INT97598

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Context Info
Confidence 0.42
First Reported 2001
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 6.52
Pain Relevance 4.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (S100a8) extracellular region (S100a8) plasma membrane (S100a8)
cytoskeleton (S100a8) cytoplasm (S100a8)
Anatomy Link Frequency
macrophages 4
inflammatory macrophage 2
microglia 2
S100a8 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 250 100.00 Very High Very High Very High
cytokine 95 100.00 Very High Very High Very High
Inflammatory mediators 5 100.00 Very High Very High Very High
cINOD 76 99.98 Very High Very High Very High
Central nervous system 33 99.92 Very High Very High Very High
Neuropathic pain 5 97.20 Very High Very High Very High
medulla 19 96.84 Very High Very High Very High
Peripheral nerve injury 1 93.40 High High
Opioid 1 88.88 High High
Inflammatory response 13 87.12 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 273 100.00 Very High Very High Very High
Stress 5 98.64 Very High Very High Very High
Neuropathic Pain 6 97.20 Very High Very High Very High
Gliosis 25 95.92 Very High Very High Very High
Acne 82 95.36 Very High Very High Very High
Nervous System Injury 2 93.40 High High
Motor Neuron Diseases 42 90.88 High High
Disease 72 90.20 High High
Neurodegenerative Disease 133 90.16 High High
Nociception 5 89.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Depletion of S100A8 inhibited S-CorNV and inflammation
Negative_regulation (inhibited) of Localization (Depletion) of S100A8 associated with inflammation
1) Confidence 0.42 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2994359 Disease Relevance 0.49 Pain Relevance 0.13
Concluding, this study clearly shows minocycline, an inhibitor of microglial activation, by inhibiting the release of pro-inflammatory mediators and reducing oxidative stress prevented the development of neuropathic pain.
Negative_regulation (inhibiting) of Localization (release) of pro-inflammatory associated with stress, inflammatory mediators and neuropathic pain
2) Confidence 0.36 Published 2008 Journal Eur. J. Pharmacol. Section Abstract Doc Link 18952075 Disease Relevance 1.71 Pain Relevance 0.80
Chronic administration of melatonin for 5 days to antigen-primed mice increased the production of pro-inflammatory cytokine IL-10 but decreased the secretion of anti-inflammatory cytokine TNF-alpha.
Negative_regulation (decreased) of Localization (secretion) of anti-inflammatory cytokine TNF-alpha associated with inflammation and cytokine
3) Confidence 0.20 Published 2001 Journal Mol. Cell. Biochem. Section Abstract Doc Link 11506187 Disease Relevance 0.20 Pain Relevance 0.47
Experiments carried out in cultured microglia have revealed that incubation with NSAIDs decreased the secretion of pro-inflammatory cytokines and may increase A?
Negative_regulation (decreased) of Localization (secretion) of pro-inflammatory in microglia associated with inflammation, cinod and cytokine
4) Confidence 0.03 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2893374 Disease Relevance 0.68 Pain Relevance 0.83
In order to determine whether BV suppressed neuroinflammation by inhibiting of the release of the pro-inflammatory cytokine TNF-?
Spec (whether) Negative_regulation (inhibiting) of Localization (release) of pro-inflammatory associated with inflammation and cytokine
5) Confidence 0.02 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2974667 Disease Relevance 0.38 Pain Relevance 0.53
Treatment with the selected active fraction Rx caused a drastic reduction in secretion of pro-inflammatory cytokines including MCP-1 and IL-6 in the conditioned medium of THP-1 macrophages, in a dose-dependent manner (figure 3a, b).
Negative_regulation (reduction) of Localization (secretion) of pro-inflammatory in macrophages associated with inflammation and cytokine
6) Confidence 0.02 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2936435 Disease Relevance 0.38 Pain Relevance 0.35
After repeatedly screening, we identified an active fraction (Rx) from Radix Astragali that reproducibly inhibited the pro-inflammatory cytokine secretion from macrophages.
Negative_regulation (inhibited) of Localization (secretion) of pro-inflammatory in macrophages associated with inflammation and cytokine
7) Confidence 0.02 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2936435 Disease Relevance 0.34 Pain Relevance 0.29
Our data demonstrate that activin A exerts potent anti-inflammatory effects in the CNS by suppressing microglial numbers, microglial activation, and pro-inflammatory cytokine release.
Negative_regulation (suppressing) of Localization (release) of pro-inflammatory associated with inflammation, central nervous system and cytokine
8) Confidence 0.01 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2733378 Disease Relevance 1.43 Pain Relevance 0.77
Furthermore, the sialidase-immunized mice provided protective immunity against P. acnes in vivo as this treatment blocked an increase in ear thickness and release of pro-inflammatory macrophage inflammatory protein (MIP-2) cytokine.


Negative_regulation (blocked) of Localization (release) of pro-inflammatory in inflammatory macrophage associated with inflammation and cytokine
9) Confidence 0.00 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2212713 Disease Relevance 0.92 Pain Relevance 0.15

General Comments

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