease Relevance 0.23 Pain Relevance 0.37
Similar protective effects were observed following i.c.v. application of leptin (0.4 or 2 microg/rat) but not melatonin (10 or 40 microg/rat) to the CIP rats.
leptin Binding (application) of associated with pancreatitis
13) Confidence 0.32 Published 2002 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 11939719 Disease Relevance 0.73 Pain Relevance 0.35
Of interest, differences between genders concerning the sensitivity to central leptin and insulin have been previously described [28,29].
leptin Binding (sensitivity) of
14) Confidence 0.31 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2939651 Disease Relevance 0.06 Pain Relevance 0
Treatment with leptin (10?
leptin Binding (Treatment) of
15) Confidence 0.24 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2585815 Disease Relevance 0.09 Pain Relevance 0
Specifically, leptin binds to the ventromedial nucleus of the hypothalamus, which sends a signal to the brain indicating that the body has had enough to eat [24].
leptin Binding (binds) of in body
16) Confidence 0.19 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC3009642 Disease Relevance 0.87 Pain Relevance 0.07
Additionally, to our knowledge, this is the first report of cue-elicited activation of the arcuate nucleus of the hypothalamus, where direct energy-balance signals from the periphery (e.g. leptin and ghrelin) are integrated with motor and autonomic effector systems [3,91].
leptin Binding (integrated) of in autonomic
17) Confidence 0.13 Published 2007 Journal BMC Biol Section Body Doc Link PMC1868707 Disease Relevance 0 Pain Relevance 0.13
Some processes intrinsic to the pathogenesis of RA play important roles in CV damage and its clinical consequences: abnormal endothelial function [32], autoantibodies against oxidized low-density lipoprotein [33], and levels of serum mannose-binding leptin [34].
leptin Binding (binding) of associated with rheumatoid arthritis
18) Confidence 0.01 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2453774 Disease Relevance 1.56 Pain Relevance 0.51

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