INT97449

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Context Info
Confidence 0.69
First Reported 2001
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 4.28
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (Mitf) cell differentiation (Mitf) nucleus (Mitf)
protein complex assembly (Mitf) DNA binding (Mitf) protein complex (Mitf)
Anatomy Link Frequency
granulocytes 1
monocytes 1
Mitf (Mus musculus)
Pain Link Frequency Relevance Heat
melanocortin 1 receptor 1 86.20 High High
Inflammatory response 14 46.24 Quite Low
Inflammation 86 36.52 Quite Low
substance P 6 22.48 Low Low
interstitial cystitis 8 5.00 Very Low Very Low Very Low
Inflammatory stimuli 6 5.00 Very Low Very Low Very Low
metalloproteinase 6 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
palliative 2 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Microphthalmia 49 100.00 Very High Very High Very High
Melanoma 146 98.72 Very High Very High Very High
Leukemia 2 96.72 Very High Very High Very High
Renal Cancer 6 91.56 High High
Cancer 92 91.32 High High
Genetic Translocation 2 83.12 Quite High
Metastasis 26 77.88 Quite High
Stress 2 75.00 Quite High
Experimental Melanoma 3 64.96 Quite High
Skin Cancer 5 61.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
BRN2 has been reported to be a negative regulator of MITF in melanoma cells [22], yet we were unable to show any correlation between MITF and BRN2 transcription in this study, with any potential correlation tending towards positive rather than negative at the transcript level.
Transcription (transcription) of MITF associated with melanoma
1) Confidence 0.69 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2794539 Disease Relevance 1.09 Pain Relevance 0
MITF transcript levels did not correlate with CD200 expression in NZM cell lines (Figure S3), whereas MLANA, a transcriptional target of MITF, strongly correlated with MITF expression as expected (Figure S3).
Transcription (target) of MITF
2) Confidence 0.67 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2794539 Disease Relevance 0.20 Pain Relevance 0
MiTF mRNA and protein levels are higher in human mast cells than monocytes and granulocytes [55].
Transcription (levels) of MiTF in granulocytes associated with microphthalmia
3) Confidence 0.35 Published 2007 Journal BMC Immunol Section Body Doc Link PMC2000913 Disease Relevance 1.31 Pain Relevance 0
Recovery of basal Mitf mRNA levels was also observed clearly before that of tyrosinase.
Transcription (levels) of Mitf
4) Confidence 0.30 Published 2001 Journal J. Cell. Sci. Section Abstract Doc Link 11493672 Disease Relevance 0.37 Pain Relevance 0.09
MiTF mRNA and protein levels are higher in human mast cells than monocytes and granulocytes [55].
Transcription (levels) of MiTF in monocytes associated with microphthalmia
5) Confidence 0.12 Published 2007 Journal BMC Immunol Section Body Doc Link PMC2000913 Disease Relevance 1.31 Pain Relevance 0

General Comments

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