INT97452

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Context Info
Confidence 0.39
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 20
Total Number 24
Disease Relevance 11.40
Pain Relevance 2.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (MOCS1) small molecule metabolic process (MOCS1) nucleus (MOCS1)
Anatomy Link Frequency
plasma 1
liver 1
muscle 1
abdomen 1
platelet 1
MOCS1 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 9 99.82 Very High Very High Very High
cytokine 17 99.60 Very High Very High Very High
pregabalin 124 96.16 Very High Very High Very High
metalloproteinase 19 95.96 Very High Very High Very High
antiepileptic Drug 17 95.72 Very High Very High Very High
Calcium channel 13 93.48 High High
Inflammation 35 89.24 High High
abdominal pain 2 88.04 High High
Angina 8 86.24 High High
melanocortin 1 receptor 1 84.24 Quite High
Disease Link Frequency Relevance Heat
Myocardial Infarction 61 99.84 Very High Very High Very High
Fabry Disease 140 99.32 Very High Very High Very High
Diabetes Mellitus 53 98.28 Very High Very High Very High
Lactic Acidosis 8 98.16 Very High Very High Very High
Prediabetic State 6 97.64 Very High Very High Very High
Pancreatitis 4 97.32 Very High Very High Very High
Metabolic Syndrome 8 97.12 Very High Very High Very High
Insulin Resistance 12 96.32 Very High Very High Very High
Coronary Artery Disease 12 96.24 Very High Very High Very High
Stress 27 93.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Later, serum pancreatic enzyme levels were elevated and a computed tomography scan of the abdomen was consistent with pancreatitis.
Positive_regulation (elevated) of enzyme in abdomen associated with pancreatitis
1) Confidence 0.39 Published 2003 Journal Pancreatology Section Abstract Doc Link 14730176 Disease Relevance 0.89 Pain Relevance 0.13
Two new kynurenine analogues, 3-hydroxydesaminokynurenine and 3- methoxydesami-nokynurenine, were synthesised as inhibitors of kynureninase and tested on the tryptophan-induced bacterial enzyme from Pseudomonas fluorescens, the recombinant human enzyme and the rat hepatic enzyme.
Positive_regulation (induced) of enzyme
2) Confidence 0.01 Published 2005 Journal BMC Bioinformatics Section Body Doc Link PMC1187874 Disease Relevance 0.55 Pain Relevance 0.03
They concluded that thrombolytic therapy generates at least two potent antithrombotic factors in the circulation, namely the fibrinolytic enzyme, plasmin, and the anticoagulation enzyme, protein Ca.
Positive_regulation (generates) of enzyme
3) Confidence 0.01 Published 2004 Journal Journal of Korean Medical Science Section Body Doc Link PMC2816339 Disease Relevance 0.40 Pain Relevance 0
They concluded that thrombolytic therapy generates at least two potent antithrombotic factors in the circulation, namely the fibrinolytic enzyme, plasmin, and the anticoagulation enzyme, protein Ca.
Positive_regulation (generates) of enzyme
4) Confidence 0.01 Published 2004 Journal Journal of Korean Medical Science Section Body Doc Link PMC2816339 Disease Relevance 0.46 Pain Relevance 0
It is known that enzyme activity can be stimulated by small molecule activators.
Positive_regulation (stimulated) of enzyme
5) Confidence 0.01 Published 2010 Journal Current Chemical Genomics Section Body Doc Link PMC2995157 Disease Relevance 0.48 Pain Relevance 0
However, increasing mutant enzyme activities with an inhibitor may not be an ideal solution in vivo, as the chaperone action may be functionally compromised by the inhibition of enzyme activity.
Positive_regulation (increasing) of enzyme
6) Confidence 0.01 Published 2010 Journal Current Chemical Genomics Section Body Doc Link PMC2995157 Disease Relevance 0.91 Pain Relevance 0.04
Therefore, the discovery of small molecules that assist mutant enzymes to fold correctly may rescue them from premature degradation and increase the amount of active enzyme in the lysosomes.


Positive_regulation (increase) of enzyme
7) Confidence 0.01 Published 2010 Journal Current Chemical Genomics Section Body Doc Link PMC2995157 Disease Relevance 0.62 Pain Relevance 0.06
This usually can be done either by determining if the lead compounds are able to increase enzyme activity in whole cells or by visualizing decreased substrate storage or increased GLA protein in lysosomes.


Positive_regulation (increase) of enzyme
8) Confidence 0.01 Published 2010 Journal Current Chemical Genomics Section Body Doc Link PMC2995157 Disease Relevance 0 Pain Relevance 0
If an enzyme activator is used as a therapy, both the chaperone and enzyme stimulatory actions of the activator would synergistically increase enzyme activity in the lysosomes.
Positive_regulation (increase) of enzyme
9) Confidence 0.01 Published 2010 Journal Current Chemical Genomics Section Body Doc Link PMC2995157 Disease Relevance 0.73 Pain Relevance 0.03
Here we describe the identification of chemotypes that potently inhibit human 15-PGDH, with either competitive or noncompetitive kinetics, and strongly stabilize the enzyme in a cofactor-dependent manner.
Positive_regulation (stabilize) of enzyme
10) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2970562 Disease Relevance 0.21 Pain Relevance 0.27
Both types of inhibitors caused strong thermal stabilization of the enzyme, with cofactor dependencies correlating with their mechanism of action.
Positive_regulation (stabilization) of enzyme
11) Confidence 0.01 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2970562 Disease Relevance 0.07 Pain Relevance 0.03
Compound 13 additionally also reduced the apparent Km by half at a concentration of 10 nM, suggesting that the affinity of the enzyme for the substrate was increased by the inhibitor, consistent with a mode of uncompetitive or mixed-type inhibition.
Positive_regulation (increased) of enzyme
12) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2970562 Disease Relevance 0 Pain Relevance 0
ISZ works only if active, uninhibited enzyme is present, which means enzyme RNA must have been synthesised, translated to pro-enzyme and the pro-enzyme activated.
Positive_regulation (activated) of enzyme
13) Confidence 0.01 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206387 Disease Relevance 0 Pain Relevance 0
ISZ works only if active, uninhibited enzyme is present, which means enzyme RNA must have been synthesised, translated to pro-enzyme and the pro-enzyme activated.
Positive_regulation (activated) of enzyme
14) Confidence 0.01 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206387 Disease Relevance 0 Pain Relevance 0
A positive energetic balance is desirable; “fast” carbohydrates should be avoided as this may lead to excessive lactic acidosis.Many single substances have been tried with the rationale of bypassing defective pathways, increasing residual enzyme activities, or having an antioxidant function.
Positive_regulation (increasing) of enzyme associated with lactic acidosis
15) Confidence 0.01 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2877206 Disease Relevance 0.27 Pain Relevance 0.04
Phosphofructokinase is a tetrameric enzyme derived from 3 distinct genetic loci that code for muscle, liver, and platelet isoforms.
Positive_regulation (derived) of enzyme in platelet
16) Confidence 0.01 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2877206 Disease Relevance 0.32 Pain Relevance 0
MMP-9 activity is controlled at different levels: transcriptional activation of the gene by cytokines and other factors, activation of the pro-enzyme by various enzymes like serine proteases and regulation by specific tissue inhibitors of the matrix metalloproteinases (TIMPs).
Positive_regulation (activation) of enzyme associated with metalloproteinase and cytokine
17) Confidence 0.01 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2667508 Disease Relevance 0.87 Pain Relevance 0.48
Enzyme activities also recovered, beginning to increase 16-20 hours after the treatment.
Positive_regulation (increase) of Enzyme
18) Confidence 0.01 Published 2001 Journal J. Cell. Sci. Section Abstract Doc Link 11493672 Disease Relevance 0.40 Pain Relevance 0.08
Important agonists for the activation of the eNOS enzyme (table 7) play an important role in the production of eNO.
Positive_regulation (activation) of enzyme associated with agonist
19) Confidence 0.01 Published 2003 Journal Cardiovasc Diabetol Section Body Doc Link PMC151667 Disease Relevance 1.32 Pain Relevance 0.05
In the absence of hepatic enzyme induction, >80% of a single dose is excreted unchanged in the urine.[51] When given along with hepatic enzyme inducers about 40-50% of the dose is metabolized.[5253] In the absence of enzyme induction mean plasma elimination half life is 19-23 hour and in the presence of the enzyme inducers plasma half life is reduced to 12-15 hours.[54] In vitro studies have shown that topiramate inhibits CYP2C19.[55] The plasma concentration of topiramate is reduced by 40% and 48%, when coadministered with carbamazepine and phenytoin respectively.[5253] When administered with valproate the plasma concentration of topiramate reduces by 17% and concentration of valproate increases by 11%.[56] When given with drugs like oral contraceptives and digoxin, topiramate reduces their levels.[5758] The usual dose of topiramate is 200-400 mg/day.
Positive_regulation (induction) of enzyme in plasma associated with carbamazepine
20) Confidence 0.01 Published 2007 Journal Indian Journal of Psychiatry Section Body Doc Link PMC2899994 Disease Relevance 0.21 Pain Relevance 0.37

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