INT9751

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Context Info
Confidence 0.78
First Reported 1989
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 26
Total Number 26
Disease Relevance 10.47
Pain Relevance 15.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Crhr1) response to stress (Crhr1) signal transducer activity (Crhr1)
Anatomy Link Frequency
hypothalamus 2
forelimb 2
face 2
plasma 1
amygdala 1
Crhr1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
anesthesia 15 100.00 Very High Very High Very High
lidocaine 28 99.92 Very High Very High Very High
antagonist 24 99.92 Very High Very High Very High
cocaine 24 99.82 Very High Very High Very High
cytokine 4 99.60 Very High Very High Very High
halothane 6 99.48 Very High Very High Very High
tetrodotoxin 19 99.42 Very High Very High Very High
Eae 12 99.42 Very High Very High Very High
gABA 7 99.40 Very High Very High Very High
Calcitonin gene-related peptide 1 99.22 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 95 99.44 Very High Very High Very High
Injury 11 99.42 Very High Very High Very High
Nociception 37 99.36 Very High Very High Very High
Urological Neuroanatomy 8 99.04 Very High Very High Very High
Body Weight 5 97.80 Very High Very High Very High
Increased Venous Pressure Under Development 4 97.80 Very High Very High Very High
Pressure And Volume Under Development 3 97.60 Very High Very High Very High
Anxiety Disorder 96 97.46 Very High Very High Very High
Pain 127 97.26 Very High Very High Very High
Targeted Disruption 2 95.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These interactions may result from biochemical changes related to the physiological stress response, as, for example, the release of corticotrophin releasing hormone, or from changes induced by the psychological response to stressors.
Localization (release) of corticotrophin releasing hormone associated with stress
1) Confidence 0.78 Published 2009 Journal Headache Section Abstract Doc Link 19619238 Disease Relevance 1.22 Pain Relevance 0.71
The effects of noxious and non-noxious mechanical stimulation of various segmental skin areas (face, forelimb and forepaw, abdomen, hindlimb and hindpaw) on the secretion of immunoreactive corticotropin-releasing hormone (iCRH) from the hypothalamus into hypophysial portal blood was examined in artificially ventilated rats under halothane anesthesia.
Localization (secretion) of iCRH in face associated with anesthesia and halothane
2) Confidence 0.78 Published 1992 Journal Jpn. J. Physiol. Section Abstract Doc Link 1434108 Disease Relevance 0 Pain Relevance 0.14
The effects of noxious and non-noxious mechanical stimulation of various segmental skin areas (face, forelimb and forepaw, abdomen, hindlimb and hindpaw) on the secretion of immunoreactive corticotropin-releasing hormone (iCRH) from the hypothalamus into hypophysial portal blood was examined in artificially ventilated rats under halothane anesthesia.
Localization (secretion) of immunoreactive corticotropin-releasing hormone in face associated with anesthesia and halothane
3) Confidence 0.78 Published 1992 Journal Jpn. J. Physiol. Section Abstract Doc Link 1434108 Disease Relevance 0 Pain Relevance 0.14
Differential responsivity of the hypothalamic-pituitary-adrenal axis to glucocorticoid negative-feedback and corticotropin releasing hormone in rats undergoing morphine withdrawal: possible mechanisms involved in facilitated and attenuated stress responses.
Localization (releasing) of corticotropin releasing hormone in pituitary associated with stress, withdrawal and morphine
4) Confidence 0.73 Published 2001 Journal J. Neuroendocrinol. Section Title Doc Link 11679056 Disease Relevance 0.25 Pain Relevance 0.69
CCI increased the expression of corticotrophin releasing hormone mRNA in the central amygdala, and not the paraventricular nucleus of the hypothalamus or the bed nucleus of the stria terminalis.
Localization (releasing) of corticotrophin releasing hormone in amygdala associated with eae and amygdala
5) Confidence 0.72 Published 2006 Journal Physiol. Behav. Section Abstract Doc Link 16647726 Disease Relevance 1.94 Pain Relevance 1.47
Secretion of iCRH was calculated from the iCRH concentration in hypophysial portal plasma and the plasma flow rate.
Localization (Secretion) of iCRH in plasma
6) Confidence 0.68 Published 1992 Journal Jpn. J. Physiol. Section Abstract Doc Link 1434108 Disease Relevance 0 Pain Relevance 0.15
Pinching of the bilateral forepaws or hindpaws and brushing of the bilateral hindlimbs for 20 min increased hypothalamic iCRH secretion.
Localization (secretion) of iCRH in hindlimbs
7) Confidence 0.68 Published 1992 Journal Jpn. J. Physiol. Section Abstract Doc Link 1434108 Disease Relevance 0 Pain Relevance 0.12
The latter project either indirectly, via the medial preoptic area, or directly to the paraventricular nucleus to release corticotrophin releasing hormone (CRH) and arginine vasopressin (AVP).
Localization (release) of corticotrophin releasing hormone in medial associated with urological neuroanatomy
8) Confidence 0.53 Published 2003 Journal Reproduction Section Abstract Doc Link 12578529 Disease Relevance 0.87 Pain Relevance 0.54
Using in vitro incubation of the median basal hypothalamus (MBH) fragment we studied the hypothalamic corticotrophin-releasing hormone (CRH) release under basal conditions and under the inhibitory effect of ACTH.
Localization (release) of corticotrophin-releasing hormone in hypothalamus
9) Confidence 0.49 Published 1996 Journal Braz. J. Med. Biol. Res. Section Abstract Doc Link 9196563 Disease Relevance 0.09 Pain Relevance 0.09
For example, hypothalamic corticotrophin-releasing hormone (CRH) that is released during such activation has been attributed with analgesic actions.
Localization (released) of corticotrophin-releasing hormone associated with analgesic
10) Confidence 0.47 Published 2004 Journal Prog. Neuropsychopharmacol. Biol. Psychiatry Section Abstract Doc Link 15276687 Disease Relevance 0.54 Pain Relevance 0.73
NMU has also been reported to participate in several physiological functions including release of corticotrophin releasing hormone, excitation of nociceptive neurons, and regulation of body weight [62], [63].
Localization (release) of corticotrophin releasing hormone in body associated with nociception and body weight
11) Confidence 0.34 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001483 Disease Relevance 0.20 Pain Relevance 0.44
Pain-related PKA activation in the CeLC appears to occur downstream of calcitonin gene-related peptide receptor CGRP1 [10] and corticotropin-releasing factor receptor CRF1[11,33].
Localization (releasing) of CRF1 associated with pain, amygdala and calcitonin gene-related peptide
12) Confidence 0.30 Published 2008 Journal Mol Pain Section Body Doc Link PMC2490682 Disease Relevance 1.15 Pain Relevance 1.53
The effects of noxious and non-noxious mechanical stimulation of various segmental skin areas (face, forelimb and forepaw, abdomen, hindlimb and hindpaw) on the secretion of immunoreactive corticotropin-releasing hormone (iCRH) from the hypothalamus into hypophysial portal blood was examined in artificially ventilated rats under halothane anesthesia.
Localization (secretion) of immunoreactive corticotropin-releasing hormone in forelimb associated with anesthesia and halothane
13) Confidence 0.26 Published 1992 Journal Jpn. J. Physiol. Section Abstract Doc Link 1434108 Disease Relevance 0 Pain Relevance 0.14
The effects of noxious and non-noxious mechanical stimulation of various segmental skin areas (face, forelimb and forepaw, abdomen, hindlimb and hindpaw) on the secretion of immunoreactive corticotropin-releasing hormone (iCRH) from the hypothalamus into hypophysial portal blood was examined in artificially ventilated rats under halothane anesthesia.
Localization (secretion) of iCRH in forelimb associated with anesthesia and halothane
14) Confidence 0.26 Published 1992 Journal Jpn. J. Physiol. Section Abstract Doc Link 1434108 Disease Relevance 0 Pain Relevance 0.14
On the other hand, cocaine-induced iCRH secretion was inhibited by GABA, a potent inhibitor of CRH secretion, dexamethasone, verapamil, a calcium channel blocker, tetrodotoxin, a sodium channel blocker, and carbamazepine, an antiepileptic and antidepressive agent.
Localization (secretion) of iCRH associated with tetrodotoxin, gaba, calcium channel, sodium channel, dexamethasone, carbamazepine and cocaine
15) Confidence 0.23 Published 1989 Journal Brain Res. Section Abstract Doc Link 2611679 Disease Relevance 0 Pain Relevance 0.79
Isolated or simultaneous pharmacologic blockade of cholinergic (atropine plus hexamethonium), serotonergic (ritanserin), alpha-adrenergic (phentolamine) and/or dopaminergic (compound SCH 23390) receptor subtypes failed to inhibit cocaine-induced iCRH secretion.
Localization (secretion) of iCRH associated with cocaine
16) Confidence 0.23 Published 1989 Journal Brain Res. Section Abstract Doc Link 2611679 Disease Relevance 0 Pain Relevance 0.80
Cocaine stimulated iCRH secretion in a dose-dependent fashion with peak of activity at 10(-8) M.
Localization (secretion) of iCRH associated with cocaine
17) Confidence 0.20 Published 1989 Journal Brain Res. Section Abstract Doc Link 2611679 Disease Relevance 0 Pain Relevance 0.79
Corticotrophin releasing factor attenuates NG-nitro-L-arginine methyl ester induced increases in blood pressure in the anaesthetised rat.
Localization (releasing) of Corticotrophin in blood associated with pressure and volume under development and anesthesia
18) Confidence 0.20 Published 1999 Journal J Hum Hypertens Section Title Doc Link 10618682 Disease Relevance 0.19 Pain Relevance 0.10
In vitro corticotrophin releasing factor (CRF) causes a prolonged endothelium-dependent vasodilatation which is blocked by inhibitors of nitric oxide (NO) synthase (NOS).
Localization (releasing) of corticotrophin in endothelium associated with increased venous pressure under development
19) Confidence 0.20 Published 1999 Journal J Hum Hypertens Section Abstract Doc Link 10618682 Disease Relevance 0.17 Pain Relevance 0
In contrast to procaine and lidocaine, TTX inhibited rather than stimulated iCRH secretion.
Localization (secretion) of iCRH associated with tetrodotoxin and lidocaine
20) Confidence 0.15 Published 1990 Journal Horm. Metab. Res. Section Abstract Doc Link 1968416 Disease Relevance 0.14 Pain Relevance 1.09

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