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Context Info
Confidence 0.40
First Reported 2001
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 3.51
Pain Relevance 1.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il4) extracellular region (Il4)
Anatomy Link Frequency
T cells 6
Il4 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 78 100.00 Very High Very High Very High
Inflammation 138 99.98 Very High Very High Very High
Morphine 10 98.66 Very High Very High Very High
agonist 8 90.44 High High
chemokine 2 86.96 High High
drug abuse 1 86.88 High High
Arthritis 4 70.16 Quite High
Inflammatory mediators 3 67.40 Quite High
rheumatoid arthritis 5 49.60 Quite Low
Inflammatory response 7 46.12 Quite Low
Disease Link Frequency Relevance Heat
INFLAMMATION 151 99.98 Very High Very High Very High
Atherosclerosis 8 98.72 Very High Very High Very High
Targeted Disruption 24 98.44 Very High Very High Very High
Hypersensitivity Pneumonitis 1 95.08 Very High Very High Very High
Calcification 5 92.88 High High
Sprains And Strains 2 91.68 High High
Disease 25 91.44 High High
Inflammatory Bowel Disease 7 88.40 High High
Granuloma 3 88.16 High High
Colitis 43 87.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition in this paper, we show that chronic morphine treatment resulted in a decrease in IFNgamma and IL-2 mRNA and an increase in IL-4 and IL-5 mRNA accumulation in murine splenocytes.
Positive_regulation (increase) of Positive_regulation (accumulation) of IL-4 associated with morphine
1) Confidence 0.40 Published 2004 Journal J. Neuroimmunol. Section Abstract Doc Link 14741432 Disease Relevance 0.09 Pain Relevance 0.68
Morphine treatment increases IL-4 messenger RNA accumulation in PBMCs and increases IL-4 promoter activity in Jurkat T cells.
Positive_regulation (increases) of Positive_regulation (accumulation) of IL-4 in T cells
2) Confidence 0.34 Published 2001 Journal Surgery Section Body Doc Link 11490364 Disease Relevance 0 Pain Relevance 0
We have recently shown that in human memory CD4 T cells, stabilization of IL-4 and IL-13 mRNA by CD28 stimulation is mediated by p38 MAPK [60].
Positive_regulation (mediated) of Positive_regulation (stabilization) of IL-4 in T cells
3) Confidence 0.34 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526596 Disease Relevance 0.41 Pain Relevance 0.13
The function of CIITA in Th differentiation was first demonstrated by the observation of increased generation of IL-4 secreting CD4+ T cells in CIITA-/-I-E-transgenic mice (12).
Positive_regulation (increased) of Positive_regulation (generation) of IL-4 in T cells associated with targeted disruption
4) Confidence 0.30 Published 2006 Journal Journal of Korean Medical Science Section Body Doc Link PMC2721999 Disease Relevance 1.00 Pain Relevance 0.03
Activation of the VDR stimulates the protective effects of type 2 helper T (Th2) cells through the induction of cytokines such as IL4 and IL10 (Boonstra et al 2001; Barrat et al 2002).
Positive_regulation (stimulates) of Positive_regulation (induction) of IL4 associated with cytokine
5) Confidence 0.19 Published 2006 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1936265 Disease Relevance 0.62 Pain Relevance 0.05
reported anti-inflammatory effects of IL-4 or IL-13 are mediated through
Positive_regulation (mediated) of Positive_regulation (effects) of IL-4 associated with inflammation
6) Confidence 0.16 Published 2008 Journal PPAR Research Section Body Doc Link PMC2443396 Disease Relevance 0.88 Pain Relevance 0.47
Hemoglobin levels increase with an increase of IL-4 and a decrease of TNF-?
Positive_regulation (increase) of Positive_regulation (increase) of IL-4
7) Confidence 0.12 Published 2007 Journal Pediatr Nephrol Section Body Doc Link PMC1805051 Disease Relevance 0.44 Pain Relevance 0.22
While no response was detected in mice that received the unprocessed graft after four weeks, a slight elevation in IL-4 after twelve weeks in comparison to the sham-operated mice suggests a possible weak cellular Th2 response in these mice.
Positive_regulation (operated) of Positive_regulation (elevation) of IL-4
8) Confidence 0.10 Published 2006 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1459156 Disease Relevance 0.07 Pain Relevance 0.08

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