INT97560

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Context Info
Confidence 0.44
First Reported 2000
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 2.71
Pain Relevance 1.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Fos) nucleolus (Fos) nucleus (Fos)
DNA binding (Fos) transcription factor binding (Fos) response to stress (Fos)
Anatomy Link Frequency
spinal 2
brain 2
striatum 2
thalamus 2
barrel cortex 2
Fos (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Hippocampus 26 100.00 Very High Very High Very High
addiction 3 100.00 Very High Very High Very High
Thalamus 2 100.00 Very High Very High Very High
allodynia 1 97.16 Very High Very High Very High
Inflammation 4 96.76 Very High Very High Very High
Antinociceptive 1 93.68 High High
Pain 9 90.40 High High
narcan 1 89.32 High High
antagonist 3 88.96 High High
opioid receptor 2 88.52 High High
Disease Link Frequency Relevance Heat
Stress 112 98.20 Very High Very High Very High
Neuropathic Pain 1 97.16 Very High Very High Very High
INFLAMMATION 2 96.76 Very High Very High Very High
Pain 5 90.40 High High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

10 83.84 Quite High
Colitis 5 83.28 Quite High
Nociception 3 82.72 Quite High
Dyspepsia 1 53.04 Quite High
Functional Bowel Disorder 1 48.80 Quite Low
Hypersensitivity 16 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this setting,NO2-Arg-Trim but not trimebutine, significantly down-regulated the spinal cFOS mRNA expression and increased blood concentrations of NO2 +NO3.
Neg (not) Regulation (regulated) of Transcription (expression) of cFOS in spinal
1) Confidence 0.44 Published 2009 Journal Pharmacol. Res. Section Abstract Doc Link 19416632 Disease Relevance 1.16 Pain Relevance 1.10
To further probe the dose-dependence of c-Fos and Egr-1 transcription on propofol concentration, we exposed the hippocampal slices to increasing concentrations of propofol for 60 min.
Regulation (dependence) of Transcription (transcription) of c-Fos associated with addiction
2) Confidence 0.44 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2916009 Disease Relevance 0 Pain Relevance 0.05
Pretreatment of hippocampal slices with RAS, RAF, MEK, ERK or p38-MAPK inhibitors for 60 min did not significantly change the transcription of c-Fos or Egr-1.
Neg (not) Regulation (change) of Transcription (transcription) of c-Fos
3) Confidence 0.44 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2916009 Disease Relevance 0 Pain Relevance 0
AIM: To study that l-stepholidine (SPD) regulates the expression of proenkephalin (PENK) and prodynorphin (PDYN) mRNA and Fos in the striatum after rotational test in the 6-hydroxydopamine (6-OHDA)-lesioned rats.
Regulation (regulates) of Transcription (expression) of Fos in striatum
4) Confidence 0.43 Published 2000 Journal Acta Pharmacol. Sin. Section Abstract Doc Link 11501038 Disease Relevance 0 Pain Relevance 0
The purpose of this study was to evaluate the effects of propofol stimulation on c-Fos and Egr-1 gene transcription in hippocampal brain slices at varying doses and time intervals.
Regulation (effects) of Transcription (transcription) of c-Fos in brain
5) Confidence 0.26 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2916009 Disease Relevance 0 Pain Relevance 0
Higher basal c-fos mRNA expression at D16 was also seen in other subfields of the hippocampus, in the dorsal endopiriform cortex, and in various divisions of the thalamus (anterodorsal, anteroventral and paraventricular nuclei) (Figs. 1 Ci; 2Ai; Bi), although in these areas variance in the expression levels meant that the difference between groups did not reach statistical significance (e.g.
Regulation (meant) of Transcription (expression) of fos in thalamus associated with thalamus and hippocampus
6) Confidence 0.22 Published 2010 Journal Brain Research Section Body Doc Link PMC2994639 Disease Relevance 0.28 Pain Relevance 0.23
However, a markedly different pattern of c-fos mRNA expression was observed in other brain areas, including barrel cortex and CA1 ventral and CA3 regions of the ventral hippocampus: D19 animals had low control expression which was increased by restraint, but D16 control animals had raised c-fos mRNA expression which was not further elevated by stress.
Regulation (control) of Transcription (expression) of fos in barrel cortex associated with stress and hippocampus
7) Confidence 0.22 Published 2010 Journal Brain Research Section Abstract Doc Link PMC2994639 Disease Relevance 0.65 Pain Relevance 0.09

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