INT97599

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Context Info
Confidence 0.23
First Reported 2001
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 5.11
Pain Relevance 2.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il20) extracellular region (Il20)
Anatomy Link Frequency
fibroblasts 1
keratinocyte 1
T-cell 1
Il20 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 140 100.00 Very High Very High Very High
Inflammation 121 100.00 Very High Very High Very High
chemokine 42 100.00 Very High Very High Very High
rheumatoid arthritis 228 96.64 Very High Very High Very High
Arthritis 57 96.00 Very High Very High Very High
psoriasis 88 94.36 High High
isoflurane 10 91.68 High High
Osteoarthritis 11 87.92 High High
Opioid 1 83.44 Quite High
antagonist 14 75.00 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 124 100.00 Very High Very High Very High
Targeted Disruption 8 98.92 Very High Very High Very High
Apoptosis 53 98.64 Very High Very High Very High
Rheumatoid Arthritis 230 96.64 Very High Very High Very High
Arthritis 36 96.00 Very High Very High Very High
Necrosis 13 96.00 Very High Very High Very High
Cancer 18 95.64 Very High Very High Very High
Psoriasis 98 94.36 High High
Acanthosis 8 93.16 High High
Adhesions 13 92.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Chronic administration of melatonin for 5 days to antigen-primed mice increased the production of pro-inflammatory cytokine IL-10 but decreased the secretion of anti-inflammatory cytokine TNF-alpha.
Gene_expression (production) of cytokine IL-10 associated with inflammation and cytokine
1) Confidence 0.23 Published 2001 Journal Mol. Cell. Biochem. Section Abstract Doc Link 11506187 Disease Relevance 0.20 Pain Relevance 0.45
We also measured the plasma levels of the pro-inflammatory cytokines TNF-alpha, keratinocyte-derived chemokine (KC), and IL-6 and an anti-inflammatory cytokine IL-10.
Gene_expression (levels) of cytokine IL-10 in keratinocyte associated with chemokine, inflammation and cytokine
2) Confidence 0.15 Published 2007 Journal Shock Section Abstract Doc Link 17414419 Disease Relevance 1.60 Pain Relevance 0.86
In this study, splenocytes from DO11.10 T-cell antigen receptor (TCR) transgenic mice activated with ovalbumin peptide preferentially produced IL-22, but not the related cytokines, IL-19, IL-20 or IL-24, after IL-23 stimulation.
Neg (not) Gene_expression (produced) of IL-20 in T-cell associated with targeted disruption and cytokine
3) Confidence 0.12 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2768824 Disease Relevance 1.19 Pain Relevance 0.41
IL-20 and its receptors were expressed in synovial membranes and synovial fibroblasts derived from the synovial tissue of RA patients and CIA rats, as demonstrated by immunohistochemistry [38].
Gene_expression (expressed) of IL-20 in fibroblasts associated with rheumatoid arthritis and arthritis
4) Confidence 0.12 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2768824 Disease Relevance 1.63 Pain Relevance 0.80
Both IL-17 and IL-18 increased the synthesis of the proangiogenic factor VEGF, and IL-20 promoted enhanced chemotaxis via MCP-1 and IL-8 [33-35].
Gene_expression (synthesis) of IL-20
5) Confidence 0.03 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246247 Disease Relevance 0.49 Pain Relevance 0.46

General Comments

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