INT97473

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Context Info
Confidence 0.34
First Reported 2001
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.72
Pain Relevance 0.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (FAP) extracellular space (FAP) plasma membrane (FAP)
Anatomy Link Frequency
germline 1
epithelium 1
FAP (Homo sapiens)
Pain Link Frequency Relevance Heat
Anterior cingulate cortex 81 88.16 High High
Action potential 9 71.92 Quite High
antagonist 8 65.96 Quite High
Glutamate receptor 3 65.52 Quite High
conotoxin 3 61.20 Quite High
Anterior cingulate 1 50.00 Quite Low
depression 10 13.60 Low Low
COX2 2 10.00 Low Low
cOX1 1 10.00 Low Low
Thalamus 30 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Familial Adenomatous Polyposis 54 100.00 Very High Very High Very High
Adenoma 33 95.28 Very High Very High Very High
Polyps 35 91.76 High High
Cancer 183 88.08 High High
Adenomatous Polyps 6 85.52 High High
Colorectal Cancer 50 73.24 Quite High
Intestinal Polyposis 1 63.56 Quite High
Syndrome 44 60.12 Quite High
Disease 46 55.84 Quite High
INFLAMMATION 4 54.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
One of the first alleged CFS families was later shown to have an attenuated variant of FAP.44
Positive_regulation (variant) of FAP associated with familial adenomatous polyposis
1) Confidence 0.34 Published 2006 Journal Medical History Section Body Doc Link PMC1483189 Disease Relevance 0.59 Pain Relevance 0
FAP is caused by germline mutations in the APC (adenomatous polyposis coli) gene.
Positive_regulation (caused) of FAP in germline associated with familial adenomatous polyposis
2) Confidence 0.20 Published 2008 Journal Current Genomics Section Body Doc Link PMC2674304 Disease Relevance 2.02 Pain Relevance 0
These findings suggest that the first fAP was directly activated by stimulation without synaptic relay and the second fPSP resulted from postsynaptic excitation.
Positive_regulation (activated) of fAP
3) Confidence 0.17 Published 2009 Journal Mol Pain Section Body Doc Link PMC2745374 Disease Relevance 0 Pain Relevance 0.18
CONCLUSIONS: COX-2 expression is upregulated in the adenomatous epithelium of SAP and FAP, while the COX-1 isoform appears to be constitutively expressed at low levels in both neoplastic and non-neoplastic regions.
Positive_regulation (upregulated) of FAP in epithelium
4) Confidence 0.13 Published 2001 Journal Scand. J. Gastroenterol. Section Body Doc Link 11495083 Disease Relevance 0.11 Pain Relevance 0

General Comments

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