INT97513

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Context Info
Confidence 0.71
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 8
Disease Relevance 8.14
Pain Relevance 1.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeleton (Mefv) nucleus (Mefv) intracellular (Mefv)
cytoplasm (Mefv)
Mefv (Mus musculus)
Pain Link Frequency Relevance Heat
Crohn's disease 246 98.56 Very High Very High Very High
abdominal pain 6 98.32 Very High Very High Very High
Arthritis 3 97.00 Very High Very High Very High
Opioid 1 90.36 High High
Inflammation 66 90.20 High High
cINOD 2 89.84 High High
rheumatoid arthritis 3 89.12 High High
Pain refractory 1 87.92 High High
Pain 2 73.28 Quite High
headache 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Fever 81 100.00 Very High Very High Very High
Inflammatory Bowel Disease 357 99.20 Very High Very High Very High
Serositis 2 98.92 Very High Very High Very High
Disease 291 98.56 Very High Very High Very High
Abdominal Pain 6 98.32 Very High Very High Very High
Recurrence 1 97.32 Very High Very High Very High
Juvenile Chronic Polyarthritis 3 97.00 Very High Very High Very High
Pressure And Volume Under Development 4 94.20 High High
INFLAMMATION 58 90.20 High High
Rheumatoid Arthritis 3 89.12 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This clinical and epidemiological evidence linking IBD to the MEFV gene, together with the co-localization of the MEFV and NLRP3 gene products (pyrin and NALP3, respectively) within the same signaling pathway, suggested that MEFV could also contribute to CD and/or UC susceptibility.
Localization (localization) of pyrin associated with inflammatory bowel disease and crohn's disease
1) Confidence 0.71 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2745755 Disease Relevance 1.85 Pain Relevance 0.17
Among these SNPs, three of them (i.e. rs224217, rs224225, rs224223) located in the MEFV 5?
Localization (located) of MEFV
2) Confidence 0.65 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2745755 Disease Relevance 1.18 Pain Relevance 0.16
flanking region of MEFV, was significantly associated with CD (p?
Localization (region) of MEFV associated with crohn's disease
3) Confidence 0.65 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2745755 Disease Relevance 0.91 Pain Relevance 0.26
Atypical presentations of FMF have been increasingly reported.
Localization (presentations) of FMF associated with fever
4) Confidence 0.65 Published 2010 Journal Rheumatol. Int. Section Abstract Doc Link 19466424 Disease Relevance 1.39 Pain Relevance 0.21
The aim of this paper is to report a patient with this distinctively unusual clinical presentation of FMF.
Localization (presentation) of FMF associated with fever
5) Confidence 0.61 Published 2006 Journal Clin. Rheumatol. Section Abstract Doc Link 16328089 Disease Relevance 0.99 Pain Relevance 0.54
The Mediterranean fever (MEFV) gene is localized on 16p13.3 and more than 35 mutations have been described to date.
Localization (localized) of MEFV associated with fever
6) Confidence 0.61 Published 2008 Journal Clin. Rheumatol. Section Abstract Doc Link 18000697 Disease Relevance 1.14 Pain Relevance 0.10
CONCLUSION: FMF in young children may begin with attacks of fever alone, but it progresses to typical FMF disease over the next 2.9 +/- 2.2 years.
Localization (disease) of FMF
7) Confidence 0.56 Published 2010 Journal J. Rheumatol. Section Body Doc Link 20194447 Disease Relevance 0 Pain Relevance 0
Immunofluorescence studies show that pyrin co-localizes with ASC in specks.
Localization (localizes) of pyrin
8) Confidence 0.13 Published 2001 Journal J. Biol. Chem. Section Abstract Doc Link 11498534 Disease Relevance 0.68 Pain Relevance 0.11

General Comments

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