INT97439

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Context Info
Confidence 0.60
First Reported 2001
Last Reported 2011
Negated 2
Speculated 1
Reported most in Body
Documents 46
Total Number 48
Disease Relevance 25.60
Pain Relevance 9.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il5) extracellular region (Il5)
Anatomy Link Frequency
T-cell 4
lung 3
plasma 1
eosinophils 1
basophils 1
Il5 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 796 100.00 Very High Very High Very High
Inflammation 1286 99.40 Very High Very High Very High
Central nervous system 56 98.32 Very High Very High Very High
Morphine 18 98.30 Very High Very High Very High
Inflammatory response 49 96.40 Very High Very High Very High
chemokine 130 95.76 Very High Very High Very High
drug abuse 2 94.72 High High
antagonist 49 93.88 High High
cINOD 11 90.40 High High
agonist 40 89.40 High High
Disease Link Frequency Relevance Heat
Eosinophilia 43 99.90 Very High Very High Very High
Metaplasia 5 99.88 Very High Very High Very High
Lymphatic System Cancer 8 99.58 Very High Very High Very High
Asthma 786 99.48 Very High Very High Very High
INFLAMMATION 1309 99.40 Very High Very High Very High
Rhinitis 104 99.14 Very High Very High Very High
Targeted Disruption 35 98.80 Very High Very High Very High
Diabetes Mellitus 692 98.60 Very High Very High Very High
Disease 472 98.58 Very High Very High Very High
Aspergillus Infection 46 98.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These functional changes were associated with lymphocytic/eosinophilic inflammation, goblet cell metaplasia, and increased concentrations of IL-5 and IL-13 in the BALF.
Positive_regulation (increased) of IL-5 in goblet cell associated with rhinitis, inflammation and metaplasia
1) Confidence 0.60 Published 2002 Journal Am. J. Physiol. Lung Cell Mol. Physiol. Section Abstract Doc Link 12225955 Disease Relevance 1.03 Pain Relevance 0.25
Eosinophilia, a hallmark of both helminth infections and atopic diseases, is maintained through upregulation of eosinophilopoiesis by means of increased production and effectiveness of Interleukin-5 (IL-5), a major Th2 cytokine.
Positive_regulation (increased) of IL-5 associated with worm infection, disease, eosinophilia and cytokine
2) Confidence 0.47 Published 2007 Journal Curr. Med. Chem. Section Abstract Doc Link 17691935 Disease Relevance 0.83 Pain Relevance 0.23
The allergen-induced increase in interleukin-5 levels was also dose-dependently inhibited by budesonide.
Positive_regulation (increase) of interleukin-5
3) Confidence 0.45 Published 2004 Journal BMC Pharmacol Section Body Doc Link PMC406499 Disease Relevance 0.28 Pain Relevance 0.14
In addition in this paper, we show that chronic morphine treatment resulted in a decrease in IFNgamma and IL-2 mRNA and an increase in IL-4 and IL-5 mRNA accumulation in murine splenocytes.
Positive_regulation (accumulation) of IL-5 associated with morphine
4) Confidence 0.38 Published 2004 Journal J. Neuroimmunol. Section Abstract Doc Link 14741432 Disease Relevance 0.09 Pain Relevance 0.68
We had previously shown that chronic morphine treatment in vivo and in vitro decreases IL-2 and IFNgamma (Th1) protein levels and increases IL-4 and IL-5 (Th2) protein levels in a time-dependent manner.
Positive_regulation (increases) of IL-5 associated with morphine
5) Confidence 0.38 Published 2004 Journal J. Neuroimmunol. Section Abstract Doc Link 14741432 Disease Relevance 0.09 Pain Relevance 0.54
IL-5 (Figure 2B) was also enhanced in groups treated with 50 and 500 ug ATRA (50 ug; mean: 151 ng/ml; 500 ug: 149 ng/ml) compared to non-treated mice (0 ug; mean: 98 ng/ml).
Positive_regulation (enhanced) of IL-5
6) Confidence 0.37 Published 2009 Journal Nutr Metab (Lond) Section Body Doc Link PMC2773769 Disease Relevance 0.32 Pain Relevance 0.12
The maximal secretion ranged from as early as 2 - 4 h for TNF-alpha to 8 - 12 h, with a long lasting elevation, for IL-5 and IL-13 [31].
Positive_regulation (elevation) of IL-5
7) Confidence 0.37 Published 2010 Journal BMC Immunol Section Body Doc Link PMC2898835 Disease Relevance 0.41 Pain Relevance 0.31
In contrast, chronic stress significantly increased the cell numbers and the contents of IL-4 and IL-5 in both mouse strains.
Positive_regulation (increased) of IL-5
8) Confidence 0.32 Published 2007 Journal Allergol Int Section Body Doc Link 17259807 Disease Relevance 0 Pain Relevance 0
, increased IL10 and IL5) was observed during treatment as compared to baseline [209].
Positive_regulation (increased) of IL5
9) Confidence 0.31 Published 2011 Journal Biol Sex Differ Section Body Doc Link PMC3022636 Disease Relevance 0.56 Pain Relevance 0.22
Chronic OVA challenge induced a similar significant increase in levels of lung IL-5 and IL-13 in Siglec-F deficient and WT mice.
Positive_regulation (increase) of IL-5 in lung
10) Confidence 0.30 Published 2010 Journal Respir Res Section Body Doc Link PMC2988013 Disease Relevance 0.62 Pain Relevance 0.27
and IL6, with increased IL5), as well as decreasing pathology in the CNS.
Positive_regulation (increased) of IL5 associated with central nervous system
11) Confidence 0.29 Published 2011 Journal Biol Sex Differ Section Body Doc Link PMC3022636 Disease Relevance 0.84 Pain Relevance 0.24
Moreover, we have also found an increase in IL-5 in the plasma of treated mice during the first day of cSN50 therapy.
Positive_regulation (increase) of IL-5 in plasma
12) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2950856 Disease Relevance 0.88 Pain Relevance 0.36
We did not find increased levels of IL-4 or IL-13 and thus it is unclear whether this increased IL-5 is indicative of a shift towards a Th2 phenotype.
Spec (whether) Positive_regulation (increased) of IL-5
13) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2950856 Disease Relevance 0.79 Pain Relevance 0.31
Mouse IL-4, IL-5, IL-13, and IFN-?.
Positive_regulation (Mouse) of IL-5 in Mouse
14) Confidence 0.26 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2276601 Disease Relevance 0.13 Pain Relevance 0.12
As shown in Figures 4A and 4B, IL-5 and IL-13 levels from OVA-challenged and PBS-treated mice of the positive control group were markedly increased compared to the negative control group (challenged and treated with PBS).
Positive_regulation (increased) of IL-5
15) Confidence 0.25 Published 2010 Journal BMC Immunol Section Body Doc Link PMC2898835 Disease Relevance 0.36 Pain Relevance 0.33
The mean IL-4, IL-5, and TNF-?
Positive_regulation (mean) of IL-5
16) Confidence 0.24 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2994734 Disease Relevance 0.51 Pain Relevance 0.26
Because IgE levels in BALF are dependent upon IL-4, IL-5, IL-13 and may be considered
Positive_regulation (dependent) of IL-5
17) Confidence 0.24 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2276601 Disease Relevance 0.28 Pain Relevance 0.13
RESULTS: Morphine treatment of PBMCs decreases IL-2 and IFN gamma and increases IL-4 and IL-5 as a function of morphine concentration.
Positive_regulation (increases) of IL-5
18) Confidence 0.23 Published 2001 Journal Surgery Section Body Doc Link 11490364 Disease Relevance 0 Pain Relevance 0
The lower levels of IL-5 and IL-13 observed in the lung are likely a result of decreased recruitment of T cells since CD3+ T cells were seen to be reduced in the lung after H4R antagonist treatment, but not by anti-IL-13 treatment.
Positive_regulation (levels) of IL-5 in T cells associated with antagonist
19) Confidence 0.21 Published 2010 Journal Respir Res Section Body Doc Link PMC2914735 Disease Relevance 0.67 Pain Relevance 0.30
The combined exposure to whole DEP + OVA resulted in a further significant increase in IL-5.
Positive_regulation (increase) of IL-5
20) Confidence 0.21 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2127221 Disease Relevance 0 Pain Relevance 0.09

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