INT9748

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Context Info
Confidence 0.35
First Reported 1984
Last Reported 2005
Negated 1
Speculated 0
Reported most in Abstract
Documents 28
Total Number 28
Disease Relevance 8.93
Pain Relevance 3.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
blood 16
SDBP 2
chest 1
bladder 1
pulmonary artery 1
Sysbp1 (Mus musculus)
Pain Link Frequency Relevance Heat
cva 18 100.00 Very High Very High Very High
halothane 7 99.92 Very High Very High Very High
anesthesia 29 98.82 Very High Very High Very High
Thoracotomy 3 98.60 Very High Very High Very High
Dynorphin 1 97.32 Very High Very High Very High
Eae 1 95.08 Very High Very High Very High
antagonist 6 93.96 High High
Clonidine 4 93.28 High High
withdrawal 2 92.16 High High
ketamine 6 91.12 High High
Disease Link Frequency Relevance Heat
Cv General 3 Under Development 22 100.00 Very High Very High Very High
Pressure Volume 2 Under Development 22 100.00 Very High Very High Very High
Ventricular Heart Septal Defects 7 99.98 Very High Very High Very High
Hypertension 30 98.16 Very High Very High Very High
Coronary Artery Disease 8 96.32 Very High Very High Very High
Natriuresis 2 95.44 Very High Very High Very High
Cv General 4 Under Development 3 94.92 High High
Myocardial Infarction 13 91.92 High High
Peripheral Arterial Disease 4 89.08 High High
Diuresis 1 87.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Significant decreases from baseline supine diastolic blood pressure (SDBP) were observed in both groups at the end of the single-therapy phase (11 mm Hg in SDBP for betaxolol and 12 mm Hg in SDBP for chlorthalidone); a further significant decrease (7 mm Hg for betaxolol and 8 mm Hg for chlorthalidone in SDBP) was observed from the end of the single-therapy phase to the end of the combination-therapy phase.
Negative_regulation (decreases) of diastolic blood pressure in SDBP
1) Confidence 0.35 Published 1989 Journal Arch. Intern. Med. Section Abstract Doc Link 2684073 Disease Relevance 0.09 Pain Relevance 0
The mean decrease in supine diastolic blood pressure (SDBP) was 16 mmHg in groups 1 and 2; the mean decrease in supine systolic blood pressure (SSBP) was 19 mmHg in group 1 and 20 mmHg in group 2.
Negative_regulation (decrease) of supine diastolic blood pressure in SDBP
2) Confidence 0.34 Published 1993 Journal Clin Ther Section Abstract Doc Link 8519044 Disease Relevance 0.22 Pain Relevance 0
The normal decline in systolic blood pressure (SBP) during the recovery phase of treadmill exercise does not occur in some patients with coronary artery disease (CAD).
Negative_regulation (decline) of systolic blood pressure in coronary artery associated with coronary artery disease
3) Confidence 0.09 Published 1984 Journal Circulation Section Abstract Doc Link 6149824 Disease Relevance 0.27 Pain Relevance 0
A recent 8-week, double-masked, placebo-controlled, 3 x 4 factorial-design study demonstrated that enalapril-felodipine extended-release (ER) combinations had statistically significant additive effects for reducing both sitting systolic blood pressure (SiSBP) and sitting diastolic blood pressure (SiDBP) and were generally well tolerated in hypertensive patients with SiDBPs ranging from 95 to 115 mm Hg.
Negative_regulation (reducing) of sitting systolic blood pressure in blood associated with hypertension
4) Confidence 0.07 Published 1998 Journal Clin Ther Section Abstract Doc Link 9663368 Disease Relevance 0.17 Pain Relevance 0
A recent 8-week, double-masked, placebo-controlled, 3 x 4 factorial-design study demonstrated that enalapril-felodipine extended-release (ER) combinations had statistically significant additive effects for reducing both sitting systolic blood pressure (SiSBP) and sitting diastolic blood pressure (SiDBP) and were generally well tolerated in hypertensive patients with SiDBPs ranging from 95 to 115 mm Hg.
Negative_regulation (reducing) of sitting diastolic blood pressure in blood associated with hypertension
5) Confidence 0.07 Published 1998 Journal Clin Ther Section Abstract Doc Link 9663368 Disease Relevance 0.17 Pain Relevance 0
The induction and maintenance of anesthesia using this technique were almost satisfactory with little decrease in systolic blood pressure (SBP), although six patients among the early 21 patients developed hypotension below 90 mmHg (SBP) during the induction, and required vasopressors.
Neg (little) Negative_regulation (decrease) of systolic blood pressure in blood associated with anesthesia and pressure volume 2 under development
6) Confidence 0.05 Published 1992 Journal Masui Section Abstract Doc Link 1433880 Disease Relevance 0.63 Pain Relevance 0.68
With the rate of administration of 1.0 to 3.0 micrograms.kg-1.min-1, a significant decrease in systolic blood pressure (SBP) was observed compared with the pretreatment level of SBP.
Negative_regulation (decrease) of systolic blood pressure in blood associated with pressure volume 2 under development
7) Confidence 0.05 Published 1994 Journal Masui Section Abstract Doc Link 7815710 Disease Relevance 0.46 Pain Relevance 0.22
When used in these dosages, torasemide lowered diastolic blood pressure (DBP) to below 90mm Hg in 8 to 12 weeks in 70 to 80% of patients.
Negative_regulation (lowered) of diastolic blood pressure in blood
8) Confidence 0.04 Published 1996 Journal Drug Saf Section Abstract Doc Link 8852525 Disease Relevance 1.17 Pain Relevance 0.09
Both treatments induced a similar significant reduction in systolic blood pressure (SBP) and DBP, allowing normalization of BP in 58% of subjects on cadralazine and 55% on prazosin.
Negative_regulation (reduction) of systolic blood pressure in blood
9) Confidence 0.03 Published 1991 Journal Eur. J. Clin. Pharmacol. Section Abstract Doc Link 1679390 Disease Relevance 0.45 Pain Relevance 0.11
Mean arterial blood pressure (MBP) and SBP were significantly decreased during induction and after intubation in patients receiving sufentanil, but not fentanyl.
Negative_regulation (decreased) of Mean arterial blood pressure in blood
10) Confidence 0.01 Published 1988 Journal J Cardiothorac Anesth Section Abstract Doc Link 2980954 Disease Relevance 0.12 Pain Relevance 0.07
Maternal blood pressure (MBP) decreased from 114 +/- 9 to a nadir of 69 +/- 8 mmHg at 15 min post infusion.
Negative_regulation (decreased) of Maternal blood pressure in blood
11) Confidence 0.01 Published 1984 Journal Biol Res Pregnancy Perinatol Section Abstract Doc Link 6322873 Disease Relevance 0.16 Pain Relevance 0.08
A significant decrease in ICG clearance occurred in the patients who received only halothane to reduce the systolic arterial pressure (SAP) to 70% of the preoperative value.
Negative_regulation (reduce) of systolic arterial pressure associated with halothane
12) Confidence 0.01 Published 1990 Journal Masui Section Abstract Doc Link 2384953 Disease Relevance 0 Pain Relevance 0.41
In the AC and AC+LA groups we observed on minute 1 a decrease of the mean blood pressure (MBP) and of the systemic vascular resistances (SVR).
Negative_regulation (decrease) of mean blood pressure in SVR
13) Confidence 0.01 Published 1994 Journal Kidney Int. Section Abstract Doc Link 7861713 Disease Relevance 0.16 Pain Relevance 0.09
Bunazosin 1, 10 and 100 micrograms/kg i.v. dose-dependently decreased aortic blood pressure (AoP) and inhibited the increase in AoP by phenylephrine 5 micrograms/kg i.v.
Negative_regulation (decreased) of aortic blood pressure in blood
14) Confidence 0.01 Published 1986 Journal Arzneimittelforschung Section Abstract Doc Link 2877674 Disease Relevance 0.08 Pain Relevance 0
However, the concomitant administration of HCTZ 12.5 or 25 mg with losartan 50 mg resulted in significantly different (p < or = 0.05) reductions in diastolic blood pressure compared to the losartan/placebo group (diff. between groups = -4 (95% C.I. [-6.3, -1.1] mmHg) for 12.5mg combination group; -6 (95% C.I. [-8.3, -3.3]) mmHg for the HCTZ 25 mg combination group).
Negative_regulation (reductions) of diastolic blood pressure in blood
15) Confidence 0.01 Published 1996 Journal Blood Press. Section Abstract Doc Link 8777471 Disease Relevance 0.22 Pain Relevance 0
Stump pressure decreased in all negative cases after balloon inflation and than tended to increase progressively during 15 minutes of BTO.
Negative_regulation (decreased) of Stump pressure
16) Confidence 0.00 Published 1999 Journal J Neuroimaging Section Abstract Doc Link 10436757 Disease Relevance 0.23 Pain Relevance 0.08
Isradipine 5 micrograms/kg i.v. produced significant decreases in systolic, diastolic and mean aortic blood pressure (AoP) concomitant with a decrease in mean renal blood flow (RBF) and increases in mean vertebral blood flow (VBF), mean coronary blood flow (CBF) and left ventricular dP/dt (LVdP/dt), but almost unchanged heart rate (HR) and left ventricular enddiastolic pressure (LVEDP).
Negative_regulation (decreases) of aortic blood pressure in blood
17) Confidence 0.00 Published 1988 Journal Arzneimittelforschung Section Abstract Doc Link 2977545 Disease Relevance 0 Pain Relevance 0.08
Intravenous infusion of KB-2796 (10, 30, and 100 micrograms/kg/min) decreased mean blood pressure (MBP) and renal vascular resistance (RVR) in a dose-dependent manner, but did not change renal blood flow (RBF).
Negative_regulation (decreased) of mean blood pressure in blood
18) Confidence 0.00 Published 1992 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 1434110 Disease Relevance 0 Pain Relevance 0.08
After the treatment, mean blood pressure (MBP), heart rate and 24 h urine norepinephrine, epinephrine were decreased, but no change was found in plasma Dyn A.
Negative_regulation (decreased) of mean blood pressure in urine
19) Confidence 0.00 Published 1993 Journal Zhongguo Yao Li Xue Bao Section Abstract Doc Link 7901963 Disease Relevance 0.26 Pain Relevance 0.43
In open-chest anesthetized dogs, NIC (0.1-10 micrograms/kg/min i.v.) dose-dependently increased cardiac output (CO) and coronary blood flow as well as decreased mean blood pressure (MBP).
Negative_regulation (decreased) of mean blood pressure in chest
20) Confidence 0.00 Published 1998 Journal Arzneimittelforschung Section Abstract Doc Link 9541721 Disease Relevance 0.59 Pain Relevance 0.08

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