INT97516

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Context Info
Confidence 0.36
First Reported 2001
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 46
Total Number 46
Disease Relevance 7.06
Pain Relevance 7.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PYCARD) signal transduction (PYCARD) intracellular (PYCARD)
cytoplasm (PYCARD)
Anatomy Link Frequency
brain 3
lung 1
head 1
cortex 1
vein 1
PYCARD (Homo sapiens)
Pain Link Frequency Relevance Heat
Transcranial magnetic stimulation 1971 100.00 Very High Very High Very High
imagery 106 100.00 Very High Very High Very High
antidepressant 32 100.00 Very High Very High Very High
agonist 400 98.92 Very High Very High Very High
beta blocker 20 97.28 Very High Very High Very High
poststroke pain 4 96.36 Very High Very High Very High
Inflammation 120 96.24 Very High Very High Very High
antagonist 10 96.04 Very High Very High Very High
headache 6 95.28 Very High Very High Very High
depression 109 94.56 High High
Disease Link Frequency Relevance Heat
Apoptosis 10 100.00 Very High Very High Very High
Convulsion 32 99.98 Very High Very High Very High
Epilepsy 42 99.28 Very High Very High Very High
Cognitive Disorder 86 97.50 Very High Very High Very High
Fever 117 97.12 Very High Very High Very High
Pain 69 96.36 Very High Very High Very High
INFLAMMATION 116 96.24 Very High Very High Very High
Stroke 70 96.16 Very High Very High Very High
Headache 12 95.28 Very High Very High Very High
Disease 216 94.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interaction between pyrin and the apoptotic speck protein (ASC) modulates ASC-induced apoptosis.
ASC Binding (Interaction) of associated with apoptosis
1) Confidence 0.36 Published 2001 Journal J. Biol. Chem. Section Title Doc Link 11498534 Disease Relevance 0.78 Pain Relevance 0.14
Investigating Connectivity with TMS Alone
TMS Binding (Investigating) of associated with transcranial magnetic stimulation
2) Confidence 0.32 Published 2010 Journal Frontiers in Systems Neuroscience Section Body Doc Link PMC2950743 Disease Relevance 0.38 Pain Relevance 0.24
One of the most exciting aspects of TMS is that brain activity in one region is directly induced and the propagation of that activity to other regions can thus provide information regarding causal interactions between areas.
TMS Binding (interactions) of in brain associated with transcranial magnetic stimulation
3) Confidence 0.32 Published 2010 Journal Frontiers in Systems Neuroscience Section Body Doc Link PMC2950743 Disease Relevance 0.06 Pain Relevance 0.38
Studies using TMS and imaging in separate sessions
TMS Binding (imaging) of associated with transcranial magnetic stimulation and imagery
4) Confidence 0.32 Published 2010 Journal Frontiers in Systems Neuroscience Section Body Doc Link PMC2950743 Disease Relevance 0.09 Pain Relevance 0.57
There is wide recognition that TMS is a powerful tool for studying and modulating connectivity in the human brain, but perhaps less awareness that connectivity mapping can be a useful tool for guiding TMS stimulation.
TMS Binding (recognition) of in brain associated with transcranial magnetic stimulation
5) Confidence 0.32 Published 2010 Journal Frontiers in Systems Neuroscience Section Body Doc Link PMC2950743 Disease Relevance 0.26 Pain Relevance 0.46
To control for this possibility, we also tested the same subjects but with rTMS targeted to brain regions beneath the vertex of the scalp, rather than the visual cortex (in counterbalanced order).
rTMS Binding (targeted) of in cortex
6) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2860988 Disease Relevance 0 Pain Relevance 0.20
Cowey et al. [31] found that online rTMS of both V5 and V2/V3 impaired direction of coherent motion discrimination but not detection of coherent motion.
rTMS Binding (online) of
7) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2860988 Disease Relevance 0 Pain Relevance 0.04
Targeting this seeded PPC and the connected MFG with TMS in distinct time windows resulted in time-specific behavioral effects for both brain regions.
TMS Binding (Targeting) of in brain associated with transcranial magnetic stimulation
8) Confidence 0.32 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2789405 Disease Relevance 0 Pain Relevance 0.43
The results in our experiments were similar, but it would be interesting to determine if the enhanced performance we have observed could be targeted by more specific stimulus conditions during rTMS.
rTMS Binding (targeted) of
9) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2860988 Disease Relevance 0 Pain Relevance 0.04
If, as in the traditional seesaw-rivalry theory, TMS disrupts perceptual processing in one hemisphere and enhances it in the other, we would expect that discrimination performance should again improve for the hand ipsilateral to TMS and so should presumably worsen for the hand contralateral to TMS.
TMS Binding (improve) of associated with transcranial magnetic stimulation
10) Confidence 0.30 Published 2010 Journal Neuropsychologia Section Body Doc Link PMC2956832 Disease Relevance 0 Pain Relevance 0.33
As in Experiment 1, they were told to ignore the TMS as far as possible.
TMS Binding (ignore) of associated with transcranial magnetic stimulation
11) Confidence 0.30 Published 2010 Journal Neuropsychologia Section Body Doc Link PMC2956832 Disease Relevance 0 Pain Relevance 0.33
Guided by neuroimaging studies, the prefrontal cortex was proposed as a suitable target for antidepressant rTMS (George et al 1995), and initial studies of focal rTMS of the left prefrontal cortex (PFC) seemed encouraging (Pascual-Leone et al 1996).
rTMS Binding (target) of in prefrontal associated with antidepressant
12) Confidence 0.30 Published 2006 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2671781 Disease Relevance 0.22 Pain Relevance 0.45
Unlike Experiment 1, there was no interaction between TMS intensity and the side of somatosensory stimulation [F(1,68) = 0.70, p = 0.41], indicating a similar outcome for both hands here.
TMS Neg (no) Binding (interaction) of associated with transcranial magnetic stimulation
13) Confidence 0.29 Published 2010 Journal Neuropsychologia Section Body Doc Link PMC2956832 Disease Relevance 0 Pain Relevance 0.28
Within 5 minutes of the completion of the rTMS, 10mCi of [11C]FLB 457 were injected into the left antecubital vein over 60 seconds and 31 frames of dynamic scanning were acquired over 90 min [30].
rTMS Binding (completion) of in vein
14) Confidence 0.28 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2725302 Disease Relevance 0 Pain Relevance 0.31
Comparing Standard and Reversed TMS (Fig. 3), the motor threshold was higher for Reversed TMS (Fig8 coil: mean difference?
TMS Binding (Comparing) of associated with transcranial magnetic stimulation
15) Confidence 0.25 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2271126 Disease Relevance 0 Pain Relevance 0.44
Whenever TMS was applied to the subjects, in addition to continuing to perform the Stroop task, subjects were also instructed to press key 1 if they thought that they received real TMS (Standard or Reversed TMS) and 2 if they thought they received Sham TMS.
TMS Binding (received) of associated with transcranial magnetic stimulation
16) Confidence 0.25 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2271126 Disease Relevance 0 Pain Relevance 0.67
We chose this study design because in most TMS studies, subjects perform a cognitive task while they receive TMS, and we wanted to test whether subjects can discriminate whether they received Standard or sham TMS applied to the top of the head (Cz according to the International 10–20 Electroencephalogram (EEG) system) under these conditions.
TMS Binding (applied) of in head associated with cognitive disorder and transcranial magnetic stimulation
17) Confidence 0.25 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2271126 Disease Relevance 0.26 Pain Relevance 0.26
In fact, only by integrating TMS/hd-EEG with high resolution structural imaging techniques, such as diffusion tensor imaging (DTI), one may be able to control, in any cortical area, the coil's orientation with respect to the main direction of axons.
TMS Binding (integrating) of associated with transcranial magnetic stimulation and imagery
18) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2858649 Disease Relevance 0.08 Pain Relevance 0.35
However, direct cortical stimulation of SMA has previously induced movements [6], so an alternative explanation could be that we were not able to efficiently stimulate SMA with TMS when the TMS was not accompanied by a voluntary effort, as was the case for the study by Haggard and Whitford [2].
TMS Binding (accompanied) of
19) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2952623 Disease Relevance 0 Pain Relevance 0
Experiments involving the binding of Asc directly to isolated receptor preparations show that the lowest Asc concentration, 10 µM, produces an absorbance change at 220–230 nm (Figure 10).
Asc Binding (binding) of
20) Confidence 0.22 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001466 Disease Relevance 0.31 Pain Relevance 0.17

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