INT97443

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Context Info
Confidence 0.50
First Reported 1999
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 13
Total Number 13
Disease Relevance 11.91
Pain Relevance 2.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (LEP) extracellular region (LEP) lipid metabolic process (LEP)
Anatomy Link Frequency
chondrocytes 4
hypothalamus 2
fat 2
nerve 2
LEP (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 42 99.96 Very High Very High Very High
Inflammatory response 2 99.92 Very High Very High Very High
Endep 3 99.64 Very High Very High Very High
Osteoarthritis 183 99.62 Very High Very High Very High
Inflammation 32 97.68 Very High Very High Very High
Cholecystokinin 6 93.36 High High
headache 3 91.68 High High
Dynorphin 1 88.48 High High
Migraine 4 87.36 High High
Opioid 3 87.12 High High
Disease Link Frequency Relevance Heat
Insulin Resistance 45 100.00 Very High Very High Very High
Anorexia 11 99.84 Very High Very High Very High
INFLAMMATION 40 99.74 Very High Very High Very High
Osteoarthritis 182 99.62 Very High Very High Very High
Obesity 647 99.56 Very High Very High Very High
Appetite Loss 11 98.64 Very High Very High Very High
Aging 54 97.24 Very High Very High Very High
Disease 31 96.64 Very High Very High Very High
Metabolic Syndrome 156 96.28 Very High Very High Very High
Body Weight 26 96.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
On the contrary, other hypothalamic and extrahypothalamic sites appear to continue relatively sensitive to the actions of leptin, including the ventromedial hypothalamic nuclei, which has been previously shown to mediate leptin-induced sympathetic nerve activation (Satoh et al 1999).
Positive_regulation (mediate) of Positive_regulation (activation) of leptin-induced in nerve
1) Confidence 0.50 Published 2006 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993994 Disease Relevance 0.50 Pain Relevance 0.03
Circulating leptin levels were increased on day one after total abdominal hysterectomy.
Positive_regulation (increased) of Positive_regulation (Circulating) of leptin
2) Confidence 0.49 Published 2001 Journal Endocr. J. Section Abstract Doc Link 11603576 Disease Relevance 0.51 Pain Relevance 0.07
induction of leptin may play a significant role in anorexia and
Positive_regulation (role) of Positive_regulation (induction) of leptin associated with anorexia
3) Confidence 0.48 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC1804295 Disease Relevance 1.98 Pain Relevance 0.47
As a defect in leptin action on body weight homeostasis has been reported for obese individuals despite high serum leptin concentrations, the current study was undertaken to determine whether chondrocytes from obese OA patients that are exposed to elevated leptin levels, exhibit an altered response to leptin.
Positive_regulation (exposed) of Positive_regulation (elevated) of leptin in chondrocytes associated with body weight, obesity and osteoarthritis
4) Confidence 0.47 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911905 Disease Relevance 1.42 Pain Relevance 0.13
Those effects of leptin seem to be dependent on activation of transcription factor NF-?
Positive_regulation (dependent) of Positive_regulation (effects) of leptin
5) Confidence 0.47 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2726438 Disease Relevance 0.45 Pain Relevance 0.29
By contrast, leptin up-regulated gene expression in a dose-dependent manner in chondrocytes collected from obese OA patients as cells required an elevated level of leptin to be responsive (Figure 2).
Positive_regulation (required) of Positive_regulation (elevated) of leptin in chondrocytes associated with obesity and osteoarthritis
6) Confidence 0.44 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911905 Disease Relevance 1.26 Pain Relevance 0.12
Both cyproheptadine and flunarizine (but not amitriptyline and propranolol) caused an increase in leptin levels (P < 0.05).
Positive_regulation (caused) of Positive_regulation (increase) of leptin associated with endep
7) Confidence 0.42 Published 2009 Journal Pediatr. Neurol. Section Abstract Doc Link 19748048 Disease Relevance 0.54 Pain Relevance 0.86
First, there appears to be a threshold plasma leptin concentration (~25 ng/ml) above which the uptake of leptin into the hypothalamus does not increase anymore in spite of high values of leptin (i.e. leptin receptor saturation).
Neg (not) Positive_regulation (increase) of Positive_regulation (values) of leptin in hypothalamus
8) Confidence 0.36 Published 2005 Journal J Int Soc Sports Nutr Section Body Doc Link PMC2129146 Disease Relevance 0.54 Pain Relevance 0
In this model, increases in body fat lead to increases in aromatase levels, in addition to insulin resistance, adverse lipid profiles and increased leptin levels.
Positive_regulation (increases) of Positive_regulation (increased) of leptin in fat associated with insulin resistance
9) Confidence 0.26 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2544367 Disease Relevance 1.18 Pain Relevance 0
In men, testosterone inhibits leptin, and the fall in testosterone with age results in an increase in leptin concentrations.
Positive_regulation (results) of Positive_regulation (increase) of leptin
10) Confidence 0.24 Published 1999 Journal Nestle Nutr Workshop Ser Clin Perform Programme Section Abstract Doc Link 11490597 Disease Relevance 0.74 Pain Relevance 0.20
It is uncertain whether the early trigger is insulin resistance or a chronic inflammatory response to increased circulating leptin and reduced adiponectin.
Spec (whether) Positive_regulation (increased) of Spec (whether) Positive_regulation (increased) of leptin associated with inflammatory response and insulin resistance
11) Confidence 0.20 Published 2007 Journal Core Evidence Section Body Doc Link PMC3012438 Disease Relevance 1.74 Pain Relevance 0.05
The decline in testosterone levels in older males leads to increased leptin levels and this may explain the greater decline in food intake with aging in the male.
Positive_regulation (leads) of Positive_regulation (increased) of leptin associated with aging
12) Confidence 0.14 Published 2001 Journal J. Gerontol. A Biol. Sci. Med. Sci. Section Abstract Doc Link 11730241 Disease Relevance 0.83 Pain Relevance 0.30
Intake of food depresses the hunger signals and leads to an increase in satiety signals such as CCK, GLP-1, PYY, insulin, and leptin.
Positive_regulation (leads) of Positive_regulation (increase) of leptin
13) Confidence 0.04 Published 2010 Journal Chemical Reviews Section Body Doc Link PMC2855180 Disease Relevance 0.22 Pain Relevance 0.11

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