INT97451

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Context Info
Confidence 0.41
First Reported 2001
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 0.88
Pain Relevance 0.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (Mitf) cell differentiation (Mitf) nucleus (Mitf)
protein complex assembly (Mitf) DNA binding (Mitf) protein complex (Mitf)
Anatomy Link Frequency
melanocyte 2
Mitf (Mus musculus)
Pain Link Frequency Relevance Heat
melanocortin 1 receptor 30 93.88 High High
metalloproteinase 9 5.00 Very Low Very Low Very Low
agonist 4 5.00 Very Low Very Low Very Low
palliative 3 5.00 Very Low Very Low Very Low
depression 3 5.00 Very Low Very Low Very Low
Kinase C 1 5.00 Very Low Very Low Very Low
antagonist 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Microphthalmia 5 100.00 Very High Very High Very High
Melanoma 219 99.54 Very High Very High Very High
Stress 2 75.00 Quite High
Experimental Melanoma 4 72.64 Quite High
Skin Cancer 9 69.40 Quite High
Injury 3 47.36 Quite Low
Cancer 135 22.88 Low Low
Metastasis 39 5.00 Very Low Very Low Very Low
Nevus 21 5.00 Very Low Very Low Very Low
Hypoxia 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Genomic amplification of the MITF locus, which may occur in 10–15% of metastatic melanomas [23], was unlikely to underlie the differential expression of MITF between our Motif 1 and 2 NZM cell lines as there was no difference in MITF copy number between NZM cell lines with varying levels of relative MITF gene expression (Figure S3).


Negative_regulation (underlie) of Gene_expression (expression) of MITF associated with melanoma
1) Confidence 0.41 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2794539 Disease Relevance 0.33 Pain Relevance 0
Further, expression of the POU3F2 (BRN2) transcription factor, which was reported to be a negative regulator of MITF expression [22], did not inversely correlate with MITF transcript levels in NZM cell lines (Figure S3).
Negative_regulation (regulator) of Gene_expression (expression) of MITF
2) Confidence 0.41 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2794539 Disease Relevance 0.15 Pain Relevance 0
Le Pape et al. (2009) have also now reported a valuable microarray analysis of gene expression changes in melan-a cells grown with ASIP, which supports the concept of partial dedifferentiation and complements the present findings; for example reduced expression of a large number of pigmentary genes including Mitf was noted after growth with ASIP.
Negative_regulation (reduced) of Gene_expression (expression) of Mitf
3) Confidence 0.40 Published 2009 Journal Pigment Cell & Melanoma Research Section Body Doc Link PMC2784899 Disease Relevance 0 Pain Relevance 0.07
After blocking, the membrane was probed with a primary antibody to either MITF (Zymed; 1?
Negative_regulation (blocking) of Gene_expression (probed) of MITF
4) Confidence 0.36 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2794539 Disease Relevance 0 Pain Relevance 0
Downregulation of melanocyte differentiation markers mRNAs was preceded by a decrease in microphthalmia transcription factor (Mitf) gene expression, which was quantitatively similar to the decrease achieved using 12-O-tetradecanoylphorbol-13-acetate.
Negative_regulation (decrease) of Gene_expression (expression) of Mitf in melanocyte associated with microphthalmia
5) Confidence 0.24 Published 2001 Journal J. Cell. Sci. Section Abstract Doc Link 11493672 Disease Relevance 0.39 Pain Relevance 0.09

General Comments

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