INT97418

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Context Info
Confidence 0.41
First Reported 2001
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 0.94
Pain Relevance 1.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Nos1) aging (Nos1) enzyme binding (Nos1)
cytoplasm (Nos1) cytosol (Nos1) oxidoreductase activity (Nos1)
Anatomy Link Frequency
spinal cord 4
neurons 2
brain 2
Nos1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neuronal nitric oxide synthase 8 100.00 Very High Very High Very High
Dynorphin 7 99.42 Very High Very High Very High
Spinal cord 10 99.20 Very High Very High Very High
intrathecal 5 99.16 Very High Very High Very High
Hippocampus 6 99.08 Very High Very High Very High
long-term potentiation 10 98.68 Very High Very High Very High
Central nervous system 4 95.16 Very High Very High Very High
nMDA receptor 10 92.32 High High
Dorsal horn 1 90.32 High High
algogenic 2 76.44 Quite High
Disease Link Frequency Relevance Heat
Spinal Cord Injury 6 97.36 Very High Very High Very High
Injury 5 79.60 Quite High
Pressure And Volume Under Development 2 75.00 Quite High
Cognitive Disorder 4 5.00 Very Low Very Low Very Low
Endometriosis (extended) 2 5.00 Very Low Very Low Very Low
Peripheral Arterial Disease 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Importantly, we clarified the potential roles of PKCgamma in the regulation of nNOS and COX-2 following intrathecal injection with KA in the rat spinal cord.
Regulation (roles) of Regulation (regulation) of nNOS in spinal cord associated with spinal cord and intrathecal
1) Confidence 0.41 Published 2001 Journal Neurosci. Lett. Section Abstract Doc Link 11489538 Disease Relevance 0 Pain Relevance 0.53
Consequently, NO takes part in mechanisms of synaptic plasticity, including long-term potentiation (LTP) in the hippocampus.39 It has been widely reported that estrogen affects nNOS mRNA regulation, the number of nNOS-expressing neurons and NO production in the brain.16,17 Previous studies imply that estrogen in the central nervous system participates in increased nitric oxide production.10 It is believed that administration of l-arginine improves memory consolidation and learning,40 but the results of the present study show that chronic administration of l-arginine in combination with estradiol attenuated the estradiol-mediated improvement of learning in OVX rats.
Regulation (affects) of Regulation (regulation) of nNOS in neurons associated with central nervous system, hippocampus and long-term potentiation
2) Confidence 0.20 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2933129 Disease Relevance 0 Pain Relevance 0.24
However, the exact mechanism is still unknown.9 It has been well documented that estrogen influences the NO system in both peripheral and nervous tissues.10-12 Additionally, estrogen increases eNOS activity and expression13,14 as well as the production of nitric oxide in endothelial cells.15 Estrogen alters nNOS mRNA regulation, the number of nNOS-expressing neurons and NO production in the brain.16,17
Regulation (alters) of Regulation (regulation) of nNOS in brain
3) Confidence 0.20 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2933129 Disease Relevance 0 Pain Relevance 0.15
The present investigation was undertaken to find out whether topical application of dynorphin A (1-17) antiserum has some influence on neuronal NOS up-regulation in the traumatized spinal cord.
Spec (whether) Regulation (influence) of Regulation (regulation) of neuronal NOS in spinal cord associated with dynorphin, spinal cord and neuronal nitric oxide synthase
4) Confidence 0.12 Published 2006 Journal Acta Neurochir. Suppl. Section Abstract Doc Link 16671477 Disease Relevance 0.94 Pain Relevance 0.76

General Comments

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