INT9746

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Context Info
Confidence 0.36
First Reported 1992
Last Reported 2007
Negated 2
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0
Pain Relevance 0.35

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cytosol (NR1I3) nucleoplasm (NR1I3) signal transduction (NR1I3)
cytoskeleton (NR1I3) nucleus (NR1I3) DNA binding (NR1I3)
Anatomy Link Frequency
CAR 1
NR1I3 (Homo sapiens)
Pain Link Frequency Relevance Heat
anesthesia 3 85.92 High High
medulla 1 77.44 Quite High
Analgesic 1 73.12 Quite High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The interpeak latencies of I-III and I-V were not affected.
Neg (not) Regulation (affected) of I-III
1) Confidence 0.36 Published 1992 Journal Masui Section Abstract Doc Link 1433871 Disease Relevance 0 Pain Relevance 0.28
Further investigation of metamizole and various derivatives on different potential target genes in human primary hepatocytes demonstrated time- and concentration-dependent induction by metamizole of CYP2B6 (7.8- and 3.1-fold for mRNA and protein, respectively, at 100 muM) and CYP3A4 (2.4- and 2.9-fold, respectively), whereas other genes (CYP2C9, CYP2C19, CYP2D6, NADPH:cytochrome P450 reductase, ABCB1, constitutive androstane receptor (CAR), pregnane X receptor (PXR)) were not substantially altered.
Neg (not) Regulation (altered) of constitutive androstane receptor in CAR
2) Confidence 0.21 Published 2007 Journal Clin. Pharmacol. Ther. Section Abstract Doc Link 17344806 Disease Relevance 0 Pain Relevance 0.07

General Comments

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