INT97436

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Context Info
Confidence 0.51
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.80
Pain Relevance 0.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il4) extracellular region (Il4)
Anatomy Link Frequency
NFAT 2
Il4 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 33 100.00 Very High Very High Very High
cytokine 20 97.76 Very High Very High Very High
Inflammatory response 8 91.00 High High
ischemia 13 50.00 Quite Low
Morphine 2 50.00 Quite Low
Pain 1 33.36 Quite Low
chemokine 2 19.44 Low Low
antagonist 7 7.28 Low Low
bradykinin 10 5.00 Very Low Very Low Very Low
agonist 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 42 100.00 Very High Very High Very High
African Trypanosomiasis 22 91.20 High High
Reperfusion Injury 32 88.72 High High
Trypanosomiasis 31 83.28 Quite High
Pressure And Volume Under Development 4 81.60 Quite High
Targeted Disruption 13 78.16 Quite High
Bacterial Infection 1 74.32 Quite High
Infection 53 62.36 Quite High
Immunization 1 57.88 Quite High
Sprains And Strains 7 57.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CONCLUSIONS: We conclude that morphine treatment promotes T(H2) differentiation through a mu-opioid receptor mechanism and that morphine treatment increases IL-4 transcription, in part, through an NFAT mechanism.


Positive_regulation (increases) of Transcription (transcription) of IL-4 in NFAT
1) Confidence 0.51 Published 2001 Journal Surgery Section Body Doc Link 11490364 Disease Relevance 0 Pain Relevance 0
We found that B1R gene deletion or antagonism resulted in higher expression of the anti-inflammatory GATA-3, IL-4 and IL-10 and lower transcription of the pro-inflammatory T-bet and IL-1?.
Positive_regulation (resulted) of Transcription (transcription) of IL-4 associated with inflammation
2) Confidence 0.17 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2516176 Disease Relevance 1.44 Pain Relevance 0.33
In this context an increased IL-4 mRNA level and a concomitant increase in the IgG1 antibodies against the VSG was observed in the trypanotolerant N'dama cattle infected with T. congolense but not in the trypanosusceptible Boran cattle [199].
Positive_regulation (increased) of Transcription (level) of IL-4
3) Confidence 0.02 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2826769 Disease Relevance 0.35 Pain Relevance 0.05

General Comments

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