INT97438

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Context Info
Confidence 0.67
First Reported 2001
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 17
Total Number 17
Disease Relevance 9.17
Pain Relevance 3.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il4) extracellular region (Il4)
Anatomy Link Frequency
T cells 3
thyroid 1
sciatic nerve 1
Th1 cells 1
NK cells 1
Il4 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 345 100.00 Very High Very High Very High
Inflammation 212 100.00 Very High Very High Very High
chemokine 31 100.00 Very High Very High Very High
metalloproteinase 3 100.00 Very High Very High Very High
Sciatic nerve 3 99.36 Very High Very High Very High
Eae 5 98.80 Very High Very High Very High
Inflammatory stimuli 9 98.08 Very High Very High Very High
Inflammatory response 28 92.60 High High
Neuropathic pain 1 91.48 High High
Neuritis 4 81.20 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 245 100.00 Very High Very High Very High
Cancer 19 100.00 Very High Very High Very High
Necrosis 12 100.00 Very High Very High Very High
Rhinitis 8 99.26 Very High Very High Very High
Injury 16 98.80 Very High Very High Very High
Bites And Stings 8 98.56 Very High Very High Very High
Hypersensitivity 18 97.16 Very High Very High Very High
Immunization 14 94.56 High High
Targeted Disruption 111 93.72 High High
Hyperplasia 15 92.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This work provides the first description of the generation, characterization, and functional analysis of a smooth muscle cell–specific IL-4R?
Transcription (description) of IL-4 in smooth muscle cell
1) Confidence 0.67 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1769405 Disease Relevance 0.47 Pain Relevance 0.07
To investigate the very early temporal pattern of cytokine regulation we studied 140 mice of C57Bl/6J background after chronic constriction injury (CCI) of the right sciatic nerve and measured the relative mRNA expression of the pro-inflammatory cytokines tumor necrosis factor-alpha (TNF) and interleukin-1beta (IL-1beta) and of the anti-inflammatory cytokines IL-4 and IL-10 with quantitative real-time polymerase chain reaction (qRT-PCR).
Transcription (expression) of IL-4 in sciatic nerve associated with necrosis, inflammation, cancer, eae, injury, sciatic nerve and cytokine
2) Confidence 0.67 Published 2007 Journal Brain Behav. Immun. Section Abstract Doc Link 17204395 Disease Relevance 1.15 Pain Relevance 0.76
Notably, expression of mRNA encoding the Th2 signature cytokine IL-4 was up-regulated 2791-fold at tick bite sites (P < 0.001) and 527-fold at intradermal injection sites (P < 0.001) of 10 ?
Transcription (expression) of IL-4 associated with bites and stings and cytokine
3) Confidence 0.58 Published 2009 Journal Parasit Vectors Section Body Doc Link PMC2764639 Disease Relevance 0.32 Pain Relevance 0.18
Concentrations of IL-4 protein in the optic nerve declined slightly in 19 days. mRNA expression of IL-17, IFN-gamma and IL-4 was consistent with their protein expression.
Transcription (expression) of IL-4 in optic nerve
4) Confidence 0.54 Published 2010 Journal Int. J. Mol. Med. Section Abstract Doc Link 20428790 Disease Relevance 0.80 Pain Relevance 0.37
CONCLUSIONS: We conclude that morphine treatment promotes T(H2) differentiation through a mu-opioid receptor mechanism and that morphine treatment increases IL-4 transcription, in part, through an NFAT mechanism.


Transcription (transcription) of IL-4 in NFAT
5) Confidence 0.53 Published 2001 Journal Surgery Section Body Doc Link 11490364 Disease Relevance 0 Pain Relevance 0
Morphine regulation of IL-4 transcription was investigated in PBMCs (IL-4 messenger RNA, nuclear factor of activated T-cells) and Jurkat T cells transfected with a murine IL-4 promoter-luciferase construct.
Transcription (transcription) of IL-4 in T cells
6) Confidence 0.53 Published 2001 Journal Surgery Section Body Doc Link 11490364 Disease Relevance 0 Pain Relevance 0
A subsequent experiment has suggested that the competition between CIITA and NF-AT for binding to CPB/p300 is critical for the suppression of IL-4 transcription by T cells (8).
Transcription (transcription) of IL-4 in T cells
7) Confidence 0.44 Published 2006 Journal Journal of Korean Medical Science Section Body Doc Link PMC2721999 Disease Relevance 0.28 Pain Relevance 0.08
Although CIITA was initially described as a master regulator of MHC class II transcription, it is now clear that it can both activate and suppress transcription of several genes such as collagen (6), matrix metalloproteinase-9 (7), IL-4 (8), Fas ligand (9) and thyroid specific genes (10, 11).
Transcription (transcription) of IL-4 in thyroid associated with metalloproteinase
8) Confidence 0.44 Published 2006 Journal Journal of Korean Medical Science Section Body Doc Link PMC2721999 Disease Relevance 0.12 Pain Relevance 0.08
In addition, a transfection study has shown that CIITA might suppress IL-4 transcription in Th1 cells by competing with NF-AT for binding to the general coactivator CBP (8).
Transcription (transcription) of IL-4 in Th1 cells
9) Confidence 0.34 Published 2006 Journal Journal of Korean Medical Science Section Body Doc Link PMC2721999 Disease Relevance 0.79 Pain Relevance 0
Significantly lower amounts of IL-4 were also found in the Con-A-stimulated cultures of splenocytes harvested from the Bv8-treated animals (Fig. 5, panel C).


Transcription (found) of IL-4
10) Confidence 0.28 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2584092 Disease Relevance 0.06 Pain Relevance 0.14
We found that B1R gene deletion or antagonism resulted in higher expression of the anti-inflammatory GATA-3, IL-4 and IL-10 and lower transcription of the pro-inflammatory T-bet and IL-1?.
Transcription (transcription) of IL-4 associated with inflammation
11) Confidence 0.26 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2516176 Disease Relevance 1.32 Pain Relevance 0.33
inflammation such as eosinophilic, lymphocytic infiltration, and mRNA expression for IL-4 and IL-5 [23].
Transcription (expression) of IL-4 associated with rhinitis and inflammation
12) Confidence 0.26 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2276601 Disease Relevance 2.17 Pain Relevance 0.52
Expression of mRNA for murine IL-4, IL-5, IL-6, IL-33 and ST2 were determined using commercially available FAM-labeled Taqman primers and probes (Applied Biosystems) on cDNA derived from mRNA extracted using a Qiagen RNeasy mRNA isolation kit.
Spec (determined) Transcription (Expression) of IL-4
13) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2914748 Disease Relevance 0.15 Pain Relevance 0
Concurrently, pulmonary NK cells exhibited a gradual increase in the expression of IL-4 transcripts, but not of IL-5 or IL-13.
Transcription (transcripts) of IL-4 in NK cells
14) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2887844 Disease Relevance 0.34 Pain Relevance 0.20
Important mediators of this embankment are IL-4 and IL-13, which as described above repress the induction of IL-12, and thus put a brake on the positive feed-back loop of IFN-?
Transcription (described) of IL-4
15) Confidence 0.17 Published 2005 Journal Virol J Section Body Doc Link PMC1215526 Disease Relevance 0.34 Pain Relevance 0.31
, IL-2, IL-3, IL-4, IL-6, IL-10,IL-17, GM-CSF, KC, and Rantes were the best discriminators of the BCG response relative to TNF-?
Transcription (discriminators) of IL-4 associated with chemokine
16) Confidence 0.10 Published 2007 Journal BMC Immunol Section Body Doc Link PMC1891101 Disease Relevance 0.53 Pain Relevance 0.31
In this context an increased IL-4 mRNA level and a concomitant increase in the IgG1 antibodies against the VSG was observed in the trypanotolerant N'dama cattle infected with T. congolense but not in the trypanosusceptible Boran cattle [199].
Transcription (level) of IL-4
17) Confidence 0.03 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2826769 Disease Relevance 0.35 Pain Relevance 0.05

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