INT97398

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Context Info
Confidence 0.36
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 13
Disease Relevance 6.88
Pain Relevance 2.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (gr)
Anatomy Link Frequency
nucleus 4
HSF 1
PP2A 1
gr (Mus musculus)
Pain Link Frequency Relevance Heat
corticosteroid 6 99.30 Very High Very High Very High
dexamethasone 85 98.74 Very High Very High Very High
Spinal cord 23 98.32 Very High Very High Very High
Multiple sclerosis 2 98.24 Very High Very High Very High
cINOD 10 97.84 Very High Very High Very High
Inflammation 163 96.60 Very High Very High Very High
antidepressant 22 94.16 High High
fluoxetine 6 89.44 High High
cytokine 10 80.56 Quite High
chemokine 9 80.00 Quite High
Disease Link Frequency Relevance Heat
Shock 18 99.18 Very High Very High Very High
Chronic Obstructive Pulmonary Disease 216 98.74 Very High Very High Very High
Demyelinating Disease 8 98.24 Very High Very High Very High
INFLAMMATION 223 97.60 Very High Very High Very High
Asthma 34 97.56 Very High Very High Very High
Disease 81 97.10 Very High Very High Very High
Spasticity 35 96.16 Very High Very High Very High
Stress 60 93.36 High High
Pulmonary Disease 4 92.72 High High
Neurodegenerative Disease 3 89.04 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As our selection of candidate genes relied on a potential protective role, we screened genes based on their natural regulation in presence of an intact LPS and GR signaling.
Localization (presence) of GR
1) Confidence 0.36 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1819560 Disease Relevance 0.28 Pain Relevance 0.03
Pattern B, which was partially controlled by glucocorticoids, includes Fkbp5, a chaperone that inhibits GR translocation into the nucleus [88].
Localization (translocation) of GR in nucleus
2) Confidence 0.34 Published 2010 Journal Genome Biol Section Body Doc Link PMC2898085 Disease Relevance 0.31 Pain Relevance 0.16
GR for all subjects were well located below the diagonal line, indicating that GR was significantly lower Post as compared with Pre drug administration (p < 0.001).
Localization (located) of GR
3) Confidence 0.32 Published 2010 Journal J Neuroeng Rehabil Section Body Doc Link PMC2904341 Disease Relevance 0.10 Pain Relevance 0.08
In addition, was observed on failure day that GR as well as ?
Localization (well) of GR
4) Confidence 0.27 Published 2007 Journal Malar J Section Body Doc Link PMC1864988 Disease Relevance 0 Pain Relevance 0
They act by binding to a specific glucocorticoid receptor (GR) that on activation translocates to the nucleus and either increases (transactivates) or decreases (transrepresses) the expression of responsive genes.
Localization (translocates) of GR in nucleus
5) Confidence 0.11 Published 2001 Journal Immunol. Cell Biol. Section Abstract Doc Link 11488985 Disease Relevance 0.99 Pain Relevance 0.34
The ability of most patients to respond to dexamethasone with induction of histone acetylation correlated with nuclear translocation of GR.
Localization (translocation) of GR associated with dexamethasone
6) Confidence 0.11 Published 2001 Journal Immunol. Cell Biol. Section Abstract Doc Link 11488985 Disease Relevance 0.76 Pain Relevance 0.29
translocation contributes to reduced GC responsiveness in some diseases, such as in a subset of patients with multiple sclerosis where an elevation of expression of heat shock protein 90 (Hsp90) results in increased sequestration of GR?
Localization (sequestration) of GR associated with multiple sclerosis, shock and disease
7) Confidence 0.09 Published 2010 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2939685 Disease Relevance 1.09 Pain Relevance 0.11
in COPD and importantly, any functional impact by an elevation in the ration of GR?
Localization (ration) of GR associated with chronic obstructive pulmonary disease
8) Confidence 0.09 Published 2010 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2939685 Disease Relevance 1.03 Pain Relevance 0.15
They act by binding to the glucocorticoid receptor (GR) that, upon activation, translocates to the nucleus and either stimulates or inhibits gene expression.
Localization (translocates) of GR in nucleus
9) Confidence 0.09 Published 2004 Journal Mech. Ageing Dev. Section Abstract Doc Link 15541765 Disease Relevance 0.41 Pain Relevance 0.21
Corticosteroids act through a cytosolic receptor [GR (glucocorticoid receptor)], which is activated and translocates to the nucleus.
Localization (translocates) of GR in nucleus associated with corticosteroid
10) Confidence 0.08 Published 2009 Journal Biochem. Soc. Trans. Section Abstract Doc Link 19614602 Disease Relevance 0.67 Pain Relevance 0.32
Furthermore, the increased PP2A concentration may intensify GR action not only by inhibition of JNK and p38 phosphorylation, but also by a direct influence on the process of GR translocation.
Localization (translocation) of GR in PP2A
11) Confidence 0.04 Published 2010 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 20436222 Disease Relevance 0.38 Pain Relevance 0.20
However, prolonged treatment with dexamethasone suppresses the expression of HSP70, possibly due to the induction of MAPK and GR translocation.
Localization (translocation) of GR associated with dexamethasone
12) Confidence 0.03 Published 2010 Journal Psychiatry Investigation Section Body Doc Link PMC2848765 Disease Relevance 0.60 Pain Relevance 0.40
The level of HSP70 expression could be decreased by the negative feedback of inhibiting trimerization of HSF in the process of GR translocation.
Localization (translocation) of GR in HSF
13) Confidence 0.03 Published 2010 Journal Psychiatry Investigation Section Body Doc Link PMC2848765 Disease Relevance 0.26 Pain Relevance 0.30

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