INT97394

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Context Info
Confidence 0.41
First Reported 2001
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 2.52
Pain Relevance 1.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Stat3) nucleolus (Stat3) plasma membrane (Stat3)
nucleus (Stat3) DNA binding (Stat3) transcription factor binding (Stat3)
Anatomy Link Frequency
dorsal 1
astrocyte 1
AtT20 1
Stat3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
vagus nerve 5 95.80 Very High Very High Very High
Inflammation 65 93.04 High High
cytokine 14 89.76 High High
Inflammatory marker 1 89.20 High High
glial activation 1 89.04 High High
Morphine 4 83.80 Quite High
Central nervous system 7 77.56 Quite High
Opioid 4 75.00 Quite High
ischemia 4 73.88 Quite High
chemokine 6 65.92 Quite High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 182 99.76 Very High Very High Very High
Eating Disorder 1 98.60 Very High Very High Very High
Epiretinal Membrane 1 98.60 Very High Very High Very High
Ganglion Cysts 9 97.04 Very High Very High Very High
INFLAMMATION 77 93.04 High High
Diabetic Retinopathy 66 76.64 Quite High
Rheumatoid Arthritis 1 75.20 Quite High
Insulin Resistance 1 74.88 Quite High
Cv Unclassified Under Development 3 73.88 Quite High
Aids-related Complex 22 67.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data suggest that OIC occurs via the JAK2 regulation of PI3K pathway-dependent STAT3, Akt, and GSK-3 beta, with GSK-3 beta contributing a central role in acute OIC.
Regulation (regulation) of STAT3
1) Confidence 0.41 Published 2006 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 16517948 Disease Relevance 0.13 Pain Relevance 0.41
The angiotensin converting enzyme inhibitor enalapril has been demonstrated to prevent the diabetes-induced up-regulation of Stat3 protein [58].
Regulation (regulation) of Stat3 associated with diabetes mellitus
2) Confidence 0.37 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020973 Disease Relevance 0.45 Pain Relevance 0.03
The induction of astrocyte activation is also reflected by an up-regulation of BMP-2, STAT3 and p300 which are factors in the BMP signalling pathway.
Regulation (regulation) of STAT3 in astrocyte
3) Confidence 0.32 Published 2010 Journal BMC Infect Dis Section Body Doc Link PMC2915993 Disease Relevance 0.29 Pain Relevance 0.24
TIMP-1 (tissue inhibitor of metallopeptidase1) expression is regulated through STAT3 [38] and TIMP-1 is induced in the epiretinal membranes of Type 1 and Type 2 diabetic patients [39].
Regulation (regulated) of STAT3 associated with epiretinal membrane and diabetes mellitus
4) Confidence 0.31 Published 2008 Journal BMC Med Genomics Section Body Doc Link PMC2442612 Disease Relevance 1.08 Pain Relevance 0.23
In addition, leptin receptor and STAT3 immunoreactivities were detected in neurons of the nucleus of tractus solitarius (NTS) and the dorsal motor nucleus of the vagus nerve (DMNX) by immunofluorescence histochemistry.
Regulation (immunoreactivities) of STAT3 in dorsal associated with vagus nerve
5) Confidence 0.25 Published 2001 Journal Eur. J. Neurosci. Section Abstract Doc Link 11488950 Disease Relevance 0.39 Pain Relevance 0.42
Two patterns of expression were evident with one set of proteins regulated at both the transcript and protein levels (Cp, Lgals3, Fgf2, and Stat3) (Figure 5) and another set with altered protein expression but no significant changes in transcript expression (Cryaa, Cryab, Cryba3, Crybb2, Dbi, and Anxa5) (Figure 6).
Regulation (regulated) of Stat3
6) Confidence 0.22 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020973 Disease Relevance 0 Pain Relevance 0
AtT20 cells express Sirt1 (Figure S1B), POMC, and several key transcription factors involved in POMC regulation such as Stat3 and FoxO1 (data not shown).
Regulation (regulation) of Stat3 in AtT20
7) Confidence 0.18 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2790615 Disease Relevance 0.18 Pain Relevance 0

General Comments

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