INT97468

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Context Info
Confidence 0.26
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.87
Pain Relevance 0.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

enzyme binding (DNM2) GTPase activity (DNM2) cytoplasm (DNM2)
cytosol (DNM2) signal transduction (DNM2) nucleus (DNM2)
DNM2 (Homo sapiens)
Pain Link Frequency Relevance Heat
COX-2 inhibitor 1 75.00 Quite High
cINOD 2 65.92 Quite High
COX2 1 25.00 Low Low
imagery 4 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
cva 2 5.00 Very Low Very Low Very Low
headache 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 2 100.00 Very High Very High Very High
Infection 168 99.08 Very High Very High Very High
Targeted Disruption 8 96.96 Very High Very High Very High
Carcinoma 1 92.88 High High
Adhesions 3 88.88 High High
Colon Cancer 3 75.00 Quite High
INFLAMMATION 1 65.36 Quite High
Dengue 22 50.00 Quite Low
Dengue Hemorrhagic Fever 18 5.00 Very Low Very Low Very Low
Fever 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We identified additional genes which are involved in different signaling pathways which regulate programmed cell death (Dynamin 2, Pdcd4 and LIP.1).
Regulation (regulate) of Dynamin 2 associated with apoptosis
1) Confidence 0.26 Published 2001 Journal Oncogene Section Abstract Doc Link 11494140 Disease Relevance 0.65 Pain Relevance 0.17
The knock-down of ATP6V0A1 and CLTC (at concentration of 50 nM) produced the strongest inhibition of DENV infection. siRNA smart pool-based deconvolution assays targeting CLTC, AP2B1, DNM2, ARRB1, ATP6V0A1 and ARPC1B were also performed to ensure that inhibitory effects on DENV infection observed in the primary screen was specific and not due to off-target gene effects of the siRNA primary screen. 30 nM of each specific individual siRNA of the smart pool (4 specific siRNAs) directed against each of the respective genes were reverse transfected into RD cells and subsequently subjected to DENV infection.
Regulation (targeting) of DNM2 associated with targeted disruption and infection
2) Confidence 0.19 Published 2010 Journal Virol J Section Body Doc Link PMC2825209 Disease Relevance 0.72 Pain Relevance 0
Reverse-transfection of Huh 7 cells with siRNAs targeting CLTC, AP2B1, DNM2, ARRB1, ATP6V0A1 and ARPC1B showed dosage dependent reductions in the levels of the respective proteins when compared to the levels in the mock-transfected cells (Figure 3).
Regulation (targeting) of DNM2
3) Confidence 0.19 Published 2010 Journal Virol J Section Body Doc Link PMC2825209 Disease Relevance 0.50 Pain Relevance 0

General Comments

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