INT97519

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Context Info
Confidence 0.27
First Reported 2001
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 1.92
Pain Relevance 0.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (WRN) aging (WRN) intracellular (WRN)
helicase activity (WRN) DNA binding (WRN) nucleolus (WRN)
WRN (Homo sapiens)
Pain Link Frequency Relevance Heat
lumbar spondylosis 1 95.24 Very High Very High Very High
Osteoarthritis 1 92.44 High High
Restless leg syndrome 1 5.00 Very Low Very Low Very Low
Angina 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Aging 71 100.00 Very High Very High Very High
Premature Aging 1 97.00 Very High Very High Very High
Low Back Pain 5 94.96 High High
Werner Syndrome 5 94.36 High High
Osteoarthritis 1 92.44 High High
Osteoporosis 2 91.68 High High
Death 29 88.64 High High
Syndrome 1 83.20 Quite High
Cockayne Syndrome 1 82.24 Quite High
Disease 3 16.36 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A longitudinal study of ageing Danish twins recently reported a possible association between a successful aging trait and 3 SNPs in the WRN gene [44].
WRN Binding (association) of associated with aging
1) Confidence 0.27 Published 2007 Journal BMC Med Genet Section Body Doc Link PMC1995604 Disease Relevance 1.15 Pain Relevance 0
We investigated the association of a WRN gene polymorphism, namely c.4330 T --> C leading to an amino acid substitution from Cys to Arg, with bone density and lumbar spondylosis score in unrelated Japanese postmenopausal women (n = 377).
WRN Binding (association) of associated with low back pain and lumbar spondylosis
2) Confidence 0.26 Published 2001 Journal J. Bone Miner. Metab. Section Abstract Doc Link 11498731 Disease Relevance 0.77 Pain Relevance 0.14

General Comments

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