INT97571

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.43
First Reported 2001
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 13
Total Number 15
Disease Relevance 1.61
Pain Relevance 1.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (PRKCA) mitochondrion (PRKCA) small molecule metabolic process (PRKCA)
endoplasmic reticulum (PRKCA) enzyme binding (PRKCA) cytoplasm (PRKCA)
Anatomy Link Frequency
tail 4
neurons 2
PRKCA (Homo sapiens)
Pain Link Frequency Relevance Heat
Kinase C 102 100.00 Very High Very High Very High
agonist 351 98.76 Very High Very High Very High
adenocard 37 97.56 Very High Very High Very High
lidocaine 1 89.08 High High
imagery 11 88.96 High High
Dopamine 16 83.00 Quite High
Neurotransmitter 14 77.72 Quite High
Calcium channel 14 75.36 Quite High
b2 receptor 3 66.96 Quite High
bradykinin 9 60.56 Quite High
Disease Link Frequency Relevance Heat
Glioma 4 99.96 Very High Very High Very High
Hyperglycemia 38 99.30 Very High Very High Very High
Stress 65 97.60 Very High Very High Very High
Necrosis 19 86.08 High High
Diabetes Mellitus 85 85.44 High High
Carcinoma 1 79.24 Quite High
Acute Liver Failure 1 77.96 Quite High
Injury 23 75.76 Quite High
Apoptosis 130 74.80 Quite High
Breast Cancer 6 65.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
1-adrenoreceptors) mitoKATP channels are opened via Gi proteins and PKC, possibly PKC-?
Spec (possibly) Positive_regulation (via) of Spec (possibly) Gene_expression (possibly) of PKC associated with kinase c
1) Confidence 0.43 Published 2002 Journal BMC Physiol Section Body Doc Link PMC117790 Disease Relevance 0 Pain Relevance 0.32
1-adrenoreceptors) mitoKATP channels are opened via Gi proteins and PKC, possibly PKC-?
Spec (possibly) Positive_regulation (via) of Spec (possibly) Gene_expression (possibly) of PKC associated with kinase c
2) Confidence 0.43 Published 2002 Journal BMC Physiol Section Body Doc Link PMC117790 Disease Relevance 0 Pain Relevance 0.32
We hypothesized that increased prostaglandin production by Cox-2 induces PKC and the expression of transcriptional factor c-Jun, which in turn, induces the expression of MDR1/Pgp170.
Positive_regulation (induces) of Gene_expression (expression) of PKC
3) Confidence 0.23 Published 2001 Journal Anticancer Res. Section Body Doc Link 11501838 Disease Relevance 0.07 Pain Relevance 0
An increased expression of PLC-beta3 and PKC-alpha and -beta2 was also evidentiated at the longer time points explored, when the effects of ATRA in preservation of the differentiated morphology were maximal.
Positive_regulation (increased) of Gene_expression (expression) of PKC-alpha
4) Confidence 0.16 Published 2003 Journal Int J Artif Organs Section Abstract Doc Link 12866655 Disease Relevance 0.08 Pain Relevance 0.09
Whether TXA2-mediated PKC activation contributes to PKG1?
Positive_regulation (mediated) of Gene_expression (activation) of PKC
5) Confidence 0.13 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2680961 Disease Relevance 0 Pain Relevance 0.12
Hence, while Ser145 within the IC2 domain plays a role in the GF 109203X-sensitive, PKC-dependent homologous desensitization of signalling by TP?
Positive_regulation (Hence) of Gene_expression (desensitization) of PKC-dependent
6) Confidence 0.13 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2680961 Disease Relevance 0 Pain Relevance 0.12
receptor (FP), those phosphorylations/desensitizations occur at distinct PKC sites within the unique C-tail domains of TP?
Positive_regulation (occur) of Gene_expression (sites) of PKC in tail
7) Confidence 0.13 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2680961 Disease Relevance 0 Pain Relevance 0.04
NCTC2544-PAR2 cells were found to express the PKC isoforms, PKC?
Positive_regulation (-) of Gene_expression (express) of PKC
8) Confidence 0.11 Published 2010 Journal Cellular Signalling Section Body Doc Link PMC2806525 Disease Relevance 0 Pain Relevance 0.06
NCTC2544-PAR2 cells were found to express the PKC isoforms, PKC?
Positive_regulation (-) of Gene_expression (isoforms) of PKC
9) Confidence 0.11 Published 2010 Journal Cellular Signalling Section Body Doc Link PMC2806525 Disease Relevance 0 Pain Relevance 0.06
NCTC2544-PAR2 cells were found to express the PKC isoforms, PKC?
Positive_regulation (NCTC2544) of Gene_expression (express) of PKC
10) Confidence 0.11 Published 2010 Journal Cellular Signalling Section Body Doc Link PMC2806525 Disease Relevance 0 Pain Relevance 0.06
NCTC2544-PAR2 cells were found to express the PKC isoforms, PKC?
Positive_regulation (-) of Gene_expression (express) of PKC
11) Confidence 0.11 Published 2010 Journal Cellular Signalling Section Body Doc Link PMC2806525 Disease Relevance 0 Pain Relevance 0.06
In addition, from our work in the pituitary field, and the work of others, we know that multiple estrogens induce activation of MAPKs.129,130 The estrogenic activation of other kinases likely to act on DATÂ’s N-terminal tail have yet to be investigated;93,131 these include PKA, PKG, the subtypes of PKC (?
Positive_regulation (include) of Gene_expression (subtypes) of PKC in tail
12) Confidence 0.09 Published 2010 Journal International Journal of Women's Health Section Body Doc Link PMC2971739 Disease Relevance 0 Pain Relevance 0.13
Oxidative stress is probably a key event in endothelial dysfunction since inhibition of hyperglycemia, induced, ROS production prevents activation of the aldose reductase, hexosamine pathways, PKC activation, and AGE formation [77, 89].
Positive_regulation (activation) of Gene_expression (activation) of PKC associated with hyperglycemia, stress and kinase c
13) Confidence 0.07 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2903979 Disease Relevance 0.81 Pain Relevance 0.05
is involved in the activation of the PKC, MAPK and AKT pathways in neurons from mES cells, which is consistent with other studies [58], [82], [83].
Positive_regulation (activation) of Gene_expression (pathways) of PKC in neurons associated with kinase c
14) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2910705 Disease Relevance 0 Pain Relevance 0.18
The results suggested that radioiodine labeled hypericin could visualize a PKC overexpressed malignant glioma.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of PKC associated with glioma
15) Confidence 0.04 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2852855 Disease Relevance 0.66 Pain Relevance 0.09

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox