INT97431

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Context Info
Confidence 0.44
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Title
Documents 5
Total Number 5
Disease Relevance 0.64
Pain Relevance 1.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Adam7) plasma membrane (Adam7)
Anatomy Link Frequency
blood 1
spikes 1
brain 1
Adam7 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Opioid 3 100.00 Very High Very High Very High
Pain 1 99.12 Very High Very High Very High
fluoxetine 1 97.00 Very High Very High Very High
Thalamus 3 94.60 High High
positron emission tomography 3 92.08 High High
imagery 14 90.48 High High
Action potential 33 90.12 High High
Serotonin 2 75.00 Quite High
pruritus 1 58.88 Quite High
sodium channel 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Skin Cancer 6 96.72 Very High Very High Very High
Cancer 2 94.04 High High
Ecchymosis 1 59.36 Quite High
Pruritus 1 58.88 Quite High
Disease 3 45.44 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The LVV-hemorphin-7 infusion to the venous blood produced the C-terminal fragments 2-10, 3-10, 4-10, and 5-10, N-terminal fragment 1-9, and internal fragments 4-7 and 4-9.
Gene_expression (produced) of LVV-hemorphin-7 in blood
1) Confidence 0.44 Published 2003 Journal Rapid Commun. Mass Spectrom. Section Abstract Doc Link 12672139 Disease Relevance 0 Pain Relevance 0.06
Since extracellular voltage signals may be influenced by currents arising at distant locations we used simulations of eAP generation in two compartmental models to verify that our recordings were dominated by local current sources in the initial segment and first node and that multisite extracellular recordings can distinguish between the initiation of spikes at these two locations (see Supplemental Figs S1 and S2).
Gene_expression (generation) of eAP in spikes
2) Confidence 0.29 Published 2010 Journal The Journal of Physiology Section Body Doc Link PMC2887989 Disease Relevance 0 Pain Relevance 0.15
Furthermore, no metabolites of [(11)C]SMe-ADAM could be detected in the SERT-rich regions of the rat brain.
Gene_expression (detected) of SMe-ADAM in brain
3) Confidence 0.28 Published 2006 Journal Nucl. Med. Biol. Section Abstract Doc Link 16459259 Disease Relevance 0 Pain Relevance 0.50
Phase II study of direct intralesional gene transfer of allovectin-7, an HLA-B7/beta2-microglobulin DNA-liposome complex, in patients with metastatic melanoma.
Gene_expression (transfer) of allovectin-7 associated with pain and skin cancer
4) Confidence 0.03 Published 2001 Journal Clin. Cancer Res. Section Title Doc Link 11489803 Disease Relevance 0.64 Pain Relevance 0.13
Continuous production of a peptidic fraction containing the intermediate opioid peptide LVV-haemorphin-7 (LVVh-7) by peptic hydrolysis of bovine haemoglobin in a continuous membrane reactor.
Gene_expression (production) of LVV-haemorphin-7 associated with opioid
5) Confidence 0.02 Published 2003 Journal Biotechnol. Appl. Biochem. Section Title Doc Link 12558504 Disease Relevance 0 Pain Relevance 0.19

General Comments

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