INT97392

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Context Info
Confidence 0.65
First Reported 2001
Last Reported 2011
Negated 0
Speculated 1
Reported most in Body
Documents 27
Total Number 32
Disease Relevance 14.21
Pain Relevance 4.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Stat3) nucleolus (Stat3) plasma membrane (Stat3)
nucleus (Stat3) DNA binding (Stat3) transcription factor binding (Stat3)
Anatomy Link Frequency
brain 4
hypothalamus 2
myocardium 1
dorsal 1
retina 1
Stat3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
fibrosis 18 99.48 Very High Very High Very High
Sciatic nerve 10 99.36 Very High Very High Very High
qutenza 22 98.76 Very High Very High Very High
cytokine 101 98.36 Very High Very High Very High
Inflammation 293 97.96 Very High Very High Very High
vagus nerve 12 96.36 Very High Very High Very High
Nerve growth factor 16 87.48 High High
ischemia 134 84.40 Quite High
Cholecystokinin 8 77.60 Quite High
anesthesia 28 73.20 Quite High
Disease Link Frequency Relevance Heat
Death 142 99.68 Very High Very High Very High
Apoptosis 310 99.64 Very High Very High Very High
Fibrosis 24 99.48 Very High Very High Very High
Ganglion Cysts 22 98.88 Very High Very High Very High
Aids-related Complex 178 98.76 Very High Very High Very High
Eating Disorder 2 98.60 Very High Very High Very High
INFLAMMATION 421 97.96 Very High Very High Very High
Diabetes Mellitus 199 96.48 Very High Very High Very High
Appetite Loss 22 95.08 Very High Very High Very High
Diabetic Retinopathy 34 94.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Posphorylated STAT3, which was almost non-detectable in the control sciatic nerve, clearly peaked at 6 h after the capsaicin treatment and decreased again during the following days to almost undetectable levels.
Gene_expression (non-detectable) of STAT3 in sciatic nerve associated with qutenza and sciatic nerve
1) Confidence 0.65 Published 2005 Journal Pharmacology Section Abstract Doc Link 16141720 Disease Relevance 0.06 Pain Relevance 1.04
Western blots were probed with polyclonal antibodies that specifically detect phosphorylated ERK 1/2 and STAT3.
Gene_expression (detect) of STAT3
2) Confidence 0.65 Published 2005 Journal Pharmacology Section Abstract Doc Link 16141720 Disease Relevance 0.08 Pain Relevance 0.62
Insulin treatment partially normalized the protein expression of Cp, Lgals3, and Stat3 with the insulin-treated group no longer significantly elevated from control but also not significantly lower than the diabetic group (Figure 7).
Gene_expression (expression) of Stat3 associated with diabetes mellitus
3) Confidence 0.64 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020973 Disease Relevance 0.32 Pain Relevance 0
As such, modulation of Stat3 expression likely impacts a variety of pathways and processes in the retina and may prove to be a useful target in drug development efforts for diabetic retinopathy.
Gene_expression (expression) of Stat3 in retina associated with diabetic retinopathy
4) Confidence 0.64 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020973 Disease Relevance 0.51 Pain Relevance 0.04
Immunohistochemistry showed the presence of leptin receptors and the leptin-induced transcription factor STAT3 in the cytoplasm of nodose ganglion cells.
Gene_expression (presence) of STAT3 in ganglion cells associated with ganglion cysts
5) Confidence 0.61 Published 2001 Journal Eur. J. Neurosci. Section Abstract Doc Link 11488950 Disease Relevance 0.43 Pain Relevance 0.40
In addition, leptin receptor and STAT3 immunoreactivities were detected in neurons of the nucleus of tractus solitarius (NTS) and the dorsal motor nucleus of the vagus nerve (DMNX) by immunofluorescence histochemistry.
Gene_expression (detected) of STAT3 in dorsal associated with vagus nerve
6) Confidence 0.55 Published 2001 Journal Eur. J. Neurosci. Section Abstract Doc Link 11488950 Disease Relevance 0.39 Pain Relevance 0.42
The increase in Stat3 expression associated with overexpression of Fto and reduced food intake is consistent with its potential role in mediating leptin's anorectic effects.
Gene_expression (expression) of Stat3 associated with appetite loss
7) Confidence 0.54 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808248 Disease Relevance 0.68 Pain Relevance 0
We analyzed the changes in neurological severity scores, infarct volume, number of apoptotic neurons, and the expression of G-CSF receptor, phosphorylated signal transducer and activator of transcription 3 (pSTAT3), cellular inhibitor of apoptosis protein 2 (cIAP2), Bcl-2, and Bax in the brain tissue.
Gene_expression (expression) of pSTAT3 in brain associated with apoptosis
8) Confidence 0.46 Published 2008 Journal Tohoku J. Exp. Med. Section Abstract Doc Link 18832793 Disease Relevance 1.87 Pain Relevance 0.16
Levels of Cx43 (connexin 43), STAT3 (signal transducer and activator of transcription 3), and Sirt 1 (sirtuin), which play a role in cardioprotection, are also decreased.
Gene_expression (Levels) of STAT3
9) Confidence 0.45 Published 2010 Journal Korean Journal of Anesthesiology Section Body Doc Link PMC2872846 Disease Relevance 0.52 Pain Relevance 0.03
Fasting induced decrease in p53 acetylation [10] was also reversed by inhibition of Sirt1 function, and Stat3 acetylation was insensitive to Sirt1 inhibition (data not shown).
Gene_expression (acetylation) of Stat3
10) Confidence 0.44 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2790615 Disease Relevance 0.16 Pain Relevance 0
Therefore we analyzed whether FoxO1 or Stat3 acetylation was nutrient sensitive in the ARC.
Spec (whether) Gene_expression (acetylation) of Stat3 associated with aids-related complex
11) Confidence 0.44 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2790615 Disease Relevance 0.23 Pain Relevance 0
Figure 4A shows that whereas Stat3 acetylation did not change upon fasting, there was a significant decrease in FoxO1 acetylation.
Gene_expression (acetylation) of Stat3
12) Confidence 0.44 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2790615 Disease Relevance 0.24 Pain Relevance 0
Under our experimental conditions we could not detect any significant change in the acetylation of ARC Stat3 by fasting, inhibition of Sirt1, or leptin administration, working against the hypothesis that Sirt1 targets Stat3 in the hypothalamus.
Gene_expression (targets) of Stat3 in hypothalamus associated with aids-related complex
13) Confidence 0.44 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2790615 Disease Relevance 0.25 Pain Relevance 0
This discrepancy could have been due to the fact that the PCR conditions for Stat3 were not optimal (only half of the reactions yielded Cp values) and/or the expression level of Stat3 was so low that it was not detected in some of our samples.
Gene_expression (expression) of Stat3
14) Confidence 0.42 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2894843 Disease Relevance 0.20 Pain Relevance 0
Only at one point in our validation comparisons did we find a discrepancy in the PCR and microarray data, and that was the expression of Stat3 at 2-weeks post axotomy.
Gene_expression (expression) of Stat3
15) Confidence 0.42 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2894843 Disease Relevance 0.05 Pain Relevance 0
However, a 4-fold increase in the expression of the transcription factor Stat3, and a 5- fold reduction in Tyrosine Hydroxylase, was observed with Fto over expression in the ARC, suggest possible candidates for the mediation of Fto's action.


Gene_expression (expression) of Stat3 associated with aids-related complex
16) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808248 Disease Relevance 0.53 Pain Relevance 0
Another important observation from this study is that intact STAT-3 signaling in the hypothalamus is necessary for the effects of HN on glucose metabolism.
Gene_expression (necessary) of STAT-3 in hypothalamus
17) Confidence 0.42 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2709436 Disease Relevance 0.50 Pain Relevance 0.03
We analyzed the changes in neurological severity scores, infarct volume, number of apoptotic neurons, and the expression of G-CSF receptor, phosphorylated signal transducer and activator of transcription 3 (pSTAT3), cellular inhibitor of apoptosis protein 2 (cIAP2), Bcl-2, and Bax in the brain tissue.
Gene_expression (expression) of phosphorylated signal transducer and activator of transcription 3 in brain associated with apoptosis
18) Confidence 0.40 Published 2008 Journal Tohoku J. Exp. Med. Section Abstract Doc Link 18832793 Disease Relevance 1.87 Pain Relevance 0.11
Four of these genes (Actb, Fgf9, Gfra1, Hspb1) demonstrated both a significant change in expression and a correlated expression trend in both arrays, while the remaining 5 genes (Gfra2, Ngfrap1, Npy, Lifr, Stat3) showed a significant change in expression in either the PCR array or microarray but still demonstrated a correlated mean relative expression trend.
Gene_expression (expression) of Stat3
19) Confidence 0.36 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2894843 Disease Relevance 0 Pain Relevance 0
This discrepancy could have been due to the fact that the PCR conditions for Stat3 were not optimal (only half of the reactions yielded Cp values) and/or the expression level of Stat3 was so low that it was not detected in some of our samples.
Gene_expression (expression) of Stat3
20) Confidence 0.36 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2894843 Disease Relevance 0.19 Pain Relevance 0

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