INT9750

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Context Info
Confidence 0.66
First Reported 1984
Last Reported 2009
Negated 0
Speculated 1
Reported most in Abstract
Documents 39
Total Number 40
Disease Relevance 12.44
Pain Relevance 15.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Rara) nucleus (Rara) enzyme binding (Rara)
DNA binding (Rara) transcription factor binding (Rara) cytoplasm (Rara)
Anatomy Link Frequency
lung 8
nerve 3
respiratory 2
peripheral nervous system 1
dorsal root ganglia 1
Rara (Mus musculus)
Pain Link Frequency Relevance Heat
c fibre 99 100.00 Very High Very High Very High
qutenza 49 99.78 Very High Very High Very High
Inflammation 240 99.70 Very High Very High Very High
agonist 41 99.48 Very High Very High Very High
Action potential 12 99.40 Very High Very High Very High
Spinal cord 160 99.36 Very High Very High Very High
Peripheral nervous system 30 99.12 Very High Very High Very High
substance P 22 99.10 Very High Very High Very High
Adelta 3 98.40 Very High Very High Very High
antagonist 14 98.28 Very High Very High Very High
Disease Link Frequency Relevance Heat
Injury 102 99.90 Very High Very High Very High
Heart Rate Under Development 6 99.88 Very High Very High Very High
INFLAMMATION 316 99.70 Very High Very High Very High
Cough 25 99.66 Very High Very High Very High
Necrosis 4 99.24 Very High Very High Very High
Diuresis 12 98.96 Very High Very High Very High
Rheumatoid Arthritis 280 98.64 Very High Very High Very High
Pressure And Volume Under Development 9 97.08 Very High Very High Very High
Immunotherapy Of Cancer 5 96.04 Very High Very High Very High
Myocardial Infarction 16 95.04 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Rapidly adapting receptors (RAR) in the lung are stimulated when the lung compliance is reduced.
Positive_regulation (stimulated) of RAR in lung
1) Confidence 0.66 Published 2003 Journal Respir Physiol Neurobiol Section Abstract Doc Link 14609507 Disease Relevance 0 Pain Relevance 0.36
Small acute increases in extravascular fluid volume in the airways activate the RAR.
Positive_regulation (activate) of RAR
2) Confidence 0.65 Published 2009 Journal Respir Physiol Neurobiol Section Abstract Doc Link 18977461 Disease Relevance 0.57 Pain Relevance 0.10
Activation of RAR causes a reflex increase in respiratory rate, tracheal tone and mucus secretion from the airways.
Positive_regulation (Activation) of RAR in respiratory
3) Confidence 0.65 Published 2009 Journal Respir Physiol Neurobiol Section Abstract Doc Link 18977461 Disease Relevance 0.55 Pain Relevance 0.10
In contrast, when left atrial pressure is elevated chronically, further small increments in extravascular fluid volume of the airways no longer stimulate the RAR.
Positive_regulation (stimulate) of RAR
4) Confidence 0.62 Published 2008 Journal Indian J Chest Dis Allied Sci Section Abstract Doc Link 18610686 Disease Relevance 0.39 Pain Relevance 0.17
Activation of RAR causes a reflex increase in respiratory rate, tracheal tone and mucus secretion from the airways.
Positive_regulation (Activation) of RAR in respiratory
5) Confidence 0.62 Published 2008 Journal Indian J Chest Dis Allied Sci Section Abstract Doc Link 18610686 Disease Relevance 0.39 Pain Relevance 0.18
Small acute increases (< 10 mmHg) in left atrial pressure enhance the extravascular fluid volume in the airways and activate the rapidly adapting receptors (RAR).
Positive_regulation (activate) of RAR
6) Confidence 0.62 Published 2008 Journal Indian J Chest Dis Allied Sci Section Abstract Doc Link 18610686 Disease Relevance 0.33 Pain Relevance 0.16
The present investigation was undertaken to determine whether bronchial C-fibers are also activated when lung compliance is decreased since both RAR and bronchial C-fibers are influenced by extra-vascular fluid in the airways.
Positive_regulation (influenced) of RAR in lung associated with c fibre
7) Confidence 0.48 Published 2003 Journal Respir Physiol Neurobiol Section Abstract Doc Link 14609507 Disease Relevance 0 Pain Relevance 0.46
induced RAR?
Positive_regulation (induced) of RAR
8) Confidence 0.45 Published 2007 Journal PPAR Research Section Body Doc Link PMC1950239 Disease Relevance 0.24 Pain Relevance 0.37
enzyme RALDH in dorsal root ganglia [23] and activated the RAR?
Positive_regulation (activated) of RAR in dorsal root ganglia
9) Confidence 0.45 Published 2007 Journal PPAR Research Section Body Doc Link PMC1950239 Disease Relevance 1.11 Pain Relevance 0.15
Both RAR and bronchial C-fiber activity increased significantly compared with control when lung compliance was decreased (bronchial C-fibers: 35 +/- 5 vs. 66 +/- 13 impulses per 30 sec and RAR: 3 +/- 1 vs. 94 +/- 14 impulses per 30 sec).
Positive_regulation (increased) of RAR in lung associated with c fibre
10) Confidence 0.44 Published 2003 Journal Respir Physiol Neurobiol Section Abstract Doc Link 14609507 Disease Relevance 0 Pain Relevance 0.55
With larger increases both the RAR and the C-fiber receptors in the airways and the alveoli are activated.
Positive_regulation (activated) of RAR associated with c fibre
11) Confidence 0.44 Published 2009 Journal Respir Physiol Neurobiol Section Abstract Doc Link 18977461 Disease Relevance 0.56 Pain Relevance 0.10
With larger increases both the RAR and the C-fiber receptors in the airways and the alveoli are activated.
Positive_regulation (increases) of RAR associated with c fibre
12) Confidence 0.44 Published 2009 Journal Respir Physiol Neurobiol Section Abstract Doc Link 18977461 Disease Relevance 0.57 Pain Relevance 0.10
However, the RAR continue to be activated by increments in left atrial pressure in excess of 25 mmHg.
Positive_regulation (activated) of RAR
13) Confidence 0.41 Published 2008 Journal Indian J Chest Dis Allied Sci Section Abstract Doc Link 18610686 Disease Relevance 0.38 Pain Relevance 0.17
With larger increases in left atrial pressure (approximately 25 mmHg) both the RAR and the C-fiber receptors in the airways and the alveoli are activated.
Positive_regulation (activated) of RAR associated with c fibre
14) Confidence 0.41 Published 2008 Journal Indian J Chest Dis Allied Sci Section Abstract Doc Link 18610686 Disease Relevance 0.39 Pain Relevance 0.18
With larger increases in left atrial pressure (approximately 25 mmHg) both the RAR and the C-fiber receptors in the airways and the alveoli are activated.
Positive_regulation (increases) of RAR associated with c fibre
15) Confidence 0.41 Published 2008 Journal Indian J Chest Dis Allied Sci Section Abstract Doc Link 18610686 Disease Relevance 0.39 Pain Relevance 0.17
Five slowly adapting receptors and two RARs were also challenged with topically applied capsaicin; only one RAR was stimulated.
Positive_regulation (stimulated) of RAR associated with qutenza
16) Confidence 0.41 Published 1999 Journal J. Appl. Physiol. Section Abstract Doc Link 10194208 Disease Relevance 0.09 Pain Relevance 0.13
Right atrial administration of SP (0.3, 1.0, and 3.0 micrograms/kg) caused an increase in the RAR activity, and this increase became more prominent as the dose of SP was increased.
Positive_regulation (increase) of RAR associated with substance p
17) Confidence 0.38 Published 1994 Journal Lung Section Abstract Doc Link 7507541 Disease Relevance 0 Pain Relevance 0.49
Selective C-fiber blockade abolished histamine-induced increases in RAR activity while only partially attenuating reductions in lung compliance.
Positive_regulation (increases) of RAR in lung associated with c fibre
18) Confidence 0.37 Published 2000 Journal Lung Section Abstract Doc Link 10723719 Disease Relevance 0 Pain Relevance 0.35
We conclude that the increase in RAR activity induced by histamine depends on intact C-fibers and not on a direct effect of histamine on RARs or an indirect effect of histamine reducing lung compliance.
Positive_regulation (increase) of RAR in lung associated with c fibre
19) Confidence 0.37 Published 2000 Journal Lung Section Abstract Doc Link 10723719 Disease Relevance 0 Pain Relevance 0.34
Manipulation of RAR/RXR signaling in the peripheral nervous system
Positive_regulation (Manipulation) of RAR in peripheral nervous system associated with peripheral nervous system
20) Confidence 0.32 Published 2007 Journal PPAR Research Section Body Doc Link PMC1950239 Disease Relevance 0.46 Pain Relevance 0.32

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