INT97523

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Context Info
Confidence 0.46
First Reported 1999
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.59
Pain Relevance 2.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (NOS1) oxidoreductase activity (NOS1) cytoskeleton (NOS1)
cytoplasm (NOS1)
Anatomy Link Frequency
neuronal 1
brain 1
Brainstem 1
NOS1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Neuronal nitric oxide synthase 1 100.00 Very High Very High Very High
medulla 1 99.98 Very High Very High Very High
adenocard 2 99.04 Very High Very High Very High
Neurotransmitter 1 98.62 Very High Very High Very High
Clonidine 9 97.20 Very High Very High Very High
addiction 13 96.72 Very High Very High Very High
Morphine 20 96.28 Very High Very High Very High
opioid receptor 1 87.12 High High
cerebral cortex 4 84.16 Quite High
Rostral ventrolateral medulla 7 82.32 Quite High
Disease Link Frequency Relevance Heat
Hypotension 9 98.08 Very High Very High Very High
Morphine Dependence 2 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
NOS phosphorylation in some other brain regions, which may be regulated by PKA, probably contributes to the increase of NOS activity in morphine-dependent mice.
Phosphorylation (phosphorylation) of NOS in brain associated with morphine
1) Confidence 0.46 Published 1999 Journal Sheng Li Xue Bao Section Abstract Doc Link 11499006 Disease Relevance 0.15 Pain Relevance 1.17
Brainstem phosphorylated extracellular signal-regulated kinase 1/2-nitric-oxide synthase signaling mediates the adenosine A2A-dependent hypotensive action of clonidine in conscious aortic barodenervated rats.
Phosphorylation (phosphorylated) of nitric-oxide synthase in Brainstem associated with medulla, adenocard, hypotension and clonidine
2) Confidence 0.20 Published 2008 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 17934014 Disease Relevance 0.44 Pain Relevance 0.80
Immunophilin ligands, cyclosporine A and FK506 (tacrolimus), besides their immunosuppressive action, have several effects on different neural functions, such as modulation of the release of many neurotransmitters, the reduction of nitric oxide (NO) production by the inhibition of dephosphorylation of neuronal nitric oxide synthase (nNOS) and the alteration of the expression of certain genes.
Phosphorylation (dephosphorylation) of nNOS in neuronal associated with neurotransmitter and neuronal nitric oxide synthase
3) Confidence 0.15 Published 2003 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12706476 Disease Relevance 0 Pain Relevance 0.62

General Comments

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