INT9753

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Context Info
Confidence 0.49
First Reported 1989
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 8
Total Number 8
Disease Relevance 1.72
Pain Relevance 6.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Crhr1) response to stress (Crhr1) signal transducer activity (Crhr1)
Anatomy Link Frequency
neuron 2
hindlimbs 2
Crhr1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cocaine 24 99.98 Very High Very High Very High
lidocaine 21 99.98 Very High Very High Very High
tetrodotoxin 15 99.70 Very High Very High Very High
gABA 6 99.28 Very High Very High Very High
sodium channel 6 99.18 Very High Very High Very High
dexamethasone 6 97.56 Very High Very High Very High
Calcium channel 6 96.44 Very High Very High Very High
Migraine 10 94.72 High High
carbamazepine 3 93.68 High High
Neurotransmitter 9 92.16 High High
Disease Link Frequency Relevance Heat
Stress 7 99.36 Very High Very High Very High
Headache 10 94.72 High High
Convulsion 6 77.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These interactions may result from biochemical changes related to the physiological stress response, as, for example, the release of corticotrophin releasing hormone, or from changes induced by the psychological response to stressors.
Positive_regulation (induced) of Localization (release) of corticotrophin releasing hormone associated with stress
1) Confidence 0.49 Published 2009 Journal Headache Section Abstract Doc Link 19619238 Disease Relevance 1.29 Pain Relevance 0.72
Pinching of the bilateral forepaws or hindpaws and brushing of the bilateral hindlimbs for 20 min increased hypothalamic iCRH secretion.
Positive_regulation (increased) of Localization (secretion) of iCRH in hindlimbs
2) Confidence 0.45 Published 1992 Journal Jpn. J. Physiol. Section Abstract Doc Link 1434108 Disease Relevance 0 Pain Relevance 0.13
On the other hand, cocaine-induced iCRH secretion was inhibited by GABA, a potent inhibitor of CRH secretion, dexamethasone, verapamil, a calcium channel blocker, tetrodotoxin, a sodium channel blocker, and carbamazepine, an antiepileptic and antidepressive agent.
Positive_regulation (induced) of Localization (secretion) of iCRH associated with tetrodotoxin, gaba, calcium channel, sodium channel, dexamethasone, carbamazepine and cocaine
3) Confidence 0.20 Published 1989 Journal Brain Res. Section Abstract Doc Link 2611679 Disease Relevance 0 Pain Relevance 0.80
Isolated or simultaneous pharmacologic blockade of cholinergic (atropine plus hexamethonium), serotonergic (ritanserin), alpha-adrenergic (phentolamine) and/or dopaminergic (compound SCH 23390) receptor subtypes failed to inhibit cocaine-induced iCRH secretion.
Positive_regulation (induced) of Localization (secretion) of iCRH associated with cocaine
4) Confidence 0.20 Published 1989 Journal Brain Res. Section Abstract Doc Link 2611679 Disease Relevance 0 Pain Relevance 0.80
Cocaine stimulated iCRH secretion in a dose-dependent fashion with peak of activity at 10(-8) M.
Positive_regulation (stimulated) of Localization (secretion) of iCRH associated with cocaine
5) Confidence 0.13 Published 1989 Journal Brain Res. Section Abstract Doc Link 2611679 Disease Relevance 0 Pain Relevance 0.79
Moreover, TTX inhibited lidocaine-induced iCRH secretion but had no influence on the response of the CRH neuron to procaine.
Positive_regulation (induced) of Localization (secretion) of iCRH in neuron associated with tetrodotoxin and lidocaine
6) Confidence 0.13 Published 1990 Journal Horm. Metab. Res. Section Abstract Doc Link 1968416 Disease Relevance 0.14 Pain Relevance 1.14
To accomplish this, we first explored the effect of the sodium channel blocker tetrodotoxin (TTX) on basal and stimulated immunoreactive CRH (iCRH) secretion by explanted rat hypothalami.
Positive_regulation (stimulated) of Localization (secretion) of iCRH associated with tetrodotoxin and sodium channel
7) Confidence 0.09 Published 1990 Journal Horm. Metab. Res. Section Abstract Doc Link 1968416 Disease Relevance 0.15 Pain Relevance 1.08
In contrast to procaine and lidocaine, TTX inhibited rather than stimulated iCRH secretion.
Positive_regulation (stimulated) of Localization (secretion) of iCRH associated with tetrodotoxin and lidocaine
8) Confidence 0.09 Published 1990 Journal Horm. Metab. Res. Section Abstract Doc Link 1968416 Disease Relevance 0.14 Pain Relevance 1.10

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