INT97474

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Context Info
Confidence 0.67
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 1.85
Pain Relevance 1.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (UCN2) extracellular space (UCN2) extracellular region (UCN2)
response to stress (UCN2)
Anatomy Link Frequency
teeth 1
UCN2 (Homo sapiens)
Pain Link Frequency Relevance Heat
intrathecal 6 99.84 Very High Very High Very High
antagonist 11 98.82 Very High Very High Very High
agonist 1 98.54 Very High Very High Very High
gABA 2 96.86 Very High Very High Very High
GABAergic 4 85.04 High High
Action potential 2 74.96 Quite High
central sensitization 1 72.32 Quite High
spinal dorsal horn 1 65.96 Quite High
Pain 1 53.92 Quite High
anesthesia 7 50.00 Quite Low
Disease Link Frequency Relevance Heat
Chronic Periodontitis 16 98.80 Very High Very High Very High
Periodontal Pocket 3 94.52 High High
Overactive Bladder 2 91.04 High High
Stress Incontinence 12 87.20 High High
Periodontitis 25 84.40 Quite High
Pre-eclampsia 2 72.68 Quite High
Attention Deficit Hyperactivity Disorder 1 66.80 Quite High
Mouth Disease 6 54.08 Quite High
Injury 7 44.72 Quite Low
Xerostomia 1 24.48 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although there is, so far, no NR2A- and NR2B-specific agonist available, N-methyl-d-aspartate (NMDA) reversed the abolition on the RS-induced SRP caused by the co-administration of OxA and Co-101244 (30 nM, 10 mul; an NMDA NR2B subunit antagonist), but it did not reverse the abolition by the co-administration of OxA and PPPA (300 nM, 10 mul; an NMDA NR2A subunit antagonist).
Positive_regulation (induced) of SRP associated with antagonist and agonist
1) Confidence 0.67 Published 2008 Journal Am. J. Physiol. Endocrinol. Metab. Section Abstract Doc Link 18477704 Disease Relevance 0.21 Pain Relevance 0.40
Acute anal stretch using a mosquito clamp with a distance of 4 mm exhibited no effect, whereas distances of 8 mm attenuated and 12 mm abolished the repetitive stimulation-induced SRP.
Positive_regulation (induced) of SRP
2) Confidence 0.67 Published 2008 Journal Am. J. Physiol. Renal Physiol. Section Abstract Doc Link 18632795 Disease Relevance 0.33 Pain Relevance 0.41
METHODS: One hundred twenty-two (122) patients in 8 centers with moderate to severe periodontitis requiring scaling and root planing (SRP) were enrolled in this multicenter, randomized, double-blind, controlled clinical trial.
Positive_regulation (requiring) of SRP
3) Confidence 0.49 Published 2001 Journal J. Periodontol. Section Body Doc Link 11495138 Disease Relevance 0.09 Pain Relevance 0
After all teeth in the test quadrant had received SRP, the overall pain was assessed by the patient using a 100 mm horizontal, ungraded visual analog scale in which the left side was marked "no pain" and the right side marked "worst pain imaginable.
Positive_regulation (received) of SRP in teeth
4) Confidence 0.49 Published 2001 Journal J. Periodontol. Section Body Doc Link 11495138 Disease Relevance 0.07 Pain Relevance 0
On the other hand, pretreated bicuculline [gamma-aminobutyric acid (GABA) A receptor antagonist, 100 microM, 10 microl] but not hydroxysaclofen (GABAB receptor antagonist) counteracted the abolition on the repetitive stimulation-induced SRP caused by the anal stretch.
Positive_regulation (induced) of SRP associated with gaba and antagonist
5) Confidence 0.49 Published 2008 Journal Am. J. Physiol. Renal Physiol. Section Abstract Doc Link 18632795 Disease Relevance 0.36 Pain Relevance 0.41
The TAS level of the control group increased 3 months after SRP, but the level in the severe chronic periodontitis patients had not changed after 3 months.
Positive_regulation (increased) of SRP associated with chronic periodontitis
6) Confidence 0.02 Published 2010 Journal Journal of Periodontal & Implant Science Section Body Doc Link PMC2931304 Disease Relevance 0.78 Pain Relevance 0

General Comments

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